Human Gene ZFP36 (ENST00000597629.3_9) from GENCODE V47lift37
  Description: ZFP36 ring finger protein (from RefSeq NM_003407.5)
Gencode Transcript: ENST00000597629.3_9
Gencode Gene: ENSG00000128016.8_15
Transcript (Including UTRs)
   Position: hg19 chr19:39,897,487-39,900,047 Size: 2,561 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr19:39,897,545-39,899,339 Size: 1,795 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:39,897,487-39,900,047)mRNA (may differ from genome)Protein (326 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
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-  Comments and Description Text from UniProtKB
  ID: TTP_HUMAN
DESCRIPTION: RecName: Full=Tristetraprolin; Short=TTP; AltName: Full=G0/G1 switch regulatory protein 24; AltName: Full=Growth factor-inducible nuclear protein NUP475; AltName: Full=Protein TIS11A; Short=TIS11; AltName: Full=Zinc finger protein 36 homolog; Short=Zfp-36;
FUNCTION: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
INTERACTION: Q9NPI6:DCP1A; NbExp=2; IntAct=EBI-374248, EBI-374238; Q96F86:EDC3; NbExp=2; IntAct=EBI-374248, EBI-997311;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
INDUCTION: By stimulation with various mitogens.
PTM: Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
SIMILARITY: Contains 2 C3H1-type zinc fingers.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/zfp36/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 751.07 RPKM in Adipose - Visceral (Omentum)
Total median expression: 9445.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.0058-0.190 Picture PostScript Text
3' UTR -200.50708-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000571 - Znf_CCCH

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PF14608 - RNA-binding, Nab2-type zinc finger

SCOP Domains:
90229 - CCCH zinc finger

ModBase Predicted Comparative 3D Structure on P26651
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0017091 AU-rich element binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019957 C-C chemokine binding
GO:0031072 heat shock protein binding
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0046872 metal ion binding
GO:0070063 RNA polymerase binding
GO:0071889 14-3-3 protein binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402 mRNA catabolic process
GO:0009611 response to wounding
GO:0010837 regulation of keratinocyte proliferation
GO:0031047 gene silencing by RNA
GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
GO:0032680 regulation of tumor necrosis factor production
GO:0032897 negative regulation of viral transcription
GO:0035278 miRNA mediated inhibition of translation
GO:0038066 p38MAPK cascade
GO:0042594 response to starvation
GO:0043488 regulation of mRNA stability
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0051028 mRNA transport
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0061158 3'-UTR-mediated mRNA destabilization
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:1901835 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
GO:1902172 regulation of keratinocyte apoptotic process
GO:1904246 negative regulation of polynucleotide adenylyltransferase activity
GO:1904582 positive regulation of intracellular mRNA localization
GO:2000637 positive regulation of gene silencing by miRNA

Cellular Component:
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:1990904 ribonucleoprotein complex
GO:0030014 CCR4-NOT complex
GO:0070578 RISC-loading complex
GO:0098745 Dcp1-Dcp2 complex
GO:0000178 exosome (RNase complex)


-  Descriptions from all associated GenBank mRNAs
  AK314042 - Homo sapiens cDNA, FLJ94702, Homo sapiens zinc finger protein 36, C3H type, homolog (mouse)(ZFP36), mRNA.
M92843 - H.sapiens zinc finger transcriptional regulator mRNA, complete cds.
BC009693 - Homo sapiens zinc finger protein 36, C3H type, homolog (mouse), mRNA (cDNA clone MGC:9162 IMAGE:3900312), complete cds.
M63625 - Human tristetraproline (TTP) mRNA, complete cds.
EU446714 - Synthetic construct Homo sapiens clone IMAGE:100070206; IMAGE:100011923; FLH257325.01L zinc finger protein 36, C3H type, homolog (mouse) (ZFP36) gene, encodes complete protein.
EU832272 - Synthetic construct Homo sapiens clone HAIB:100067301; DKFZo004H1026 zinc finger protein 36, C3H type, homolog (mouse) protein (ZFP36) gene, encodes complete protein.
EU832179 - Synthetic construct Homo sapiens clone HAIB:100067208; DKFZo008H1025 zinc finger protein 36, C3H type, homolog (mouse) protein (ZFP36) gene, encodes complete protein.
CU679443 - Synthetic construct Homo sapiens gateway clone IMAGE:100018952 5' read ZFP36 mRNA.
KJ897749 - Synthetic construct Homo sapiens clone ccsbBroadEn_07143 ZFP36 gene, encodes complete protein.
JD546021 - Sequence 527045 from Patent EP1572962.
JD439559 - Sequence 420583 from Patent EP1572962.
JD283064 - Sequence 264088 from Patent EP1572962.
JD149788 - Sequence 130812 from Patent EP1572962.
JD554285 - Sequence 535309 from Patent EP1572962.
JD486162 - Sequence 467186 from Patent EP1572962.
JD418579 - Sequence 399603 from Patent EP1572962.
JD214757 - Sequence 195781 from Patent EP1572962.
AJ227917 - Homo sapiens partial mRNA; ID EE2-12C.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P26651 (Reactome details) participates in the following event(s):

R-HSA-450400 ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs
R-HSA-450394 p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta
R-HSA-450463 MK2 phosphorylates ZFP36 (Tristetraproline, TTP)
R-HSA-450431 ZFP36 (TTP) recruits RNA degradation activities
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: B2RA54, ENST00000597629.1, ENST00000597629.2, G0S24, NM_003407, NUP475 , P26651, RNF162A, TIS11A, TTP , TTP_HUMAN, uc327cke.1, uc327cke.2, ZFP36
UCSC ID: ENST00000597629.3_9
RefSeq Accession: NM_003407.5
Protein: P26651 (aka TTP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.