Human Gene ZFP30 (ENST00000684514.1_3) from GENCODE V47lift37

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Description: ZFP30 zinc finger protein, transcript variant 7 (from RefSeq NM_001320671.3)
Gencode Transcript: ENST00000684514.1_3
Gencode Gene: ENSG00000120784.17_16
Transcript (Including UTRs)
Position: hg19 chr19:38,121,907-38,146,366 Size: 24,460 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr19:38,125,882-38,138,723 Size: 12,842 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:38,121,907-38,146,366)			mRNA (may differ from genome)		Protein (519 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZFP30_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 30 homolog; Short=Zfp-30; AltName: Full=Zinc finger protein 745; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 13 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain. SEQUENCE CAUTION: Sequence=BAA76805.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ZFP30 Diseases sorted by gene-association score: cerebral visual impairment (8)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane C027576 4-hydroxy-2-nonenal D002794 Choline D005492 Folic Acid D005557 Formaldehyde D008715 Methionine D009538 Nicotine D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C034028 vanadyl sulfate

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-94.70	291	-0.325	Picture	PostScript	Text
3' UTR	-1207.20	3975	-0.304	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q9Y2G7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	BC041087 - Homo sapiens zinc finger protein 30 homolog (mouse), mRNA (cDNA clone MGC:45116 IMAGE:5579247), complete cds. BC050542 - Homo sapiens zinc finger protein 30 homolog (mouse), mRNA (cDNA clone IMAGE:6052284). AB023178 - Homo sapiens KIAA0961 mRNA for KIAA0961 protein. LF384241 - JP 2014500723-A/191744: Polycomb-Associated Non-Coding RNAs. GU388430 - Homo sapiens zinc finger protein 30 (ZFP30) mRNA, complete cds. AK297301 - Homo sapiens cDNA FLJ60691 complete cds, moderately similar to Zinc finger protein 30. MA619818 - JP 2018138019-A/191744: Polycomb-Associated Non-Coding RNAs. JD312578 - Sequence 293602 from Patent EP1572962. JD531975 - Sequence 512999 from Patent EP1572962. JD364123 - Sequence 345147 from Patent EP1572962. JD248174 - Sequence 229198 from Patent EP1572962. JD120050 - Sequence 101074 from Patent EP1572962. JD180965 - Sequence 161989 from Patent EP1572962. JD196433 - Sequence 177457 from Patent EP1572962. JD523083 - Sequence 504107 from Patent EP1572962. JD166976 - Sequence 148000 from Patent EP1572962. JD154446 - Sequence 135470 from Patent EP1572962. JD198843 - Sequence 179867 from Patent EP1572962. JD388957 - Sequence 369981 from Patent EP1572962. JD293448 - Sequence 274472 from Patent EP1572962. JD457527 - Sequence 438551 from Patent EP1572962. JD457528 - Sequence 438552 from Patent EP1572962. JD227648 - Sequence 208672 from Patent EP1572962. JD523082 - Sequence 504106 from Patent EP1572962. JD457526 - Sequence 438550 from Patent EP1572962. JD405628 - Sequence 386652 from Patent EP1572962. JD547670 - Sequence 528694 from Patent EP1572962. JD547669 - Sequence 528693 from Patent EP1572962. JD106632 - Sequence 87656 from Patent EP1572962. JD047678 - Sequence 28702 from Patent EP1572962. JD135838 - Sequence 116862 from Patent EP1572962. JD354436 - Sequence 335460 from Patent EP1572962. JD439278 - Sequence 420302 from Patent EP1572962. JD112142 - Sequence 93166 from Patent EP1572962. JD420280 - Sequence 401304 from Patent EP1572962. JD112141 - Sequence 93165 from Patent EP1572962. JD383844 - Sequence 364868 from Patent EP1572962. JD420279 - Sequence 401303 from Patent EP1572962. JD558269 - Sequence 539293 from Patent EP1572962. JD564336 - Sequence 545360 from Patent EP1572962. JD070835 - Sequence 51859 from Patent EP1572962. JD319335 - Sequence 300359 from Patent EP1572962. JD319334 - Sequence 300358 from Patent EP1572962. JD179843 - Sequence 160867 from Patent EP1572962. JD067978 - Sequence 49002 from Patent EP1572962. JD481483 - Sequence 462507 from Patent EP1572962. JD284146 - Sequence 265170 from Patent EP1572962. JD433715 - Sequence 414739 from Patent EP1572962. JD232304 - Sequence 213328 from Patent EP1572962. JD504379 - Sequence 485403 from Patent EP1572962. JD081687 - Sequence 62711 from Patent EP1572962. JD501157 - Sequence 482181 from Patent EP1572962. JD226016 - Sequence 207040 from Patent EP1572962. JD566787 - Sequence 547811 from Patent EP1572962. JD349225 - Sequence 330249 from Patent EP1572962. AB384061 - Synthetic construct DNA, clone: pF1KSDA0961, Homo sapiens ZFP30 gene for zinc finger protein 30 homolog, complete cds, without stop codon, in Flexi system. EU446777 - Synthetic construct Homo sapiens clone IMAGE:100069934; IMAGE:100011986; FLH257141.01L zinc finger protein 30 homolog (mouse) (ZFP30) gene, encodes complete protein. JD032199 - Sequence 13223 from Patent EP1572962. JD314886 - Sequence 295910 from Patent EP1572962. JD314887 - Sequence 295911 from Patent EP1572962. JD246154 - Sequence 227178 from Patent EP1572962. LF367307 - JP 2014500723-A/174810: Polycomb-Associated Non-Coding RNAs. JD470608 - Sequence 451632 from Patent EP1572962. JD223616 - Sequence 204640 from Patent EP1572962. MA602884 - JP 2018138019-A/174810: Polycomb-Associated Non-Coding RNAs. JD336239 - Sequence 317263 from Patent EP1572962. JD537098 - Sequence 518122 from Patent EP1572962. JD310417 - Sequence 291441 from Patent EP1572962. JD220948 - Sequence 201972 from Patent EP1572962. JD043869 - Sequence 24893 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9Y2G7 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: KIAA0961, NM_001320671, Q58EY8, Q9Y2G7, uc330mzi.1, uc330mzi.2, ZFP30_HUMAN, ZNF745 UCSC ID: ENST00000684514.1_3 RefSeq Accession: NM_001320669.3 Protein: Q9Y2G7 (aka ZFP30_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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