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EPHB2 — SST
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Sellers et al., J Biol Chem 1999
:
Mitogen activated protein/ERK kinase-1 inhibition also decreased the time interval over which
somatostatin induced ERK phosphorylation was observed ( < 2 h )
Sellers et al., J Biol Chem 1999
:
In contrast, the
somatostatin induced phosphorylation of
ERK obtained at 4 h, although sensitive to both pertussis toxin and transducin, was unaffected by PP1 but ablated by PD 98059 ... Protein kinase C inhibition also abolished this
somatostatin induced sustained phosphorylation of
ERK , together with the associated increase in cell proliferation ... Expression of dominant negative Ras ( N17 ) failed to significantly reduce the proliferative effect mediated by the sst ( 4 ) receptor but markedly attenuated the acute phase of the
somatostatin induced phosphorylation of
ERK obtained at 10 min
Florio et al., J Physiol Paris 2000
(MAP Kinase Signaling System) :
However, in these cells,
somatostatin robustly activates the MAP kinase and
augments bFGF induced stimulation of
ERK
Barbieri et al., Am J Physiol Endocrinol Metab 2009
(Brain Neoplasms...) :
Somatostatin and SSTR1, -2, and -5 agonists strongly
inhibited in vivo C6 tumor growth, intratumoral neovessel formation, Ki-67 expression, and
ERK1/2 phosphorylation and induced upregulation of p27 ( Kip1 ), whereas only a modest activation of caspase-3 was observed
Cescato et al., Mol Endocrinol 2010
(Calcium Signaling) :
In sst2A expressing HEK293 cells,
somatostatin inhibited cAMP production, stimulated intracellular calcium accumulation, and
increased ERK phosphorylation ... However, although
somatostatin increased intracellular calcium and
ERK phosphorylation, SOM230 and KE108 again antagonized these effects ... Our results demonstrate that SOM230 and KE108 behave as agonists for inhibition of adenylyl cyclase but antagonize
somatostatin 's
actions on intracellular calcium and
ERK phosphorylation
Peverelli et al., J Cell Sci 2013
(Growth Hormone-Secreting Pituitary Adenoma) :
Moreover, we demonstrated that silencing of GaoA completely abolished
SST5 mediated inhibitory
effects on GH secretion and
ERK1/2 phosphorylation, but not on cAMP levels
Todisco et al., Am J Physiol 1997
:
Because the extracellular signal regulated protein kinases ( ERKs ) induce the SRE via phosphorylation of transcription factors such as Elk-1, we examined the
effect of
somatostatin on
ERK phosphorylation and activation
Florio et al., Mol Endocrinol 1999
:
However, in these cells,
somatostatin robustly activates MAP kinase ( also called extracellular signal regulated kinase ; ERK ) and
augments fibroblast growth factor stimulated
ERK activity