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COA5 — LEP

Text-mined interactions from Literome

O'Rourke et al., J Biol Chem 2002 : However, in the presence of high glucose both insulin and leptin caused a significant increase in the activity of acyl-CoA : cholesterol O-acyltransferase ( ACAT ) combined with a significant reduction in the level of hormone-sensitive lipase (HSL)
Shirai et al., J Nutr Biochem 2004 : Exogenous pyruvate ( 2.5, 5.0, or 10.0 mM ) and malonyl-CoA ( 10, 20, or 40 mM ), substrates and intermediate of fatty acid synthesis, increased leptin release by 11.0 +/- 3.3, 21.5 +/- 5.4, or 61.0 +/- 10.7 %, and 11.1 +/- 3.0, 41.1 +/- 9.7 or 56.7 +/- 7.9 % of the control, respectively
Szkudelski et al., Physiol Res 2007 : The role of mTOR, ATP, cAMP, fatty acids, malonyl-CoA , adenosine and Ca ( 2+ ) in the regulation of leptin secretion from adipocytes is discussed
Kadokawa et al., J Vet Med Sci 2007 : We conclude that, as in monogastrics, malonyl CoA may play a key role in the control of leptin secretion in ruminants
Wein et al., Exp Clin Endocrinol Diabetes 2007 : Taken together, we showed that leptin acutely increases palmitoyl-CoA oxidation rate in liver and in skeletal muscle, which was associated with tissue specific effect on the CPT1 activity as well as on the downstream enzymes of fatty acid oxidation pathways in rat mitochondria and peroxisomes
Gao et al., Proc Natl Acad Sci U S A 2007 : Furthermore, we find that ICV leptin up-regulates the level of malonyl-CoA ( the intermediate of fatty acid biosynthesis ) specifically in the Arc and increases the level of palmitoyl-CoA ( a major product of fatty acid biosynthesis ) specifically in the PVN
Wolfgang et al., Proc Natl Acad Sci U S A 2007 : Regulation of hypothalamic malonyl-CoA by central glucose and leptin ... Finally, we showed that leptin can increase hypothalamic malonyl-CoA and that the increase is additive with glucose administration