UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PSMA1

PSMA1 — PSMD14

Pathways - manually collected, often from reviews:

BioCarta proteasome complex: 26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7) → None (degradation, activates)
BioCarta proteasome complex: 26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7) (degradation, activates)
BioCarta proteasome complex: PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1) → 26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7) (modification, collaborate)
BioCarta proteasome complex: PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1) → 20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2) (modification, collaborate)
BioCarta proteasome complex: 26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7) → 20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2) (modification, collaborate)
BioCarta proteasome complex: PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1) → 20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2) (modification, collaborate)
BioCarta proteasome complex: PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1) → Hybrid Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMD3-PSMD12-PSMD11-PSMA2-PSMD14-RPN1-RPN2-PSMD4-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2) (modification, collaborate)
BioCarta proteasome complex: 20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2) → Hybrid Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMD3-PSMD12-PSMD11-PSMA2-PSMD14-RPN1-RPN2-PSMD4-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2) (modification, collaborate)
Reactome Reaction: PSMD14 → PSMA1 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: PSMD14 — PSMA1 (colocalization, biochemical) Havugimana et al., Cell 2012
IRef Biogrid Interaction: PSMD14 — PSMA1 (physical association, affinity chromatography technology) Isakov et al., J Biol Chem 2011 *
MIPS CORUM PA700-20S-PA28 complex: PA700-20S-PA28 complex complex (PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMC1-PSMC2-PSMC3-PSMC4-PSMC5-PSMC6-PSMD1-PSMD10-PSMD11-PSMD12-PSMD13-PSMD14-PSMD2-PSMD3-PSMD4-PSMD5-PSMD6-PSMD7-PSMD8-PSMD9-PSME1-PSME2) Kopp et al., J Mol Biol 2001
IRef Corum Interaction: Complex of 37 proteins (association, cosedimentation through density gradient) Kopp et al., J Mol Biol 2001
Gene Ontology Complexes proteasome complex: proteasome complex complex (PSMB11-PSME4-SLC10A2-UBQLN1-PSMA1-PSMA6-PSMA5-PSMC1-PSMC4-UBXN1-HSPB1-TXNL1-PSME2-USP14-PSMD14-PSMD11-PSMD13-PSMD12-PSMB7-PSMB5-PSMB4-PSMB2-PSMB1) McNeill et al., Biochem J 2004, Wang et al., Biochemistry 2007, Cooper et al., EMBO J 2009, Choi et al., J Steroid Biochem Mol Biol 1996, Coux et al., Annu Rev Biochem 1996, Hoffman et al., FEBS Lett 1997, Spataro et al., J Biol Chem 1997
IRef Intact Interaction: Complex of 46 proteins (association, anti tag coimmunoprecipitation) Yao et al., Mol Cell 2008
IRef Intact Interaction: Complex of 34 proteins (association, anti tag coimmunoprecipitation) Yao et al., Mol Cell 2008
IRef Intact Interaction: Complex of 33 proteins (association, anti tag coimmunoprecipitation) Kaneko et al., Cell 2009
IRef Ophid Interaction: PSMD14 — PSMA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Husom et al., Arch Biochem Biophys 2004 (Atrophy) : These results suggest significant alterations in the intrinsic activity, the percentage of immunoproteasome, and the regulation of the 20S proteasome by PA28 and PA700 in aged muscle
Thompson et al., J Biol Chem 2009 : Subcomplexes of PA700 , the 19 S regulator of the 26 S proteasome , reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activity