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Lai et al., J Cell Physiol 2005
(MAP Kinase Signaling System) :
We have examined the role of integrins and mitogen activated protein ( MAP ) kinases in Ihh mRNA regulation in CFK-2 chondrocytic cells ... These studies demonstrated that activation of ERK1/2 or p38 MAPK increased Ihh mRNA levels ... Our data demonstrate the central role of MAPK in the regulation of Ihh in CFK-2 cells
Yoon et al., Development 2006
(Osteochondrodysplasias) :
These studies indicate that BMP signaling is required to promote Ihh expression, and to inhibit activation of STAT and ERK1/2 MAPK , key effectors of FGF signaling