Human Gene ZC3H14 (ENST00000251038.10_11) from GENCODE V47lift37

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Description: zinc finger CCCH-type containing 14, transcript variant 29 (from RefSeq NR_136936.2)
Gencode Transcript: ENST00000251038.10_11
Gencode Gene: ENSG00000100722.20_20
Transcript (Including UTRs)
Position: hg19 chr14:89,029,381-89,093,940 Size: 64,560 Total Exon Count: 17 Strand: +
Coding Region
Position: hg19 chr14:89,029,478-89,078,095 Size: 48,618 Coding Exon Count: 17

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:89,029,381-89,093,940)			mRNA (may differ from genome)		Protein (736 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZC3HE_HUMAN DESCRIPTION: RecName: Full=Zinc finger CCCH domain-containing protein 14; AltName: Full=Mammalian suppressor of tau pathology-2; Short=MSUT-2; AltName: Full=Renal carcinoma antigen NY-REN-37; FUNCTION: Binds the polyadenosine RNA oligonucleotides. SUBUNIT: Interacts with HOOK2. SUBCELLULAR LOCATION: Nucleus speckle. SUBCELLULAR LOCATION: Isoform 1: Nucleus speckle. SUBCELLULAR LOCATION: Isoform 3: Nucleus speckle. SUBCELLULAR LOCATION: Isoform 6: Cytoplasm. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the ZC3H14 family. SIMILARITY: Contains 5 C3H1-type zinc fingers. SEQUENCE CAUTION: Sequence=AAL83289.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors; Sequence=AAS90302.1; Type=Frameshift; Positions=Several; Sequence=AAS90302.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AK021868; Type=Frameshift; Positions=199; Sequence=CAE45933.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ZC3H14 Diseases sorted by gene-association score: mental retardation, autosomal recessive 56* (1019), autosomal recessive non-syndromic intellectual disability* (58) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene D002737 Chloroprene D003993 Dibutyl Phthalate D004026 Dieldrin D004147 Dioxins D004997 Ethinyl Estradiol D008627 Mercuric Chloride D012822 Silicon Dioxide D013629 Tamoxifen more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 58.14 RPKM in Testis Total median expression: 462.66 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-43.90	97	-0.453	Picture	PostScript	Text
3' UTR	-4559.40	15845	-0.288	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000571 - Znf_CCCH

Pfam Domains:
PF14608 - RNA-binding, Nab2-type zinc finger

ModBase Predicted Comparative 3D Structure on Q6PJT7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding GO:0008143 poly(A) binding GO:0046872 metal ion binding Biological Process: GO:0043488 regulation of mRNA stability GO:1900364 negative regulation of mRNA polyadenylation Cellular Component: GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0016607 nuclear speck GO:0032839 dendrite cytoplasm GO:1904115 axon cytoplasm GO:1990904 ribonucleoprotein complex

Descriptions from all associated GenBank mRNAs


	LF384877 - JP 2014500723-A/192380: Polycomb-Associated Non-Coding RNAs. MA620454 - JP 2018138019-A/192380: Polycomb-Associated Non-Coding RNAs. AY578061 - Homo sapiens putative NY-REN-37 antigen isoform 2 mRNA, complete cds, alternatively spliced. AK302136 - Homo sapiens cDNA FLJ53396 complete cds, highly similar to Homo sapiens nuclear protein UKp68, transcript variant 2, mRNA. AK303123 - Homo sapiens cDNA FLJ54768 complete cds, highly similar to Homo sapiens nuclear protein UKp68, transcript variant 2, mRNA. AY578060 - Homo sapiens putative NY-REN-37 antigen isoform 1 mRNA, complete cds, alternatively spliced. BX640716 - Homo sapiens mRNA; cDNA DKFZp686G07192 (from clone DKFZp686G07192). AK304275 - Homo sapiens cDNA FLJ56206 complete cds, highly similar to Homo sapiens nuclear protein UKp68, transcript variant 1, mRNA. BC011793 - Homo sapiens zinc finger CCCH-type containing 14, mRNA (cDNA clone MGC:19476 IMAGE:4298961), complete cds. AK021868 - Homo sapiens cDNA FLJ11806 fis, clone HEMBA1006283. JD100509 - Sequence 81533 from Patent EP1572962. AL834215 - Homo sapiens mRNA; cDNA DKFZp434D1620 (from clone DKFZp434D1620). AY578062 - Homo sapiens putative NY-REN-37 antigen isoform 3 mRNA, complete cds, alternatively spliced. LF211689 - JP 2014500723-A/19192: Polycomb-Associated Non-Coding RNAs. JD357311 - Sequence 338335 from Patent EP1572962. JD523949 - Sequence 504973 from Patent EP1572962. LF209512 - JP 2014500723-A/17015: Polycomb-Associated Non-Coding RNAs. BX248265 - human full-length cDNA clone CS0DC004YJ14 of Neuroblastoma of Homo sapiens (human). JD040491 - Sequence 21515 from Patent EP1572962. BC023641 - Homo sapiens zinc finger CCCH-type containing 14, mRNA (cDNA clone IMAGE:4904207), partial cds. JD315545 - Sequence 296569 from Patent EP1572962. JD515777 - Sequence 496801 from Patent EP1572962. JD332684 - Sequence 313708 from Patent EP1572962. JD310856 - Sequence 291880 from Patent EP1572962. JD229947 - Sequence 210971 from Patent EP1572962. JD491596 - Sequence 472620 from Patent EP1572962. LF329188 - JP 2014500723-A/136691: Polycomb-Associated Non-Coding RNAs. LF329189 - JP 2014500723-A/136692: Polycomb-Associated Non-Coding RNAs. AY578063 - Homo sapiens putative NY-REN-37 antigen isoform 4 mRNA, complete cds, alternatively spliced. BX248281 - human full-length cDNA clone CS0DI025YA24 of Placenta of Homo sapiens (human). BC027607 - Homo sapiens zinc finger CCCH-type containing 14, mRNA (cDNA clone IMAGE:4828241), complete cds. AF474376 - Homo sapiens putative NY-REN-37 antigen mRNA, complete cds. EU832484 - Synthetic construct Homo sapiens clone HAIB:100067513; DKFZo008E0129 zinc finger CCCH-type containing 14 protein (ZC3H14) gene, encodes complete protein. EU832564 - Synthetic construct Homo sapiens clone HAIB:100067593; DKFZo004E0130 zinc finger CCCH-type containing 14 protein (ZC3H14) gene, encodes complete protein. KJ894751 - Synthetic construct Homo sapiens clone ccsbBroadEn_04145 ZC3H14 gene, encodes complete protein. BX640876 - Homo sapiens mRNA; cDNA DKFZp779C2244 (from clone DKFZp779C2244). AF155107 - Homo sapiens NY-REN-37 antigen mRNA, partial cds. AK090809 - Homo sapiens cDNA FLJ33490 fis, clone BRAMY2003634. BX248769 - human full-length cDNA 3-PRIME end of clone CS0DI015YF10 of Placenta of Homo sapiens (human). JD400807 - Sequence 381831 from Patent EP1572962. AL359625 - Homo sapiens mRNA; cDNA DKFZp762G207 (from clone DKFZp762G207). BC034274 - Homo sapiens nuclear protein UKp68, mRNA (cDNA clone IMAGE:4707202), partial cds. JD564324 - Sequence 545348 from Patent EP1572962. JD329066 - Sequence 310090 from Patent EP1572962. JD321292 - Sequence 302316 from Patent EP1572962. JD567067 - Sequence 548091 from Patent EP1572962. JD337633 - Sequence 318657 from Patent EP1572962. JD463148 - Sequence 444172 from Patent EP1572962. AK054679 - Homo sapiens cDNA FLJ30117 fis, clone BRACE1000047. JD308190 - Sequence 289214 from Patent EP1572962. JD150738 - Sequence 131762 from Patent EP1572962. JD432341 - Sequence 413365 from Patent EP1572962. JD416486 - Sequence 397510 from Patent EP1572962. JD543196 - Sequence 524220 from Patent EP1572962. JD478512 - Sequence 459536 from Patent EP1572962. JD463757 - Sequence 444781 from Patent EP1572962. JD148244 - Sequence 129268 from Patent EP1572962. JD249739 - Sequence 230763 from Patent EP1572962. JD378204 - Sequence 359228 from Patent EP1572962. MA564765 - JP 2018138019-A/136691: Polycomb-Associated Non-Coding RNAs. MA564766 - JP 2018138019-A/136692: Polycomb-Associated Non-Coding RNAs. MA447266 - JP 2018138019-A/19192: Polycomb-Associated Non-Coding RNAs. MA445089 - JP 2018138019-A/17015: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: A8MY46, B4DXU8, B4DZW7, B4E2H4, ENST00000251038.1, ENST00000251038.2, ENST00000251038.3, ENST00000251038.4, ENST00000251038.5, ENST00000251038.6, ENST00000251038.7, ENST00000251038.8, ENST00000251038.9, G3V5R4, NR_136936, Q6MZU4, Q6PJ32, Q6PJT7, Q6PUI6, Q6PUI8, Q86TQ5, Q86TW0, Q86TW1, Q8NCT6, Q8NCZ3, Q8TDE2, Q9HAC9, Q9Y5A0, uc317fct.1, uc317fct.2, ZC3HE_HUMAN UCSC ID: ENST00000251038.10_11 RefSeq Accession: NM_024824.5 Protein: Q6PJT7 (aka ZC3HE_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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