Blood 1996,
PMID: 8611693
Weiler, S R; Mou, S; DeBerry, C S; Keller, J R; Ruscetti, F W; Ferris, D K; Longo, D L; Linnekin, D
Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine phosphorylation of JAK2 in human and murine cell lines, as well as in normal human progenitor cells. JAK2 and c-kit were associated in unstimulated cells with further recruitment of JAK2 to the c-kit receptor complex after SCF stimulation. Treatment of cells with JAK2 antisense oligonucleotides resulted in a 46% decrease in SCF-induced proliferation. These data demonstrate that SCF induces tyrosine phosphorylation of JAK2 and suggest that JAK2 is a component of the SCF signal transduction pathway.
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Text Mining Data
SCF → JAK2: "
These data demonstrate that
SCF induces tyrosine phosphorylation of
JAK2 and suggest that JAK2 is a component of the SCF signal transduction pathway
"
Manually curated Databases
In total, 41 gene pairs are associated to this article in curated databases