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FOSL2 — MAPK10
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chen et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
PTHrP mediated down-regulation of PTH-1R mRNA and up-regulation of c-fos mRNA were MAPK independent, whereas PTHrP stimulation of
fra-2 and interleukin-6 (IL-6) mRNA was
MAPK dependent
Cook et al., Mol Cell Biol 1999
:
In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of
Raf-MEK-MAPK was
sufficient to induce expression of Fra-1,
Fra-2 , and JunB but, interestingly, induced little or no c-Fos or c-Jun ... These results suggest that kinetically distinct phases of MAPK activation serve to regulate the expression of distinct AP-1 components such that sustained
MAPK activation is
required for the induced expression of Fra-1,
Fra-2 , c-Jun, and JunB