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CD40LG — MAPK10

Pathways - manually collected, often from reviews:

• NCI Pathway Database CD40/CD40L signaling: JNK family (MAPK8/MAPK9/MAPK10) → CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2) (modification, collaborate)
  Pullen et al., J Biol Chem 1999, Davies et al., Mol Cell Biol 2005, Rowland et al., J Immunol 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CD40/CD40L signaling: JNK family-active (MAPK8/MAPK9/MAPK10) → CD40/CD40L (trimer)/TRAF3 (trimer) complex (CD40LG-CD40-TRAF3) (modification, collaborate)
  Xie et al., J Exp Med 2004
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Chakrabarti et al., J Biol Chem 2007 (Inflammation) : These data support a mechanism whereby redox-sensitive CD40-CD40L interactions induce activation of Akt and p38 MAPK , leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1
Zhao et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy...) : CD40L induced the phosphorylation of p38 MAPK , extracellular regulated kinase1/2 ( ERK1/2 ), c-Jun NH2-terminal kinase (JNK), and IkappaB and the activation of NF-kappaB
Jiang et al., Circ Res 1996 : Thrombin and TRAP also activate mitogen activated protein kinase ( MAPK ) in cultured neonatal rat ventricular myocytes ... Pretreatment with phorbol 12-myristate 13-acetate ( PMA ) to downregulate protein kinase C ( PKC ) attenuates thrombin- and TRAP dependent activation of MAPK , although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA pretreated cells