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ERBB3 — MAPK10
Text-mined interactions from Literome
Deb et al., J Biol Chem 2001
:
K721M alone exhibited no detectable signaling capacity, whereas coexpression of K721M with ErbB2, but not
ErbB3 or ErbB4,
resulted in EGF dependent
mitogen activated protein kinase ( MAPK ) activation
Vijapurkar et al., Exp Cell Res 2003
(Cell Transformation, Neoplastic...) :
Roles of
mitogen activated protein kinase and phosphoinositide 3'-kinase in
ErbB2/ErbB3 coreceptor mediated heregulin signaling
Arnoletti et al., J Gastrointest Surg 2004
(Adenocarcinoma...) :
Persistent
MAPK activation and impaired in vitro internalization of EGFR by BxPC-3 pancreatic cancer cells may be
due to constitutive
ErbB3 signaling, facilitated by heterodimerization with EGFR, which may explain resistance to Erbitux based combination therapy in vivo
Benlimame et al., J Cell Biol 2005
(Cell Transformation, Neoplastic...) :
ErbB induced oncogenic transformation correlates with the ability of FAK to restore
ErbB-2/3 induced
mitogen activated protein kinase ( MAPK ) activation ; the inhibition of MAPK prevented oncogenic transformation
Balko et al., Proc Natl Acad Sci U S A 2012
(MAP Kinase Signaling System) :
We report here that
ErbB3 loss in the luminal mammary epithelium of mice
impaired Akt and
MAPK signaling and reduced luminal cell proliferation and survival