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ILK — SLC22A3

Text-mined interactions from Literome

Li et al., J Am Soc Nephrol 2007 (Fibrosis...) : Treatment with an ILK inhibitor or disruption of the ILK/PINCH-1 interaction by overexpressing a dominant negative N-terminal ankyrin domain of ILK resulted in reduced fibronectin deposition, indicating that the ability of PINCH-1 to stimulate EMT is ILK dependent
Liu et al., Am J Nephrol 2008 (Nephritis, Interstitial) : In this study, we investigated the role of integrin linked kinase (ILK) in mediating CTGF induced EMT ... Our study suggested that ILK mediated the effect of EMT in proximal tubular epithelial cells stimulated by CTGF
Li et al., J Am Soc Nephrol 2009 (Disease Models, Animal...) : These findings suggest that increased ILK activity mediates EMT and the progression of renal fibrosis
Kavvadas et al., Virchows Arch 2010 (Disease Models, Animal...) : The in vitro experiments suggested that ILK is not directly involved in E-cadherin downregulation and initiation of EMT ( as is the case in renal fibrosis ) but is involved in upregulation of vimentin
Serrano et al., Oncogene 2013 (Breast Neoplasms) : Role of the integrin linked kinase (ILK)/Rictor complex in TGFß-1 induced epithelial-mesenchymal transition (EMT)
Chen et al., Acta Histochem 2013 (Carcinoma, Non-Small-Cell Lung...) : In addition, the down-regulation of E-cadherin induced by ILK was significantly reversed by nuclear factor-?B ( NF-?B ) inhibitor BAY 11-7028 and small interfering RNA ( siRNA ) targeting NF-?B p65, suggesting a role of the NF-?B signaling pathway in ILK induced EMT
Peng et al., Biol Pharm Bull 2012 : Meanwhile, rhein inhibited the overexpressing ILK and inhibits high glucose induced EMT ; the effect was similar to that of ILK-siRNA
Xing et al., Exp Cell Res 2013 (Carcinoma, Squamous Cell...) : Accumulating evidences suggest that ILK are involved in cell-matrix interactions, cell proliferation, invasion, migration, angiogenesis and Epithelial-mesenchymal transition (EMT)