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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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MAPK10 — TIMP2

Text-mined interactions from Literome

Ihn et al., J Immunol 2002 (MAP Kinase Signaling System) : The expression of the dominant negative mutant p38 MAPK represses the IL-4 induced TIMP-2 expression in human dermal fibroblasts
Munshi et al., J Biol Chem 2004 (Carcinoma, Squamous Cell...) : The cellular mechanism for the control of MT1-MMP catalytic activity involved concurrent reciprocal modulation of TIMP-2 expression by ERK1/2 and p38 MAPKs, such that inhibition of ERK1/2 phosphorylation decreased TIMP-2 production, and down-regulation of p38 MAPK activity enhanced TIMP-2 synthesis
D'Alessio et al., J Biol Chem 2008 : Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism
Seo et al., Microvasc Res 2008 (MAP Kinase Signaling System) : We also show that TIMP-2 inhibition of FGF-2 induced p42/44(MAPK) activation and cell proliferation is associated with TIMP-2 binding to integrin alpha3beta1 on endothelial cell surfaces, as demonstrated by use of anti-integrin alpha3 or beta1 blocking antibodies, or disruption of integrin alpha3 expression by siRNA