Human Gene ZNF518A (ENST00000316045.10_3) from GENCODE V47lift37

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Description: zinc finger protein 518A, transcript variant 11 (from RefSeq NM_001330738.1)
Gencode Transcript: ENST00000316045.10_3
Gencode Gene: ENSG00000177853.15_10
Transcript (Including UTRs)
Position: hg19 chr10:97,890,054-97,923,515 Size: 33,462 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr10:97,916,080-97,920,530 Size: 4,451 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:97,890,054-97,923,515)			mRNA (may differ from genome)		Protein (1483 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Z518A_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 518A; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA20793.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D000535 Aluminum D002737 Chloroprene D019327 Copper Sulfate D016912 Levonorgestrel D011794 Quercetin C045651 epigallocatechin gallate C027373 potassium chromate(VI) C010792 testosterone undecanoate C111237 vorinostat

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 10.38 RPKM in Testis Total median expression: 196.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-296.90	908	-0.327	Picture	PostScript	Text
3' UTR	-676.60	2985	-0.227	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q6AHZ1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	LF211320 - JP 2014500723-A/18823: Polycomb-Associated Non-Coding RNAs. CR627437 - Homo sapiens mRNA; cDNA DKFZp781O2147 (from clone DKFZp781O2147). BC109045 - Homo sapiens zinc finger protein 518A, mRNA (cDNA clone MGC:125707 IMAGE:40028941), complete cds. BC109046 - Homo sapiens zinc finger protein 518A, mRNA (cDNA clone MGC:125710 IMAGE:40028950), complete cds. BC030967 - Homo sapiens zinc finger protein 518A, mRNA (cDNA clone IMAGE:4693182), partial cds. MA446897 - JP 2018138019-A/18823: Polycomb-Associated Non-Coding RNAs. AK095317 - Homo sapiens cDNA FLJ37998 fis, clone CTONG2012001. LF345593 - JP 2014500723-A/153096: Polycomb-Associated Non-Coding RNAs. LF345595 - JP 2014500723-A/153098: Polycomb-Associated Non-Coding RNAs. MA581170 - JP 2018138019-A/153096: Polycomb-Associated Non-Coding RNAs. MA581172 - JP 2018138019-A/153098: Polycomb-Associated Non-Coding RNAs. AB002333 - Homo sapiens mRNA for KIAA0335 gene. JD312907 - Sequence 293931 from Patent EP1572962. JD362263 - Sequence 343287 from Patent EP1572962. JD186351 - Sequence 167375 from Patent EP1572962. JD254816 - Sequence 235840 from Patent EP1572962. JD160565 - Sequence 141589 from Patent EP1572962. JD280970 - Sequence 261994 from Patent EP1572962. JD550760 - Sequence 531784 from Patent EP1572962. JD565895 - Sequence 546919 from Patent EP1572962. AB384462 - Synthetic construct DNA, clone: pF1KA0335, Homo sapiens ZNF518 gene for zinc finger protein 518, complete cds, without stop codon, in Flexi system. LF345598 - JP 2014500723-A/153101: Polycomb-Associated Non-Coding RNAs. LF345599 - JP 2014500723-A/153102: Polycomb-Associated Non-Coding RNAs. LF345600 - JP 2014500723-A/153103: Polycomb-Associated Non-Coding RNAs. LF345601 - JP 2014500723-A/153104: Polycomb-Associated Non-Coding RNAs. KJ902030 - Synthetic construct Homo sapiens clone ccsbBroadEn_11424 ZNF518A gene, encodes complete protein. LF345602 - JP 2014500723-A/153105: Polycomb-Associated Non-Coding RNAs. LF345603 - JP 2014500723-A/153106: Polycomb-Associated Non-Coding RNAs. JD482131 - Sequence 463155 from Patent EP1572962. LF345604 - JP 2014500723-A/153107: Polycomb-Associated Non-Coding RNAs. JD245615 - Sequence 226639 from Patent EP1572962. JD047317 - Sequence 28341 from Patent EP1572962. JD420519 - Sequence 401543 from Patent EP1572962. JD359864 - Sequence 340888 from Patent EP1572962. JD196748 - Sequence 177772 from Patent EP1572962. LF345605 - JP 2014500723-A/153108: Polycomb-Associated Non-Coding RNAs. JD538772 - Sequence 519796 from Patent EP1572962. JD434643 - Sequence 415667 from Patent EP1572962. JD303347 - Sequence 284371 from Patent EP1572962. JD327472 - Sequence 308496 from Patent EP1572962. JD313984 - Sequence 295008 from Patent EP1572962. JD479381 - Sequence 460405 from Patent EP1572962. JD120016 - Sequence 101040 from Patent EP1572962. JD521654 - Sequence 502678 from Patent EP1572962. JD214333 - Sequence 195357 from Patent EP1572962. JD495677 - Sequence 476701 from Patent EP1572962. JD284094 - Sequence 265118 from Patent EP1572962. LF345606 - JP 2014500723-A/153109: Polycomb-Associated Non-Coding RNAs. JD449227 - Sequence 430251 from Patent EP1572962. JD067948 - Sequence 48972 from Patent EP1572962. JD368487 - Sequence 349511 from Patent EP1572962. JD419916 - Sequence 400940 from Patent EP1572962. JD052144 - Sequence 33168 from Patent EP1572962. JD363018 - Sequence 344042 from Patent EP1572962. JD359471 - Sequence 340495 from Patent EP1572962. JD175550 - Sequence 156574 from Patent EP1572962. JD456333 - Sequence 437357 from Patent EP1572962. JD149120 - Sequence 130144 from Patent EP1572962. MA581175 - JP 2018138019-A/153101: Polycomb-Associated Non-Coding RNAs. MA581176 - JP 2018138019-A/153102: Polycomb-Associated Non-Coding RNAs. MA581177 - JP 2018138019-A/153103: Polycomb-Associated Non-Coding RNAs. MA581178 - JP 2018138019-A/153104: Polycomb-Associated Non-Coding RNAs. MA581179 - JP 2018138019-A/153105: Polycomb-Associated Non-Coding RNAs. MA581180 - JP 2018138019-A/153106: Polycomb-Associated Non-Coding RNAs. MA581181 - JP 2018138019-A/153107: Polycomb-Associated Non-Coding RNAs. MA581182 - JP 2018138019-A/153108: Polycomb-Associated Non-Coding RNAs. MA581183 - JP 2018138019-A/153109: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: A0PJI5, ENST00000316045.1, ENST00000316045.2, ENST00000316045.3, ENST00000316045.4, ENST00000316045.5, ENST00000316045.6, ENST00000316045.7, ENST00000316045.8, ENST00000316045.9, KIAA0335, NM_001330738, O15044, Q32MP4, Q6AHZ1, uc317pxx.1, uc317pxx.2, Z518A_HUMAN, ZNF518 UCSC ID: ENST00000316045.10_3 RefSeq Accession: NM_001330736.2 Protein: Q6AHZ1 (aka Z518A_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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