Human Gene ZNF512 (ENST00000355467.6_8) from GENCODE V47lift37
  Description: zinc finger protein 512, transcript variant 1 (from RefSeq NM_032434.4)
Gencode Transcript: ENST00000355467.6_8
Gencode Gene: ENSG00000243943.10_13
Transcript (Including UTRs)
   Position: hg19 chr2:27,805,909-27,846,084 Size: 40,176 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr2:27,805,980-27,844,328 Size: 38,349 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:27,805,909-27,846,084)mRNA (may differ from genome)Protein (567 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN512_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 512;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 4 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.86 RPKM in Ovary
Total median expression: 692.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.4071-0.189 Picture PostScript Text
3' UTR -451.601756-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CTD - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q96ME7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK303566 - Homo sapiens cDNA FLJ51176 complete cds, highly similar to Zinc finger protein 512.
BC093041 - Homo sapiens zinc finger protein 512, mRNA (cDNA clone MGC:111046 IMAGE:6173398), complete cds.
AK293771 - Homo sapiens cDNA FLJ52441 complete cds, highly similar to Zinc finger protein 512.
AK316299 - Homo sapiens cDNA, FLJ79198 complete cds, highly similar to Zinc finger protein 512.
BC043221 - Homo sapiens zinc finger protein 512, mRNA (cDNA clone MGC:44297 IMAGE:5295402), complete cds.
AK057028 - Homo sapiens cDNA FLJ32466 fis, clone SKNMC2000065.
BX647996 - Homo sapiens mRNA; cDNA DKFZp686A1559 (from clone DKFZp686A1559).
JD458860 - Sequence 439884 from Patent EP1572962.
AK299818 - Homo sapiens cDNA FLJ53912 complete cds, highly similar to Zinc finger protein 512.
BC015707 - Homo sapiens zinc finger protein 512, mRNA (cDNA clone IMAGE:3910304), containing frame-shift errors.
AK294055 - Homo sapiens cDNA FLJ53832 complete cds, highly similar to Zinc finger protein 512.
AK316011 - Homo sapiens cDNA, FLJ78910 complete cds, highly similar to Zinc finger protein 512.
AB384641 - Synthetic construct DNA, clone: pF1KA1805, Homo sapiens ZNF512 gene for zinc finger protein 512, complete cds, without stop codon, in Flexi system.
AB058708 - Homo sapiens KIAA1805 mRNA for KIAA1805 protein.
CU692148 - Synthetic construct Homo sapiens gateway clone IMAGE:100020917 5' read ZNF512 mRNA.
KJ903426 - Synthetic construct Homo sapiens clone ccsbBroadEn_12820 ZNF512 gene, encodes complete protein.
AL833748 - Homo sapiens mRNA; cDNA DKFZp666L156 (from clone DKFZp666L156).
AK074460 - Homo sapiens cDNA FLJ23880 fis, clone LNG13754.
DL491328 - Novel nucleic acids.
DL489961 - Novel nucleic acids.
JD429166 - Sequence 410190 from Patent EP1572962.
JD299637 - Sequence 280661 from Patent EP1572962.
JD296399 - Sequence 277423 from Patent EP1572962.
JD120439 - Sequence 101463 from Patent EP1572962.
JD293664 - Sequence 274688 from Patent EP1572962.
JD404308 - Sequence 385332 from Patent EP1572962.
JD225977 - Sequence 207001 from Patent EP1572962.
JD345542 - Sequence 326566 from Patent EP1572962.
JD509450 - Sequence 490474 from Patent EP1572962.
JD059004 - Sequence 40028 from Patent EP1572962.
JD270620 - Sequence 251644 from Patent EP1572962.
JD191826 - Sequence 172850 from Patent EP1572962.
JD134490 - Sequence 115514 from Patent EP1572962.
JD564198 - Sequence 545222 from Patent EP1572962.
JD537852 - Sequence 518876 from Patent EP1572962.
JD561897 - Sequence 542921 from Patent EP1572962.
JD253718 - Sequence 234742 from Patent EP1572962.
JD049747 - Sequence 30771 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DSM5, ENST00000355467.1, ENST00000355467.2, ENST00000355467.3, ENST00000355467.4, ENST00000355467.5, KIAA1805, NM_032434, Q53RZ7, Q86XK6, Q96JM0, Q96ME7, uc317zby.1, uc317zby.2, ZN512_HUMAN
UCSC ID: ENST00000355467.6_8
RefSeq Accession: NM_032434.4
Protein: Q96ME7 (aka ZN512_HUMAN or Z512_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.