Baruah et al., J Leukoc Biol 2006
:
C1q increases the phagocytosis of apoptotic cells by DC and the release of interleukin-12 in the presence of TLR4 ligands and apoptotic cells ; PTX3 inhibits both events
Bottazzi et al., J Biol Chem 1997
:
The capacity to bind C1q , mediated by the pentraxin domain, is consistent with the view that PTX3, produced in tissues by endothelial cells or macrophages in response to interleukin-1 and tumor necrosis factor, may act as a local regulator of innate immunity