Human Gene ZMYND19 (ENST00000298585.3_7) from GENCODE V47lift37
  Description: zinc finger MYND-type containing 19 (from RefSeq NM_138462.3)
Gencode Transcript: ENST00000298585.3_7
Gencode Gene: ENSG00000165724.6_9
Transcript (Including UTRs)
   Position: hg19 chr9:140,476,533-140,484,964 Size: 8,432 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr9:140,476,995-140,484,715 Size: 7,721 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:140,476,533-140,484,964)mRNA (may differ from genome)Protein (227 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZMY19_HUMAN
DESCRIPTION: RecName: Full=Zinc finger MYND domain-containing protein 19; AltName: Full=Melanin-concentrating hormone receptor 1-interacting zinc finger protein; Short=MCH-R1-interacting zinc finger protein;
FUNCTION: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.
SUBUNIT: Interacts with GPR24/MCH-R1.
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach.
SIMILARITY: Contains 1 MYND-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016604 Aflatoxin B1
  • C006780 bisphenol A
  • C016403 2,4-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D003300 Copper
  • D003993 Dibutyl Phthalate
  • D005557 Formaldehyde
  • D058185 Magnetite Nanoparticles
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.44 RPKM in Testis
Total median expression: 407.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -157.10249-0.631 Picture PostScript Text
3' UTR -156.90462-0.340 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002893 - Znf_MYND

Pfam Domains:
PF01753 - MYND finger
PF13392 - HNH endonuclease

SCOP Domains:
53955 - Lysozyme-like
54060 - His-Me finger endonucleases
144232 - HIT/MYND zinc finger-like

ModBase Predicted Comparative 3D Structure on Q96E35
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045202 synapse


-  Descriptions from all associated GenBank mRNAs
  AJ298882 - Homo sapiens mRNA for MCH-R interacting zinc-finger protein (MIZIP gene).
AX766496 - Sequence 1 from Patent WO03042242.
BC012948 - Homo sapiens zinc finger, MYND-type containing 19, mRNA (cDNA clone MGC:21390 IMAGE:4519078), complete cds.
JD549700 - Sequence 530724 from Patent EP1572962.
JD330092 - Sequence 311116 from Patent EP1572962.
JD098274 - Sequence 79298 from Patent EP1572962.
JD052054 - Sequence 33078 from Patent EP1572962.
KJ900036 - Synthetic construct Homo sapiens clone ccsbBroadEn_09430 ZMYND19 gene, encodes complete protein.
DQ894648 - Synthetic construct Homo sapiens clone IMAGE:100009108; FLH177200.01L; RZPDo839E06123D zinc finger, MYND-type containing 19 (ZMYND19) gene, encodes complete protein.
DL491752 - Novel nucleic acids.
DQ600495 - Homo sapiens piRNA piR-38561, complete sequence.
JD406106 - Sequence 387130 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000298585.1, ENST00000298585.2, MIZIP, NM_138462, Q5T366, Q96E35, uc317mfh.1, uc317mfh.2, ZMY19_HUMAN
UCSC ID: ENST00000298585.3_7
RefSeq Accession: NM_138462.3
Protein: Q96E35 (aka ZMY19_HUMAN or ZM19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.