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ELK1 — MAPK10
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Majka et al., Eur J Haematol 2000
(Leukemia-Lymphoma, Adult T-Cell) :
Activation of
MAPK further
led to the phosphorylation of the nuclear transcription factor
ELK-1
Duan et al., J Biol Chem 2001
:
Estrogen receptor mediated activation of the serum response element in MCF-7 cells through
MAPK dependent phosphorylation of
Elk-1
Woo et al., J Clin Endocrinol Metab 2001
:
In summary, our studies demonstrate, for the first time, that melatonin can regulate progesterone production, LH receptor, GnRH, and GnRH receptor gene expression through melatonin receptors in human granulosa-luteal cells, which may be mediated via the
MAPK pathway and
activation of
Elk-1
Stevens et al., Science 2002
(MAP Kinase Signaling System) :
Knock-out of Sur2 prevents activation by E1A-CR3 and the
mitogen activated protein kinase regulated ETS transcription factor
Elk-1 , but not by multiple other transcription factors
Bea et al., Circ Res 2003
(MAP Kinase Signaling System) :
Furthermore, C pneumoniae stimulated phosphorylation of ERK1/2 and
Elk-1 and pharmacological inhibition of
mitogen activated protein kinase activity
reduced the expression of TF and Egr-1
Chen et al., J Cell Biochem 2004
:
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by
mitogen activated protein kinase dependent phosphorylation of
ELK-1
Vlotides et al., Mol Endocrinol 2006
(Pituitary Neoplasms) :
EGF induced EGFR and ERK1/2 phosphorylation was followed by rapid
MAPK kinase/ERK kinase dependent
activation of
Elk-1 and c-Fos
Muddasani et al., J Biol Chem 2007
:
Taken together, our results suggest that elevated expression of MMP-13 occurs through
Elk-1 activation of both
MAPK and NFkappaB signaling pathways, thus revealing a two pronged biological mechanism by which bFGF controls the production of catabolic enzymes that are associated with excessive degradation of the cartilage matrix in degenerative joint diseases such as osteoarthritis
Wang et al., Neurotox Res 2010
:
Here, we reported that oxLDL induced MMP-9 expression via a PKC-delta/p42/p44
MAPK dependent
Elk-1 activation in rat brain astrocyte ( RBA ) -1 cells, revealed by gelatin zymography, RT-PCR, and Western blotting analyses