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CASP4 — CFL1
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Mazumder et al., Mol Cell Biol 2002
:
The
p18-cyclin E expression was
prevented by Bcl-2 overexpression and by the general
caspase and specific caspase 3 pharmacologic inhibitors zVAD-fluoromethyl ketone ( zVAD-fmk ) and N-acetyl-Asp-Glu-Val-Asp-aldehyde ( DEVD-CHO ), indicating that it was linked to apoptosis
Hsieh et al., Chem Res Toxicol 2010
(Liver Neoplasms) :
Additionally, pretreatment of Huh7 cells with antioxidants ascorbic acid and N-acetyl cysteine markedly attenuated the MAA induced apoptosis by upregulation of Bax, Bak, and PUMA, mitochondrial translocation of
cofilin ,
activation of
caspase-3 , and cell death