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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to RAC1

CTNND1 — RAC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hsia et al., J Cell Biol 2003 (Neoplasm Invasiveness...) : Cell invasion was linked to transient FAK accumulation at lamellipodia, formation of a FAK-Src-p130Cas-Dock180 signaling complex, elevated Rac and c-Jun NH2-terminal kinase activation , and increased matrix metalloproteinase expression and activity
Hudson et al., Cell Microbiol 2005 : Under conditions of low concentrations of ECM, invasin was found to be the dominant adhesin, promoting high levels of phagocytosis coincident with robust and sustained activation of the protein tyrosine kinases Fak and Pyk2, phosphorylation of the adaptor molecule Cas and activation of the small GTPase Rac1
Liu et al., J Cell Biol 2006 : Rac1 activity, which was induced by E-cadherin engagement specifically at intermediate seeding densities, was required for the cadherin stimulated proliferation, and the control of Rac1 activation by E-cadherin was mediated by p120-catenin
Hou et al., J Biol Chem 2006 : Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking
Smith et al., J Cell Biol 2008 (Neoplasm Invasiveness) : We show that uPAR cooperates with integrin complexes containing beta ( 3 ) integrin to drive formation of the p130Cas-CrkII signaling complex and activation of Rac , resulting in a Rac-driven elongated-mesenchymal morphology, cell motility, and invasion
Sharma et al., BMC cell biology 2008 : Phosphorylation of p130Cas initiates Rac activation and membrane ruffling ... Phosphorylation of p130Cas in SYF cells led to activation of Rac1 and increased membrane ruffling and lamellipodium formation, events associated with cell migration
Gupta et al., J Cell Sci 2009 : We found for the first time that specific ligation of integrin alpha9beta1 rapidly activates Src tyrosine kinase, with concomitant tyrosine phosphorylation of p130Cas and activation of Rac-1
Johnson et al., J Biol Chem 2010 (Breast Neoplasms) : HER2/ErbB2 induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42
Birukova et al., Exp Cell Res 2011 (Disease Models, Animal...) : OxPAPC also induced Rac dependent tyrosine phosphorylation and association of p190RhoGAP with AJ protein p120-catenin
Vanden Borre et al., Cell Signal 2011 : Using R743A BCAR3, a point mutant that has lost the ability to bind p130Cas, we find that BCAR3-p130Cas complex formation is not required for BCAR3 mediated anti-estrogen resistance, Rac activation or discohesion of epithelial breast cancer cells
Wang et al., BMC cancer 2011 (Astrocytoma...) : In addition, CTNND2 overexpression promoted proliferation, invasion and Rac1 activity of U251 astrocytoma cells
Zhang et al., Am J Pathol 2013 (Cell Transformation, Neoplastic...) : These data suggested that Rac1 and Cdc42 coactivation was essential to smoke promoted cell migration in the presence of p120ctn , whereas migration proceeded via Rac1 alone in the absence of p120ctn
Dolfi et al., Proc Natl Acad Sci U S A 1998 : JNK activation by Cas and Crk was effectively blocked by a dominant negative form of Rac , suggesting for a linear pathway from the Cas-Crk-complex to the Rac-JNK activation