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PLD4 — PRKACG

Text-mined interactions from Literome

Mamoon et al., J Pharmacol Exp Ther 1999 : Protein kinase A (PKA) inhibitors H-89 and KT5720 significantly decreased forskolin- and isoproterenol mediated activation of PLD activity ... These results suggest that increasing the concentration of cAMP activates PLD via activation of PKA and that the increased activity of PKA also inhibits cholinergic stimulation of PLD , in part at least by inhibiting the activation of phospholipase C by ACh
Thibault et al., J Leukoc Biol 2002 : The activator of protein kinase A (PKA) , Sp-cAMP inhibited fMLP induced PLD activation and translocation of Arf and RhoA to membranes
Choi et al., Ann N Y Acad Sci 2002 : Here we review the evidence that ( 1 ) the synergistic interactions of cholera toxin and other pharmacological agents on mast cell secretion are attributable to the synergistic activation of PLD via PKA , CaM kinase II, and PKC and ( 2 ) both PLD1 and PLD2 participate in this process
Cohen et al., Dev Biol 2004 : Protein kinase A (PKA) , known to be active in sperm capacitation, and protein kinase C ( PKC ), involved in the acrosome reaction, can both activate PLD and actin polymerization ... We suggest that PKA- and PKC dependent signal transduction pathways can potentially lead to PLD activation ; however, under physiological conditions, actin polymerization depends primarily on PKA activity
Yoon et al., FEBS Lett 2005 : To investigate the involvement of protein kinase A (PKA) , Src, and Ras in 8-Br-cAMP induced PLD activation, we used PKA inhibitor, H89 and Rp-cAMPs, and transfections of DN-Src and DN-Ras ... H-89 and Rp-cAMPs completely blocked 8-Br-cAMP mediated PLD and ERK activation, implying the involvement of PKA in this PLD activation
Breitbart et al., Mol Cell Endocrinol 2006 : Protein kinase A (PKA) and C ( PKC ) can both activate sperm PLD and actin polymerization under in vitro incubation, however under physiological conditions, actin polymerization depends primarily on PKA activity
Vorland et al., Platelets 2008 : Further studies using inhibitors as well as specific activators of protein kinases A and G suggest a role for PKA in the inhibition of thrombin activated PLD
Kessels et al., Biochem J 1993 : Taken together, our results indicate that in human neutrophils : ( i ) PKC activity is not essential for fMLP induced activation of PLD; (ii) PKC activity does play an essential role in the activation of the respiratory burst by fMLP, other than mediating or modulating PLD activation ; ( iii ) there exists a negative-feedback mechanism on fMLP induced PLD activation by concomitant activation of PKA