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FAS — IFNG

Text-mined interactions from Literome

Haynes et al., Cancer Immunol Immunother 1999 (Neoplasms) : The sensitivity of tumour target cells to Fas ligand was further enhanced by treating them with interferon-gamma , a regulator of Fas and downstream signalling components of the Fas pathway
Tillman et al., Clin Cancer Res 1999 (Colonic Neoplasms) : FUra/LV induced cytotoxicity was significantly potentiated by IFN-gamma, reversed by exposure to NOK-1+NOK-2 antibodies, and correlated with a 4-fold induction of Fas expression in the presence of IFN-gamma and significant elevation in expression of FasL
Abreu-Martin et al., Am J Physiol 1999 : IFN-gamma increases expression of Fas on HT-29 cells
Gannot et al., Cell Death Differ 1998 (Sjogren's Syndrome) : IFN-gamma induced an upregulation of Fas receptor expression and pre-treatment of cells with IFN-gamma led to enhanced anti-Fas mediated cell death
Kano et al., Biochem Biophys Res Commun 1999 : Caspase-1 expression was little detected in hepatocytes, and constitutive and IFN-gamma induced mRNA expression of Fas or caspase-3 did not change in between wild type and IRF-1-deficient hepatocytes
Martins et al., Infect Immun 1999 (Chagas Disease) : In the presence of IFN-gamma and absence of NO, although Fas expression was maintained, apoptosis levels were significantly reduced but still higher than those found in splenocytes from uninfected mice, suggesting that Fas-Fas-L interaction could also play a role in apoptosis induction in T. cruzi infected mice
Hiromatsu et al., J Clin Endocrinol Metab 1999 (Graves Disease) : Interferon-gamma induced Fas up-regulation was suppressed by TSH
Ruemmele et al., J Cell Physiol 1999 : The sensitizing effect to FAS induced apoptosis was mediated via TNFalpha- and IFNgamma induced upregulation of FAS expression ( maximally 348 % ) ... In colonic organ cultures, IFNgamma and TNFalpha also enhanced colonocyte FAS expression, resulting in a markedly increased apoptotic response to stimulation of this receptor, as shown by in situ terminal deosyuridine triphosphate nick-end staining
Tsutsui et al., Immunity 1999 (Liver Diseases) : Administration of Propionibacterium acnes ( P. acnes ) upregulated functional Fas expression on macrophages in an IFNgamma dependent manner, and these macrophages became competent to secrete mature IL-18 upon stimulation with FasL
Dörrie et al., Leukemia 1999 (Burkitt Lymphoma) : The regulatory effects of IFNgamma on CD95 expression and CD95 mediated cell death were investigated in three high-risk pro-B acute lymphoblastic leukemia ( ALL ) lines that carry the chromosomal translocation t ( 4 ; 11 ) ( q21 ; q23 )
Blüher et al., Eur J Endocrinol 1999 (Thyroiditis, Autoimmune) : However, in contrast to results of recent in vitro studies, in the BB/W rat Fas/FasL expression is not regulated by IL-2, -4, -6, -10, -12, interferon gamma , and tumor necrosis factor alpha
Luttmann et al., Scand J Immunol 2000 : It has previously been shown that interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) together increase CD95 surface expression on eosinophils ... We therefore investigated whether the increase in CD95 expression mediated by IFN-gamma/TNF-alpha indeed translates into increased, FasL mediated apoptosis of eosinophils ... This increase in CD95/FasL mediated apoptosis was correlated with an IFN-gamma/TNF-alpha mediated increase in CD95 expression
Müschen et al., Immunology 2000 (Breast Neoplasms) : In four breast cancer cell lines, CD95L expression was increased by interferon-gamma (IFN-gamma) , which resulted in higher levels of CD95L-specific apoptosis in co-cultured Jurkat T cells
Kawamura et al., J Dermatol Sci 2000 : These results suggest that LC may acquire the susceptibility to Fas mediated apoptosis through up-regulation of the Fas expression by IFN-gamma derived from activated T cells and that the elimination of LC may be important for preventing excess cutaneous inflammatory diseases
Ueno et al., Hepatology 2000 (Bile Duct Diseases...) : Interferon-gamma augmented Fas expression and Fas mediated cell death, respectively
Badie et al., Exp Neurol 2000 (Glioma) : Flow cytometry was used to quantify the IFN-gamma mediated apoptotic response and Fas and Fas ligand (FasL) expression in two well characterized murine microglia cell lines ( BV-2 and N9 ) ... These findings suggest that in addition to its role as a microglia activator, IFN-gamma may also induce apoptosis of microglia, possibly through simultaneous upregulation of Fas and FasL
Klein et al., Hum Gene Ther 2000 (Insulinoma) : Like pancreatic beta cells, betaTC-3 cells do not constitutively express Fas , but Fas expression can be induced with IL-1 and IFN-gamma
Trautmann et al., J Clin Invest 2000 (Eczema) : KCs normally express low levels of Fas receptor (FasR) that can be substantially enhanced by the presence of IFN-gamma
Matsumura et al., Clin Exp Rheumatol 2000 (Lymphadenitis...) : Our findings suggest that IFN-gamma or TNF-alpha secreted by infiltrating lymphocytes induces ductal Fas expression and ductal apoptosis in sialoadenitis associated with SS
Rescigno et al., J Exp Med 2000 (Inflammation) : Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction : a new role for Fas ligand in inflammatory responses
Shin et al., Cancer Immunol Immunother 2001 (Carcinoma, Hepatocellular...) : IFN-gamma increased the mRNA expression of Fas, TRAIL and caspase-1, and surface Fas was also increased
Bergmann-Leitner et al., Cell Immunol 2001 (Carcinoma...) : The IFN-gamma promoted significant upregulation of Fas on the surface of colon carcinoma cells and sensitized these targets to Fas mediated apoptosis and Ag-specific CD8 ( + ) cytotoxic T lymphocyte ( CTL ) -mediated lysis involving a Fas based effector mechanism
Wigginton et al., J Clin Invest 2001 (Carcinoma, Renal Cell...) : The IL-12/IL-2 combination synergistically enhances cell surface FasL expression on CD8 ( + ) T lymphocytes in vitro and induces Fas and FasL expression within tumors via an IFN-gamma dependent mechanism in vivo
Annicchiarico-Petruzzelli et al., Med Pediatr Oncol 2001 (Neuroblastoma) : To evaluate a possible role of the CD95/CD95L system in human neuroblastoma ( NB ) cells, we investigated the constitutive and interferongamma (INFgamma) induced expression of CD95 and CD95L, and CD95 mediated cell death in the SK-N-BE ( 2 ) cell line ... Modulation of CD95/CD95L expression and triggering of an autocrine apoptotic mechanism by IFNgamma suggest a potential role for INFgamma as a therapeutic agent for NB
Zennadi et al., Cell Immunol 2001 (Melanoma) : Parental autologous and HLA-DR matched allogeneic melanoma cell lines, displaying low levels of HLA-DR antigens, induced Th2 proliferation and cytokine release, but were insensitive to lysis prior to upregulation of HLA-DR and Fas antigens by IFN-gamma
Abu-Helu et al., J Autoimmun 2001 (Sjogren's Syndrome) : Dexamethasone inhibited the upregulation of Fas and FasL by IFN-gamma and the induction of SGEC apoptosis and detachment by anti-Fas mAb or IFN-gamma
Shimada et al., J Gastroenterol Hepatol 2001 (Adenocarcinoma...) : Flow cytometric analysis demonstrated that IFN-gamma significantly enhanced Fas Ag expression
Trautmann et al., J Allergy Clin Immunol 2001 (Acute Disease...) : IFN-gamma released from activated T cells upregulates Fas on ke-ratinocytes, which renders them susceptible to apoptosis
Via et al., J Immunol 2001 (Acute Disease...) : Moreover, an in vivo blockade of TNF-alpha preferentially inhibited the production of IFN-gamma and blocked IFN-gamma dependent up-regulation of Fas ; however, cytokines such as IL-10, IL-6, or IL-4 were not inhibited
Lee et al., J Gastroenterol Hepatol 2002 (Neoplasm Metastasis...) : The data indicate that the FasL expression of gastric cancer cells supports a ` counterattack theory ' in gastric cancer cells and that the upregulation of Fas by IFN-gamma in SNU-638 may accelerate the apoptosis pathway through the Fas and FasL interaction between gastric cancer cells and immune cells
Hall et al., Gene Ther 2002 (Prostatic Neoplasms) : After demonstrating that Ad.HSV-tk/GCV and Ad.mIL-12 induced IFN-gamma independently up-regulated expression of FasL and Fas , respectively, studies examined tumor cell mediated death through Fas/FasL induced apoptosis as a mechanism of primary tumor growth suppression
Aschkenazi et al., Biol Reprod 2002 : IFN-gamma and TNFalpha promote Fas expression and sensitivity, whereas IL-6 and IL-10 increase the resistance of trophoblast cells to Fas mediated apoptosis
Müllbacher et al., J Immunol 2002 (Leukemia L1210) : This Fas up-regulation on initially Fas negative target cells is not mediated by TCR-MHC/peptide signaling per se, but by secreted IFN-gamma from Tc cells after Ag engagement
Dörrie et al., Cytokine 2002 (Leukemia, B-Cell) : Interferon-gamma increases the expression of glycosylated CD95 in B-leukemic cells : an inducible model to study the role of glycosylation in CD95 signalling and trafficking ... However, the IFN-gamma induced increases of CD95 on the cell surface were not altered by treatment with any of the glycosidase inhibitors, suggesting that the generation of complex oligosaccharide structures is not required for trafficking of CD95, but may instead be used as a mechanism of partially blocking CD95 signalling in these cells
Foerster et al., Scand J Immunol 2002 (Asthma) : Only IFN-gamma enhanced constitutive CD95 expression
Li et al., Am J Pathol 2002 : Interferon-gamma augments CD95 ( APO-1/Fas ) and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95 mediated apoptosis ... We have examined the effects of interferon (IFN)-gamma on expression and function of CD95 ( APO-1/Fas ) and associated proteins in cultured human umbilical vein and dermal microvascular endothelial cells ( HUVEC and HDMEC, respectively ) ... Unstimulated cells express only low levels of CD95 ; IFN-gamma produces a time- and concentration dependent increase of CD95 in both cell types at the mRNA and cell surface protein levels ... We conclude that IFN-gamma induces sensitivity of endothelium to CD95L mediated apoptosis, and that this response may result from increased expression of CD95 and/or pro-caspase-8
Zheng et al., Di Yi Jun Yi Da Xue Xue Bao 2002 : To investigate effect of interferon-gamma (IFN-gamma) on Fas expression and Fas mediated apoptosis in tumor cell lines ... Fas expression was up-regulated by IFN-gamma ( P < 0.05 ), which alone was enough to induce apoptosis in tumor cells and increase the susceptibility of them to anti-Fas antibodies ... IFN-gamma induced Fas expression up-regulation and tumor cell apoptosis in a time dependent manner
Abe et al., Gan To Kagaku Ryoho 2002 (Bile Duct Neoplasms) : However, IFN-gamma did not affect the expression of Fas in HuH28 cells ... These results suggest that Fas was expressed, apoptosis was induced by CH-11 and the induction of apoptosis was enhanced by IFN-gamma in human bile duct carcinoma cells
Sindhi et al., J Immunol Methods 2003 : PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ), ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2, TNF-alpha, and IFN-gamma was inhibited by CsA, and minimally by SRL, and ( 2 ) the two agents inhibited pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and CD95 , but not CD86 ( ICAM-1, Fas antigen, and B7.2 ), synergistically
Ma et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2002 : Tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) further increased the CD95 expression induced by positive cytokines
Yamaoka-Tojo et al., Coron Artery Dis 2003 : IFN-gamma up-regulated Fas mRNA levels
Zhang et al., Cell Death Differ 2003 : Blocking TRAIL and CD95L significantly enhance IFN-gamma production in vitro
Catalan et al., Kidney Int 2003 (Peritonitis) : IFNgamma increased the cell surface expression of Fas and the sensitivity of mesothelial cells to FasL induced apoptosis
Hayashi et al., Apoptosis 1998 : Interferon-gamma enhanced the expression of Fas antigen in all of the cell lines examined
Turner et al., Cancer Chemother Pharmacol 2004 (Colorectal Neoplasms) : Our results showed that IFN-gamma upregulates Fas in PBMC in vivo and in HT29 cells in vitro at tolerable, clinically relevant exposures and that monitoring IFN-gamma pharmacokinetics/pharmacodynamics may be warranted in IFN-gamma clinical use
Thomas et al., Diabetes 2004 (Diabetes Mellitus, Type 1...) : IL-1 action was not required for induction of class I major histocompatibility complex or Fas by TNF and IFN-gamma
Welsh et al., Hematol J 2004 (Anemia, Aplastic) : IFN-gamma/TNF-alpha induced upregulation of CD95 on both normal and aplastic CD34+ cells, although the basal level of CD95 expression was increased in aplastic cells
Xiao et al., J Huazhong Univ Sci Technolog Med Sci 2003 (Graft vs Host Disease) : However, IFN-gamma up-regulated Fas expression of CD34+ cells and increased the sensibility of CD34+ cells to soluble FasL ( sFasL ) ; IL-2 showed no such effect
Augstein et al., Endocrinology 2004 (Diabetes Mellitus, Type 1...) : The effect of FasL on NIT-1 cells was evident during and after the induction of Fas expression by IL-1beta and IFNgamma
Chong et al., J Immunol 2004 (Diabetes Mellitus, Type 1...) : SOCS-1 appeared to protect at least in part by inhibiting TNF- and IFN-gamma induced Fas expression on beta cells
De Rose et al., J Leukoc Biol 2004 (Asthma...) : We investigated the effect of recombinant IFN-gamma on proliferation, Fas/Fas ligand (FasL) expression, and apoptosis in allergen stimulated peripheral blood mononuclear cells obtained from atopic, asthmatic patients and nonatopic, control subjects ... IFN-gamma induced an increase in the expression of Fas and FasL by allergen stimulated CD4+ T cells from asthmatic patients and caused the apoptosis of these cells
Buntinx et al., J Neurosci Res 2004 : In addition to direct cytotoxic effects, IFN-gamma and TNF-alpha also enhance the expression of Fas , TNFR1, and MHC class I molecules in both cell lines
Puliaev et al., J Immunol 2004 (Acute Disease...) : Thus, both IFN-gamma dependent induction of Fas/FasL and IFN-gamma independent induction of perforin contribute to CTL mediated elimination of host B cells in AGVHD
Zhou et al., Am J Physiol Gastrointest Liver Physiol 2004 (Intestinal Diseases) : This difference in IL-10 KO mice was associated with an increase in serum tumor necrosis factor-alpha and interferon-gamma levels and with an increase in Fas expression on fresh, isolated, small intestinal epithelial cells
Chang et al., J Cell Biochem 2004 : Immunobloting reveals that LIGHT/IFN-gamma could induce p38 MAPK activity, Bak and Fas expression, but down-regulate Mcl-1
Jhala et al., Arch Pathol Lab Med 2005 (Bile Duct Neoplasms...) : In addition, interferon gamma induces Fas expression in Fas negative cholangiocarcinoma cells and makes them susceptible to apoptosis
Perl et al., Am J Pathol 2005 (Disease Models, Animal...) : Only Fas-siRNA markedly diminished lung tissue tumor necrosis factor-alpha, IL-6, IL-10, interferon-gamma , IL-12, and caspase-3 activity
Rosner et al., Am J Pathol 2006 (Atherosclerosis) : IFN-gamma also increased Fas induced apoptosis in vivo 7.5- to 15-fold ( P < 0.05 ) in human arteries transplanted into immunodeficient mice, accompanied by increased Fas and phospho-Ser727-Stat1
McCullough et al., Int J Exp Pathol 2007 : For the first time in primary hepatocytes, we show that IFNgamma mediated apoptotic signalling requires the cell surface interaction of CD95 and its ligand, and we demonstrate that IFNgamma induces soluble CD95 ligand release from hepatocyte monolayers
Yang et al., J Immunol 2007 (Sarcoma) : In addition, disruption of constitutively expressed IRF8 function diminished JAK1 expression and thereby inhibited IFN-gamma initiated induction of STAT1 phosphorylation, which in turn, blocked IFN-gamma induced Fas up-regulation
Koide et al., Clin Exp Immunol 2007 : IFN-gamma and LPS augmented cell surface expression of Fas , but not tumour necrosis factor (TNF) receptor 1
Augstein et al., Diab Vasc Dis Res 2008 : Induction of Fas by IL-1beta/IFN-gamma coupled with activation by Super-FasL augmented cytokine induced cell death
Solarewicz-Madejek et al., Clin Exp Allergy 2009 (Asthma...) : IFN-gamma and TNF-alpha up-regulated TNFR1, TNFR2, Fas and membrane FasL on SMC
Kondo et al., Immunology 2009 (Myositis) : In vitro culturing of muscle cells with the proinflammatory cytokines interferon-gamma , tumour necrosis factor-alpha, and interleukin (IL)-1beta synergistically increased Fas expression, susceptibility to Fas mediated apoptosis, and the expression of cytoplasmic caspases 8 and 3
Zhang et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2013 : IFN-gamma up-regulated the expression of HMGB1, SREBP-1, FAS mRNA and protein time-dependently ; Transfection of MMC with HMGB1 siRNA resulted in the suppression of SREBP-1, FAS protein levels induced by IFN-gamma , following with decrease of lipid deposition
Sumimoto et al., Cell Immunol 1994 : IFN-gamma increased the surface expression of Fas antigen and susceptibility to anti-Fas Ab-induced cell death of B104 and U937 cells
Nagafuji et al., Blood 1995 : IFN-gamma and TNF-alpha had a synergistic effect on the induction of Fas , when both cytokines were added to the culture ... These observations indicate that IFN-gamma and/or TNF-alpha, well known as negative hematopoietic regulators, induce functional Fas on hematopoietic progenitor cells
Maciejewski et al., Br J Haematol 1995 (Anemia, Aplastic...) : Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), potent inhibitors of haemopoiesis, enhance Fas receptor expression on bone marrow ( BM ) CD34+ cells, and both cytokines render haemopoietic progenitor cells susceptible to Fas mediated inhibition of colony formation due to the induction of apoptosis
Hakuno et al., Endocrinology 1996 : Finally, we found that interferon-gamma increased Fas expression on granulosa cells in vitro
Nagafuji et al., Nihon rinsho. Japanese journal of clinical medicine 1996 : However, interferon-gamma(IFN-gamma) and/or tumor necrosis factor-alpha (TNF-alpha) induced the expression of Fas after 48 hours of serum-free culture
Bárcena et al., Blood 1996 : Tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) further increased the CD95 expression induced by KL+GM-CSF
Denfeld et al., Eur J Immunol 1996 (Psoriasis...) : Furthermore, ligation of CD40 via soluble gp39, the CD40 ligand, enhances intercellular adhesion molecule (ICAM)-1 and Bcl-x up-regulation on IFN-gamma stimulated KC, but not lymphocyte function associated antigen ( LFA)-3, B7-2, HLA-DR, or Fas expression
Cai et al., Int J Cancer 1996 : While MCF7 and R-A1 cells were killed by anti-Fas in the presence of IFN-gamma , MCF7Adr was found to be resistant to Fas mediated apoptosis
Selleri et al., Blood 1997 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : We have previously shown that IFN-gamma induces Fas-R expression on CD34+ cells ; in this study, we investigated whether IFN-alpha induces Fas-R expression on CML progenitor cells
Nagafuji et al., Leukemia & lymphoma 1996 : However, interferon-gamma (IFN-gamma) and/or tumor necrosis factor-alpha (TNF-alpha) induced dose dependent expression of both Fas mRNA and Fas protein on the surface of CD34+ cells after 48 hours of serum-free culture
Sato et al., Br J Haematol 1997 : CD34+ cell Fas-R expression was increased by IFN-gamma and TNF-alpha
Sato et al., Blood 1997 : IFN-gamma both inhibits cell cycling and induces expression of the Fas-receptor , resulting in subsequent apoptosis of hematopoietic progenitor cells
Selleri et al., Br J Haematol 1997 : Fas-receptor (Fas-R) expression can be stimulated by IFN-gamma and TNF-alpha ... Transactivation of iNOS, and possibly Fas-R promoters, by interferon regulatory factor-1 expressed in response to IFN-gamma may be a part of the iNOS transduction pathway
Dai et al., Blood 1998 : Fas ligand is present in human erythroid colony forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis
Conceição-Silva et al., Eur J Immunol 1998 (Disease Susceptibility...) : Furthermore, macrophages infected with L. major in vitro up-regulate their surface expression of Fas in response to IFN-gamma and as a result become susceptible to CD4+ T cell induced apoptotic death
Xu et al., Cancer Res 1998 (Leukemia, T-Cell) : IFN-gamma induces cell growth inhibition by Fas mediated apoptosis : requirement of STAT1 protein for up-regulation of Fas and FasL expression ... Here we report that IFN-gamma up-regulated the expression of Fas and Fas ligand (FasL) on HT29 cells, a human colon adenocarcinoma cell line, and subsequently induced apoptosis of these cells ... We further show that IFN-gamma up-regulated the expression of Fas and FasL in STAT1 transfected U3A cells but not in STAT1-deficient U3A cells
Lutz et al., Oncogene 1998 (Neuroblastoma) : First, IFNgamma increased the CD95 cell surface expression while MycN enhanced the cellular susceptibility for the CD95 mediated death signal
Shustov et al., J Immunol 1998 (Acute Disease...) : Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production ... Thus, in this in vivo model of alloantigen immune responsiveness, Fas/FasL up-regulation is critically dependent on Ag-specific ( donor ) CD8+ T cell activation and IFN-gamma production
Kawakami et al., J Lab Clin Med 1998 : About 30 % of unstimulated PBLs expressed Fas , and the expression was augmented by interleukin-1beta (IL-1beta), IL-2, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) , or PMA plus ionomycin
Moers et al., Int J Cancer 1999 (Carcinoma, Squamous Cell...) : In human primary cell lines from a squamous cell carcinoma (SCC) of the vulva, the effect of cisplatin ( CDDP ) and IFNgamma on the expression of CD95L and its 2 receptor isoforms, CD95 transmembrane (CD95tm) and CD95 soluble receptor, was studied at the mRNA and protein levels