Human Gene ZDHHC5 (ENST00000287169.8_4) from GENCODE V47lift37

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Description: zinc finger DHHC-type palmitoyltransferase 5 (from RefSeq NM_015457.3)
Gencode Transcript: ENST00000287169.8_4
Gencode Gene: ENSG00000156599.11_10
Transcript (Including UTRs)
Position: hg19 chr11:57,435,586-57,468,654 Size: 33,069 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr11:57,440,563-57,467,503 Size: 26,941 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:57,435,586-57,468,654)			mRNA (may differ from genome)		Protein (715 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZDHC5_HUMAN DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC5; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 5; Short=DHHC-5; AltName: Full=Zinc finger protein 375; FUNCTION: Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity). CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity). SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. SIMILARITY: Contains 1 DHHC-type zinc finger. SEQUENCE CAUTION: Sequence=BAB21839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD18778.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D002794 Choline D002922 Ciguatoxins D003993 Dibutyl Phthalate D004147 Dioxins D004997 Ethinyl Estradiol D005492 Folic Acid D008715 Methionine D012999 Soman more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 38.73 RPKM in Esophagus - Mucosa Total median expression: 809.42 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-365.10	1144	-0.319	Picture	PostScript	Text
3' UTR	-380.90	1151	-0.331	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q9C0B5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0016409 palmitoyltransferase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0019706 protein-cysteine S-palmitoyltransferase activity Biological Process: GO:0018345 protein palmitoylation Cellular Component: GO:0005737 cytoplasm GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0030425 dendrite

Descriptions from all associated GenBank mRNAs


	AY894889 - Homo sapiens membrane-associated DHHC5 zinc finger protein mRNA, complete cds. AB051535 - Homo sapiens KIAA1748 mRNA for KIAA1748 protein. BC026967 - Homo sapiens zinc finger, DHHC-type containing 5, mRNA (cDNA clone MGC:34718 IMAGE:3913317), complete cds. JD260770 - Sequence 241794 from Patent EP1572962. JD422526 - Sequence 403550 from Patent EP1572962. JD062256 - Sequence 43280 from Patent EP1572962. JD305706 - Sequence 286730 from Patent EP1572962. JD282975 - Sequence 263999 from Patent EP1572962. JD172535 - Sequence 153559 from Patent EP1572962. JD037989 - Sequence 19013 from Patent EP1572962. AK023130 - Homo sapiens cDNA FLJ13068 fis, clone NT2RP3001739, weakly similar to HYPOTHETICAL 72.5 KD PROTEIN C2F7.10 IN CHROMOSOME I. JD173047 - Sequence 154071 from Patent EP1572962. JD385919 - Sequence 366943 from Patent EP1572962. JD317523 - Sequence 298547 from Patent EP1572962. JD549297 - Sequence 530321 from Patent EP1572962. JD539469 - Sequence 520493 from Patent EP1572962. JD428641 - Sequence 409665 from Patent EP1572962. JD550462 - Sequence 531486 from Patent EP1572962. JD262418 - Sequence 243442 from Patent EP1572962. JD422413 - Sequence 403437 from Patent EP1572962. JD467472 - Sequence 448496 from Patent EP1572962. AB384284 - Synthetic construct DNA, clone: pF1KSDA1748, Homo sapiens ZDHHC5 gene for palmitoyltransferase ZDHHC5, complete cds, without stop codon, in Flexi system. BX647707 - Homo sapiens mRNA; cDNA DKFZp686A1286 (from clone DKFZp686A1286). CU693244 - Synthetic construct Homo sapiens gateway clone IMAGE:100019987 5' read ZDHHC5 mRNA. DQ892450 - Synthetic construct clone IMAGE:100005080; FLH186441.01X; RZPDo839E0771D zinc finger, DHHC-type containing 5 (ZDHHC5) gene, encodes complete protein. DQ895662 - Synthetic construct Homo sapiens clone IMAGE:100010122; FLH186437.01L; RZPDo839E0761D zinc finger, DHHC-type containing 5 (ZDHHC5) gene, encodes complete protein. KJ902390 - Synthetic construct Homo sapiens clone ccsbBroadEn_11784 ZDHHC5 gene, encodes complete protein. AK172807 - Homo sapiens cDNA FLJ23968 fis, clone HEP16755. AL117662 - Homo sapiens mRNA; cDNA DKFZp586K0524 (from clone DKFZp586K0524); partial cds. JD256421 - Sequence 237445 from Patent EP1572962. JD210223 - Sequence 191247 from Patent EP1572962. JD384668 - Sequence 365692 from Patent EP1572962. JD323465 - Sequence 304489 from Patent EP1572962. JD146868 - Sequence 127892 from Patent EP1572962. JD252845 - Sequence 233869 from Patent EP1572962. JD491764 - Sequence 472788 from Patent EP1572962. JD060868 - Sequence 41892 from Patent EP1572962. JD560307 - Sequence 541331 from Patent EP1572962. JD380978 - Sequence 362002 from Patent EP1572962. JD455232 - Sequence 436256 from Patent EP1572962. JD359874 - Sequence 340898 from Patent EP1572962. JD038311 - Sequence 19335 from Patent EP1572962. JD110942 - Sequence 91966 from Patent EP1572962. JD307556 - Sequence 288580 from Patent EP1572962. JD398193 - Sequence 379217 from Patent EP1572962. JD183361 - Sequence 164385 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000287169.1, ENST00000287169.2, ENST00000287169.3, ENST00000287169.4, ENST00000287169.5, ENST00000287169.6, ENST00000287169.7, KIAA1748, NM_015457, Q2TGF0, Q6ZMF0, Q8TAK8, Q9C0B5, Q9H923, Q9UFI7, uc317kmd.1, uc317kmd.2, ZDHC5_HUMAN, ZNF375 UCSC ID: ENST00000287169.8_4 RefSeq Accession: NM_015457.3 Protein: Q9C0B5 (aka ZDHC5_HUMAN or ZDH5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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