Gene interactions and pathways from curated databases and text-mining
Cell 1989, PMID: 2788034

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.

Taga, T; Hibi, M; Hirata, Y; Yamasaki, K; Yasukawa, K; Matsuda, T; Hirano, T; Kishimoto, T

Interleukin-6 mediates pleiotropic functions in various types of cells through its specific receptor (IL-6-R), the cDNA of which has already been cloned. We report here that an 80 kd single polypeptide chain (IL-6-R) is involved in IL-6 binding and that IL-6 triggers the association of this receptor with a non-ligand-binding membrane glycoprotein, gp130. The association takes place at 37 degrees C within 5 min and is stable for at least 40 min in the presence of IL-6, but does not occur at 0 degree C. Human IL-6-R can associate with a murine gp130 homolog and is functional in murine cells. Mutant IL-6-R lacking the intracytoplasmic portion is functional, suggesting that the two polypeptide chains interact to involve their extracellular portion. In fact, a soluble IL-6-R lacking the transmembrane and intracytoplasmic domains can associate with gp130 in the presence of IL-6 and mediate its function. These findings indicate that the complex of IL-6 and IL-6-R can interact with a non-ligand-binding membrane glycoprotein, gp130, extracellularly and can provide the IL-6 signal.

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Text Mining Data

glycoprotein → IL-6: " We report here that an 80 kd single polypeptide chain ( IL-6-R ) is involved in IL-6 binding and that IL-6 triggers the association of this receptor with a non-ligand binding membrane glycoprotein , gp130 "

gp130 → IL-6: " In fact, a soluble IL-6-R lacking the transmembrane and intracytoplasmic domains can associate with gp130 in the presence of IL-6 and mediate its function "

Manually curated Databases

  • IRef Biogrid Interaction: IL6ST — IL6R (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IL6 — IL6R (physical association, affinity chromatography technology)
  • IRef Hprd Interaction: IL6R — IL6ST (in vitro)
  • IRef Innatedb Interaction: IL6ST — IL6R (unknown, -)
  • IRef Ophid Interaction: IL6ST — IL6R (aggregation, confirmational text mining)
  • NCI Pathway Database IL6-mediated signaling events: IL6 (IL6) → IL6/IL6RA complex (IL6-IL6R) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database IL6-mediated signaling events: IL6 (IL6) → IL6RA (IL6R) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → IL6RA (IL6R) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database IL6-mediated signaling events: PTPEC (PTPRE) → IL6/IL6RA complex (IL6-IL6R) (modification, inhibits)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: PTPEC (PTPRE) → IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4) (modification, inhibits)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: PTPEC (PTPRE) → gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4) (modification, inhibits)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4) → gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 complex (IL6-IL6R-IL6ST-JAK2-LMO4) → IL6/IL6RA complex (IL6-IL6R) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 complex (IL6-IL6R-IL6ST-JAK2-LMO4) → gp130 (dimer)/JAK2/JAK2/LMO4 complex (JAK2-IL6ST-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → gp130 (dimer)/JAK2/JAK2/LMO4 complex (JAK2-IL6ST-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4) → PTPEC (PTPRE) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4) → IL6/IL6RA complex (IL6-IL6R) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: PTPEC (PTPRE) → IL6/IL6RA complex (IL6-IL6R) (modification, inhibits)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: PTPEC (PTPRE) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) (modification, inhibits)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • Reactome Reaction: IL6 → JAK1 (reaction)
  • Reactome Reaction: IL6R → JAK1 (indirect_complex)
  • Reactome Reaction: IL6 → IL6R (direct_complex)
  • Reactome Reaction: IL6ST → IL6R (indirect_complex)
  • Reactome Reaction: JAK2 → IL6R (reaction)
  • Reactome Reaction: IL6R → JAK2 (indirect_complex)
  • Reactome Reaction: IL6R → IL6 (reaction)
  • Reactome Reaction: JAK1 → IL6R (reaction)
  • Reactome Reaction: IL6ST → IL6 (reaction)
  • Reactome Reaction: IL6R → IL6ST (reaction)
  • Reactome Reaction: IL6R → JAK2 (reaction)
  • Reactome Reaction: JAK2 → IL6R (indirect_complex)
  • Reactome Reaction: IL6 → JAK1 (indirect_complex)
  • Reactome Reaction: IL6R → IL6ST (indirect_complex)
  • Reactome Reaction: IL6ST → IL6R (reaction)
  • Reactome Reaction: IL6R → IL6 (direct_complex)
  • Reactome Reaction: IL6R → JAK1 (reaction)
  • Reactome Reaction: IL6ST → IL6 (indirect_complex)
  • Reactome Reaction: IL6 → JAK2 (reaction)
  • Reactome Reaction: IL6 → IL6R (reaction)
  • Reactome Reaction: JAK1 → IL6R (indirect_complex)
  • Reactome Reaction: IL6 → JAK2 (indirect_complex)
In total, 31 gene pairs are associated to this article in curated databases