Human Gene ZNF552 (ENST00000391701.1_7) from GENCODE V47lift37

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Description: zinc finger protein 552 (from RefSeq NM_024762.3)
Gencode Transcript: ENST00000391701.1_7
Gencode Gene: ENSG00000178935.5_8
Transcript (Including UTRs)
Position: hg19 chr19:58,318,450-58,326,281 Size: 7,832 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr19:58,319,408-58,326,111 Size: 6,704 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:58,318,450-58,326,281)			mRNA (may differ from genome)		Protein (407 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZN552_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 552; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 9 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain. SEQUENCE CAUTION: Sequence=BAB15093.1; Type=Frameshift; Positions=388;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003520 Cyclophosphamide D016572 Cyclosporine D004317 Doxorubicin D005472 Fluorouracil D008748 Methylcholanthrene D017239 Paclitaxel D011794 Quercetin D012643 Selenium

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 13.04 RPKM in Bladder Total median expression: 128.24 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-58.70	170	-0.345	Picture	PostScript	Text
3' UTR	-319.20	958	-0.333	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on Q9H707


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045892 negative regulation of transcription, DNA-templated Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AK025256 - Homo sapiens cDNA: FLJ21603 fis, clone COL07238. BC017460 - Homo sapiens zinc finger protein 552, mRNA (cDNA clone IMAGE:4864067). BC046237 - Homo sapiens zinc finger protein 552, mRNA (cDNA clone IMAGE:5455828), partial cds. BC062982 - Homo sapiens zinc finger protein 552, mRNA (cDNA clone IMAGE:6574426), partial cds. BC082767 - Homo sapiens zinc finger protein 552, mRNA (cDNA clone IMAGE:6480121), partial cds. AK097041 - Homo sapiens cDNA FLJ39722 fis, clone SMINT2014480, highly similar to Homo sapiens zinc finger protein 552 (ZNF552), mRNA. AK225219 - Homo sapiens mRNA for zinc finger protein 552 variant, clone: COL07238. JD535810 - Sequence 516834 from Patent EP1572962. JD092147 - Sequence 73171 from Patent EP1572962. JD347764 - Sequence 328788 from Patent EP1572962. JD312557 - Sequence 293581 from Patent EP1572962. JD064591 - Sequence 45615 from Patent EP1572962. JD242876 - Sequence 223900 from Patent EP1572962. JD203735 - Sequence 184759 from Patent EP1572962. JD071914 - Sequence 52938 from Patent EP1572962. JD397975 - Sequence 378999 from Patent EP1572962. JD070286 - Sequence 51310 from Patent EP1572962. JD514133 - Sequence 495157 from Patent EP1572962. JD151011 - Sequence 132035 from Patent EP1572962. JD120062 - Sequence 101086 from Patent EP1572962. JD463189 - Sequence 444213 from Patent EP1572962. JD213231 - Sequence 194255 from Patent EP1572962. JD407625 - Sequence 388649 from Patent EP1572962. JD256814 - Sequence 237838 from Patent EP1572962. JD059625 - Sequence 40649 from Patent EP1572962. JD152303 - Sequence 133327 from Patent EP1572962. JD526343 - Sequence 507367 from Patent EP1572962. JD353036 - Sequence 334060 from Patent EP1572962. JD213230 - Sequence 194254 from Patent EP1572962. JD110073 - Sequence 91097 from Patent EP1572962. JD275354 - Sequence 256378 from Patent EP1572962. JD518757 - Sequence 499781 from Patent EP1572962. JD375425 - Sequence 356449 from Patent EP1572962. JD518756 - Sequence 499780 from Patent EP1572962. JD316235 - Sequence 297259 from Patent EP1572962. JD292256 - Sequence 273280 from Patent EP1572962. JD411374 - Sequence 392398 from Patent EP1572962. JD049156 - Sequence 30180 from Patent EP1572962. JD373574 - Sequence 354598 from Patent EP1572962. AK293445 - Homo sapiens cDNA FLJ53972 complete cds, highly similar to Homo sapiens zinc finger protein 552 (ZNF552), mRNA. AB528918 - Synthetic construct DNA, clone: pF1KE0708, Homo sapiens ZNF552 gene for zinc finger protein 552, without stop codon, in Flexi system. JD314815 - Sequence 295839 from Patent EP1572962. JD335047 - Sequence 316071 from Patent EP1572962. JD360055 - Sequence 341079 from Patent EP1572962. JD360429 - Sequence 341453 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9H707 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: B3KUE9, NM_024762, Q6P5A6, Q9H707, uc318unh.1, uc318unh.2, ZN552_HUMAN UCSC ID: ENST00000391701.1_7 RefSeq Accession: NM_024762.3 Protein: Q9H707 (aka ZN552_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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