Human Gene ZMAT2 (ENST00000274712.8_4) from GENCODE V47lift37

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Description: zinc finger matrin-type 2 (from RefSeq NM_144723.3)
Gencode Transcript: ENST00000274712.8_4
Gencode Gene: ENSG00000146007.11_10
Transcript (Including UTRs)
Position: hg19 chr5:140,080,032-140,086,271 Size: 6,240 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr5:140,080,046-140,085,341 Size: 5,296 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:140,080,032-140,086,271)			mRNA (may differ from genome)		Protein (199 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZMAT2_HUMAN DESCRIPTION: RecName: Full=Zinc finger matrin-type protein 2; SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Contains 1 matrin-type zinc finger.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ZMAT2 Diseases sorted by gene-association score: chondrosarcoma, extraskeletal myxoid (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 66.72 RPKM in Brain - Nucleus accumbens (basal ganglia) Total median expression: 2137.37 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-272.30	930	-0.293	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR015880 - Znf_C2H2-like
IPR022755 - Znf_C2H2_jaz
IPR003604 - Znf_U1

Pfam Domains:
PF12171 - Zinc-finger double-stranded RNA-binding
PF12874 - Zinc-finger of C2H2 type

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q96NC0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003723 RNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0046872 metal ion binding Biological Process: GO:0000398 mRNA splicing, via spliceosome Cellular Component: GO:0005634 nucleus GO:0046540 U4/U6 x U5 tri-snRNP complex

Descriptions from all associated GenBank mRNAs


	BC056668 - Homo sapiens zinc finger, matrin type 2, mRNA (cDNA clone MGC:61999 IMAGE:4773709), complete cds. AK055683 - Homo sapiens cDNA FLJ31121 fis, clone IMR322000742, weakly similar to HYPOTHETICAL ZINC FINGER PROTEIN ZK686.4 IN CHROMOSOME III. KJ895679 - Synthetic construct Homo sapiens clone ccsbBroadEn_05073 ZMAT2 gene, encodes complete protein. HQ447705 - Synthetic construct Homo sapiens clone IMAGE:100071033; CCSB013326_01 zinc finger, matrin type 2 (ZMAT2) gene, encodes complete protein. X97303 - H.sapiens mRNA for Ptg-12 protein. JD347904 - Sequence 328928 from Patent EP1572962. JD343538 - Sequence 324562 from Patent EP1572962. JD482892 - Sequence 463916 from Patent EP1572962. JD433636 - Sequence 414660 from Patent EP1572962. JD324668 - Sequence 305692 from Patent EP1572962. JD086516 - Sequence 67540 from Patent EP1572962. JD291981 - Sequence 273005 from Patent EP1572962. JD104841 - Sequence 85865 from Patent EP1572962. JD281878 - Sequence 262902 from Patent EP1572962. JD524194 - Sequence 505218 from Patent EP1572962. JD283936 - Sequence 264960 from Patent EP1572962. JD283877 - Sequence 264901 from Patent EP1572962. JD290478 - Sequence 271502 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000274712.1, ENST00000274712.2, ENST00000274712.3, ENST00000274712.4, ENST00000274712.5, ENST00000274712.6, ENST00000274712.7, NM_144723, Q96NC0, uc317jge.1, uc317jge.2, ZMAT2_HUMAN UCSC ID: ENST00000274712.8_4 RefSeq Accession: NM_144723.3 Protein: Q96NC0 (aka ZMAT2_HUMAN or ZMA2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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