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MAPK12 — TYR

Text-mined interactions from Literome

Relou et al., J Biol Chem 2003 : Inhibition of Tyr-phosphatases ( vanadate ) increases Tyr phosphorylated PECAM-1 and blocks the activation of p38MAPK
Mapes et al., EMBO J 2004 (MAP Kinase Signaling System) : The yeast high osmolarity glycerol ( HOG ) pathway signals via the Pbs2 MEK and the Hog1 MAPK , whose activity requires phosphorylation of Thr and Tyr in the activation loop
Hata et al., J Biochem 2005 (Melanoma, Experimental) : Inhibition of p38 MAPK by SB203580 blocked tyrosinase induction by lupeol, but did not influence the disruption of stress fiber assembly or the dephosphorylation of cofilin
Schlaepfer et al., J Biol Chem 2007 : Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha stimulated MAPK activation and IL-6 production
Hirata et al., Bioorg Med Chem 2007 (Melanoma) : These results suggested that cubebin increased melanogenesis in B16 cells through the enhancement of tyrosinase expression mediated by activation of p38 MAPK
Ahn et al., Arch Dermatol Res 2008 (MAP Kinase Signaling System) : Furthermore, p38 MAPK functionally regulated the LPS induced melanin formation in melanocytes ; a p38 MAPK inhibitor, SB203580, almost completely attenuated the LPS mediated up-regulation of melanin synthesis and induction of MITF and tyrosinase expression
Jiang et al., Life Sci 2009 (Melanoma, Experimental) : Furthermore, Western blot analysis revealed that THSG elevated the level of phosphorylation of p38 mitogen activated protein kinase ( p38 MAPK ) significantly at 1-6 h ; a p38 MAPK inhibitor, SB203580, almost completely attenuated the THSG mediated up-regulation of melanin synthesis and induction of MITF and tyrosinase expression
Zhou et al., J Ethnopharmacol 2012 (Melanoma, Experimental) : The special p38 MAPK inhibitor, SB203580, and protein kinase A (PKA) inhibitor, H89, both attenuated the AVE induced up-regulation of MITF and tyrosinase expression in B16F10 cells and NHMC ... AVE exerts its improving effect on melanogenesis mainly by p38 MAPK activation and MITF induction of tyrosinase
Villareal et al., Planta Med 2013 : The increase in the tyrosinase mRNA expression was most likely due to the inhibited mitogen activated protein kinase phosphorylated extracellular signal regulated kinases 1 and 2 activation
Baxter et al., Eur J Biochem 1995 : ( 2 ) Tyr490 phosphorylation ( but not inositol phospholipid 3-kinase activation ) is also required for strong and sustained activation of mitogen-activated-protein kinase and neuronal differentiation, while the smaller and more transient activation of mitogen-activated-protein kinase, produced by the activation of phospholipase C-gamma 1 is insufficient to trigger the neuronal differentiation of PT-R cells
Côté et al., Endocr Res 1998 : Moreover, pre-incubation of the cells with genistein ( Tyr-kinase inhibitor ) and PD 098059 ( a MAPK inhibitor ) did not affect InsPs production or aldosterone secretion induced by Ang II or AVP