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EGR1 — NAB2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGR1 — NAB2 (direct interaction, two hybrid) Svaren et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: EGR1 — NAB2 (in vivo) Svaren et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: EGR1 — NAB2 (two hybrid) Svaren et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: EGR1 — NAB2 (in vitro) Svaren et al., Mol Cell Biol 1996*
• IRef Innatedb Interaction: EGR1 — NAB2 (unknown, -) Kubosaki et al., Genome Biol 2009
• IRef Innatedb Interaction: EGR1 — NAB2 (unknown, -) Tang et al., Electrophoresis 2010
• IRef Ophid Interaction: EGR1 — NAB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Houston et al., Biochem Biophys Res Commun 2001 : NAB2 blocks Egr-1 activation of the tissue factor ( TF ) promoter, Egr-1 stimulated production of PDGF-AB, HGF, TGFbeta(1), and VEGF and the endogenous expression of PDGF-AB and TGFbeta(1)
Fu et al., J Biol Chem 2002 : In addition, overexpression of a constitutively active form of Egr-1 by adenoviral gene transfer in VSMC dramatically induced PPARgamma1 gene expression by 6-8-fold, and overexpression of NAB2 , a potent negative feedback regulator of Egr-1 , abrogated the growth factor- and cytokine induced PPARgamma1 expression in VSMC
Kumbrink et al., J Biol Chem 2005 : In addition Egr-1 activates the Nab2 promoter in a pattern similar to phorbol esters, suggesting that Egr-1 is a major inducer of protein kinase C-mediated Nab2 induction ... Depletion of Egr-1 by each of two distinct Egr-1 short interfering RNAs reduces Nab2 expression and inducibility, confirming that Egr-1 is an important regulator of Nab2 expression ... Transfection experiments show that Egr-1 induced Nab2 promoter activity is itself repressed by Nab2
Schweighofer et al., Clin Hemorheol Microcirc 2007 : Similarly, NAB2 , a corepressor of EGR-1, is induced by EGR-1 and limits EGR-1 effects
Kumbrink et al., J Cell Biochem 2010 : EGR1 , EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin ... EGR1, EGR2 , and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin ... In melanoma and carcinoma cells EGR1 activates NAB2 expression ... Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells ... EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2 ... EGR1- , EGR2-, and EGR3 induced NAB2 promoter activity is mediated through similar cis-regulatory elements and the activation by each EGR is repressed by NAB2 ... EGR1-, EGR2-, and EGR3 induced NAB2 promoter activity is mediated through similar cis-regulatory elements and the activation by each EGR is repressed by NAB2 ... Kinetic studies suggest that induction of EGR1 leads to low NAB2 expression, while EGR2 and EGR3 are necessary for maximal and sustained expression ... Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1 , EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop ... Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2 , and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop
Kumbrink et al., Neoplasia (New York, N.Y.) 2012 (Breast Neoplasms) : p130 ( Cas ) depletion using siRNA showed that, in tamoxifen-sensitive MCF-7 cells, p130 ( Cas ) regulates EGR1 and NAB2 expression, whereas in the derivative tamoxifen-resistant TAM-R cells, only NAB2 levels were influenced
Svaren et al., Mol Cell Biol 1996 (Leiomyoma...) : NAB2 represses the activity of both NGFI-A and Krox20, and its expression is regulated by some of the same stimuli that induce NGFI-A expression, including serum stimulation of fibroblasts and nerve growth factor stimulation of PC12 cells