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CASP4 — INS

Text-mined interactions from Literome

Godbout et al., Cell Signal 1999 : Insulin activates caspase-3 by a phosphatidylinositol 3'-kinase dependent pathway ... Caspase assays demonstrated that insulin increased caspase-3 activity 3-fold and that inhibition of PI3-kinase blocked this effect ... Taken together, these findings indicate that insulin activates caspase-3 by a PI3-kinase dependent pathway resulting in increased apoptosis and cell death
Hermann et al., Arterioscler Thromb Vasc Biol 2000 : In contrast, insulin inhibited caspase-9 activity and prevented caspase-9 induced apoptosis
Ido et al., Diabetes 2002 (Hyperglycemia) : The results indicate that alterations in fatty-acid metabolism, impaired Akt activation by insulin , and increased caspase-3 activity precede visible evidence of apoptosis in HUVEC incubated in a hyperglycemic medium
Bhat et al., J Alzheimers Dis 2002 : To determine whether these pathways interact from a signalling perspective, we compared the effects of BAF ( a general caspase inhibitor ), Li+ ( a GSK3beta inhibitor ) and insulin on NGF-W induced PC12 cell death
Lo et al., J Orthop Res 2004 : Collagenase was added to the cells in the presence and absence of caspase inhibitors and insulin like growth factor (IGF)-1
Valverde et al., Hepatology 2004 : Infection of IRS-2 ( -/- ) hepatocytes with adenovirus encoding IRS-2 reconstituted phosphatidylinositol 3-kinase ( PI 3-kinase ) /Akt/Foxo1 signaling, restored pro- and antiapoptotic gene expression, and decreased caspase-3 activity in response to insulin , thereby blocking apoptosis
Hui et al., Brain Res 2005 (Brain Ischemia) : In contrast, insulin , a PI3K agonist, not only obviously activated Akt1 during early and later reperfusion, but also inhibited phosphorylation of JNK1/2, c-Jun, and Bcl-2 and attenuated the activation of caspase-3
Pagliassotti et al., Endocrinology 2007 : Insulin reduced palmitate mediated activation of caspase-3 and DNA fragmentation in a dose dependent manner
Yen et al., Toxicol Lett 2007 (Diabetes Mellitus) : Treatment of HIT-T15 cells with HA, As, or both of them resulted loss of cell viability, apoptosis, depletion of ATP, increment of oxidative stress, activation of caspase 3, and dysfunction of insulin secretion
Zhao et al., Neurosci Lett 2007 (Anoxia) : In addition, we showed that insulin reduced the activation of caspase-3 , the key executor of apoptosis
Liu et al., J Am Soc Nephrol 2008 (Albuminuria...) : In vitro, high-glucose medium significantly increased apoptosis and caspase-3 activity in rat immortalized RPTC overexpressing angiotensinogen compared with control cells, and these changes were prevented by insulin and/or RAS blockers
Meier et al., Cell Physiol Biochem 2008 : Insulin inhibits caspase-3 activity in human renal tubular epithelial cells via the PI3-kinase/Akt pathway
Jafari Anarkooli et al., Cell Mol Neurobiol 2009 (Body Weight...) : Effects of insulin and ascorbic acid on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study
Gao et al., J Appl Physiol 2008 : Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2 ... In the present experiments, we examined how insulin regulates caspase-3 activity in L6 myotubes ... Addition of insulin to proteolytically active cells attenuated both responses within 4 h. Individually, inhibitors of either phosphatidylinositide 3-kinase (PI3K) or MEK1/2 partially blocked the insulin induced reduction in caspase-3 activity ; in combination, the inhibitors completely prevented insulin from attenuating caspase-3 activity ... Insulin suppressed caspase-3 activity by a complex mechanism that included direct inhibition due to an increased interaction between caspase-3 and cellular inhibitor of apoptosis-1 and indirect inhibition via phosphorylation ( i.e., inactivation ) of the proapoptotic protein Bad, which participates in the intrinsic ( i.e., mitochondrial ) apoptosis activation cascade ... In summary, our findings indicate that insulin regulates caspase-3 activity by a multistep process that is unique to skeletal muscle, thus providing insights about the muscle-specific nature of the atrophy process
Kaifu et al., Nephrol Dial Transplant 2009 : Insulin attenuated caspase 3 activity and decreased the number of TUNNEL positive cells
Lee et al., Cancer Res 2009 (Ovarian Neoplasms) : Resveratrol also activated caspase-9 , -7, and -3 and induced apoptosis in PA-1 cells in the presence of insulin or serum
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons ... Insulin and insulin-like growth factor-1 and their combination inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1ß treatment
Theil et al., Meat Sci 2006 : The temporal changes in transcription of micro molar-, milli molar- and muscle specific calpains ( p94 ), calpastatin and caspase 3 in response to insulin was evaluated and myogenin transcription and creatine kinase activity was determined to indicate differentiation
Cai et al., Diabetes 2012 (Glucose Intolerance...) : Reduced ß-cell viability and proliferation resulting in decreased ß-cell mass was observed in these mice, which was associated with attenuated insulin/Akt ( also known as protein kinase B ) and extracellular signal related kinase 1/2 signaling and increased caspase 3 activation