UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to BRCA1

BRCA1 — TOPBP1

Pathways - manually collected, often from reviews:

NCI Pathway Database BARD1 signaling events: TopBP1 (TOPBP1) → BRCA1/BACH1/BARD1/TopBP1 complex (BRCA1-BARD1-TOPBP1) (modification, collaborate)
Greenberg et al., Genes Dev 2006
Evidence: assay, physical interaction
NCI Pathway Database BARD1 signaling events: TopBP1 (TOPBP1) → BRCA1/BACH1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
Greenberg et al., Genes Dev 2006
Evidence: assay, physical interaction
NCI Pathway Database BARD1 signaling events: BRCA1/BACH1/BARD1/TopBP1 complex (BRCA1-BARD1-TOPBP1) → BRCA1/BACH1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
Greenberg et al., Genes Dev 2006
Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: TOPBP1 — BRCA1 (colocalization, imaging technique) Mok et al., Cell Signal 2010 *
IRef Biogrid Interaction: TOPBP1 — BRCA1 (physical association, affinity chromatography technology) Tian et al., Proc Natl Acad Sci U S A 2013 *
IRef Biogrid Interaction: TOPBP1 — BRCA1 (physical association, affinity chromatography technology) Greenberg et al., Genes Dev 2006
MIPS CORUM BRCA1-BARD1-BACH1-DNA damage complex II: BRCA1-BARD1-BACH1-DNA damage complex II complex (BACH1-BARD1-BRCA1-MRE11A-NBN-RAD50-RBBP8-TOPBP1) Greenberg et al., Genes Dev 2006
MIPS CORUM BRCA1-BARD1-BACH1-DNA damage complex I: BRCA1-BARD1-BACH1-DNA damage complex I complex (BACH1-BARD1-BRCA1-MLH1-MSH6-TOPBP1) Greenberg et al., Genes Dev 2006
IRef Corum Interaction: Complex of 13 proteins (association, cosedimentation through density gradient) Greenberg et al., Genes Dev 2006
IRef Corum Interaction: Complex of 17 proteins (association, cosedimentation through density gradient) Greenberg et al., Genes Dev 2006
IRef Dip Interaction: TOPBP1 — BRCA1 (physical association, fluorescence microscopy) Liu et al., Mol Cell Biol 2003
IRef Dip Interaction: TOPBP1 — BRCA1 (physical association, fluorescence microscopy) Mäkiniemi et al., J Biol Chem 2001 *