ID:ZFP91_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase ZFP91; EC=6.3.2.-; AltName: Full=Zinc finger protein 757; AltName: Full=Zinc finger protein 91 homolog; Short=Zfp-91; FUNCTION: Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with MAP3K14/NIK. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific. MISCELLANEOUS: In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAL09963.1; Type=Frameshift; Positions=72, 80;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96JP5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0004842 ubiquitin-protein transferase activity GO:0016740 transferase activity GO:0046872 metal ion binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0016567 protein ubiquitination GO:0070534 protein K63-linked ubiquitination
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
