Human Gene ZBTB20 (ENST00000675478.1_6) from GENCODE V47lift37

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Description: zinc finger and BTB domain containing 20, transcript variant 10 (from RefSeq NM_001348803.3)
Gencode Transcript: ENST00000675478.1_6
Gencode Gene: ENSG00000181722.18_17
Transcript (Including UTRs)
Position: hg19 chr3:114,033,347-114,866,135 Size: 832,789 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr3:114,057,852-114,099,634 Size: 41,783 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:114,033,347-114,866,135)			mRNA (may differ from genome)		Protein (741 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZBT20_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 20; AltName: Full=Dendritic-derived BTB/POZ zinc finger protein; AltName: Full=Zinc finger protein 288; FUNCTION: May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. SUBUNIT: Can homodimerize. Binds to DNA. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 5 C2H2-type zinc fingers.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ZBTB20 Diseases sorted by gene-association score: primrose syndrome* (1599), juvenile pilocytic astrocytoma (7) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D016604 Aflatoxin B1 D003993 Dibutyl Phthalate D013749 Tetrachlorodibenzodioxin C023514 2,6-dinitrotoluene C027576 4-hydroxy-2-nonenal D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D015127 9,10-Dimethyl-1,2-benzanthracene D000393 Air Pollutants D001104 Arbutin more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-194.60	772	-0.252	Picture	PostScript	Text
3' UTR	-6328.42	24505	-0.258	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
54695 - POZ domain
57667 - beta-beta-alpha zinc fingers
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on Q9HC78


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0010629 negative regulation of gene expression GO:0032728 positive regulation of interferon-beta production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0045892 negative regulation of transcription, DNA-templated Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0016604 nuclear body

Descriptions from all associated GenBank mRNAs


	BC090936 - Homo sapiens zinc finger and BTB domain containing 20, mRNA (cDNA clone IMAGE:3102507). BC029041 - Homo sapiens zinc finger and BTB domain containing 20, mRNA (cDNA clone MGC:34359 IMAGE:5184140), complete cds. AK225788 - Homo sapiens mRNA for Zinc finger and BTB domain containing protein 20 variant, clone: FCC131F01. BX647778 - Homo sapiens mRNA; cDNA DKFZp686O0759 (from clone DKFZp686O0759). AL050276 - Homo sapiens mRNA; cDNA DKFZp566F123 (from clone DKFZp566F123). AK315307 - Homo sapiens cDNA, FLJ96336, highly similar to Homo sapiens zinc finger and BTB domain containing 20 (ZBTB20),mRNA. BC010934 - Homo sapiens zinc finger and BTB domain containing 20, mRNA (cDNA clone IMAGE:4291354), partial cds. BX648237 - Homo sapiens mRNA; cDNA DKFZp686E07108 (from clone DKFZp686E07108). AL049423 - Homo sapiens mRNA; cDNA DKFZp586B211 (from clone DKFZp586B211). BC035518 - Homo sapiens, clone IMAGE:4214654, mRNA. BC016962 - Homo sapiens, clone IMAGE:4182947, mRNA. HZ408647 - JP 2015528002-A/1244: CHIRAL CONTROL. LG051981 - KR 1020150036642-A/1247: CHIRAL CONTROL. FW312328 - DETECTING NUCLEIC ACIDS. FW364469 - Oligonucleotides for modulating target RNA activity. HI964911 - Sequence 196 from Patent WO2010139812. HI965856 - Sequence 176 from Patent WO2010139811. HI966722 - Sequence 176 from Patent WO2010139810. HV595381 - JP 2010539959-A/762: Micromirs. HZ074411 - JP 2013535982-A/502: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer. HZ157938 - JP 2015130862-A/762: Micromirs. HZ186782 - JP 2015146814-A/531: Oligonucleotides for modulating target RNA activity. HZ482323 - JP 2015535430-A/2829: TERMINALLY MODIFIED RNA. HZ792254 - JP 2016504050-A/3999: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JA400949 - Sequence 196 from Patent WO2011080318. JA401927 - Sequence 196 from Patent WO2011080315. JA402934 - Sequence 196 from Patent WO2011080316. JA405565 - Sequence 196 from Patent EP2336353. JA429091 - Sequence 196 from Patent WO2011095623. JA660716 - Sequence 170 from Patent WO2011131354. JA757941 - Sequence 74 from Patent WO2012010584. JA791877 - Sequence 279 from Patent WO2012089772. JA792017 - Sequence 66 from Patent WO2012089753. JB022434 - Sequence 276 from Patent WO2013026685. JB022838 - Sequence 92 from Patent WO2013026684. JB620596 - Sequence 576 from Patent WO2013063544. JB733763 - Sequence 3166 from Patent WO2013082448. JC514986 - Sequence 5239 from Patent WO2014113089. JE978725 - Sequence 170 from Patent EP2865765. LF161557 - JP 2016513950-A/1623: Oligomers with improved off-target profile. LP726482 - Sequence 176 from Patent EP2883966. LP818752 - Sequence 176 from Patent EP3296406. LP938694 - Sequence 176 from Patent EP3184651. LQ072574 - Sequence 2898 from Patent EP2964234. LY405446 - KR 1020160117535-A/751: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES. LZ234139 - JP 2017184756-A/531: Oligonucleotides for modulating target RNA activity. MA260685 - JP 2017505623-A/751: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES. MS673289 - Sequence 92 from Patent EP3135774. MS834050 - Sequence 196 from Patent EP3112479. MS901803 - Sequence 276 from Patent EP3156505. AK001020 - Homo sapiens cDNA FLJ10158 fis, clone HEMBA1003463. AK091904 - Homo sapiens cDNA FLJ34585 fis, clone KIDNE2008758. JD024737 - Sequence 5761 from Patent EP1572962. JD028653 - Sequence 9677 from Patent EP1572962. JD032719 - Sequence 13743 from Patent EP1572962. AK022228 - Homo sapiens cDNA FLJ12166 fis, clone MAMMA1000616. JD362600 - Sequence 343624 from Patent EP1572962. JD305434 - Sequence 286458 from Patent EP1572962. JD266399 - Sequence 247423 from Patent EP1572962. JD036652 - Sequence 17676 from Patent EP1572962. JD155398 - Sequence 136422 from Patent EP1572962. JD101093 - Sequence 82117 from Patent EP1572962. JD285193 - Sequence 266217 from Patent EP1572962. JD040329 - Sequence 21353 from Patent EP1572962. JD042599 - Sequence 23623 from Patent EP1572962. JD058836 - Sequence 39860 from Patent EP1572962. JD502311 - Sequence 483335 from Patent EP1572962. JD509493 - Sequence 490517 from Patent EP1572962. JD184399 - Sequence 165423 from Patent EP1572962. JD119972 - Sequence 100996 from Patent EP1572962. JD262635 - Sequence 243659 from Patent EP1572962. JD088627 - Sequence 69651 from Patent EP1572962. AK129968 - Homo sapiens cDNA FLJ26458 fis, clone KDN03752, highly similar to Zinc finger protein 288. BC015587 - Homo sapiens cDNA clone IMAGE:4642585, containing frame-shift errors. AF139460 - Homo sapiens BTB/POZ zinc finger protein DPZF mRNA, complete cds. AK290116 - Homo sapiens cDNA FLJ77884 complete cds. KJ898599 - Synthetic construct Homo sapiens clone ccsbBroadEn_07993 ZBTB20 gene, encodes complete protein. EU446790 - Synthetic construct Homo sapiens clone IMAGE:100070268; IMAGE:100011999; FLH258731.01L zinc finger and BTB domain containing 20 (ZBTB20) gene, encodes complete protein. AB464364 - Synthetic construct DNA, clone: pF1KB8322, Homo sapiens ZBTB20 gene for zinc finger and BTB domain containing protein 20, without stop codon, in Flexi system. AM392598 - Synthetic construct Homo sapiens clone IMAGE:100001797 for hypothetical protein (ZBTB20 gene). CU688586 - Synthetic construct Homo sapiens gateway clone IMAGE:100019995 5' read ZBTB20 mRNA. JD402353 - Sequence 383377 from Patent EP1572962. JD170337 - Sequence 151361 from Patent EP1572962. JD529002 - Sequence 510026 from Patent EP1572962. MA646075 - JP 2017113010-A/3999: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA733959 - JP 2017140048-A/2829: TERMINALLY MODIFIED RNA. MA803128 - JP 2018183181-A/3999: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

Other Names for This Gene


	Alternate Gene Symbols: DPZF, NM_001348803, Q63HP6, Q8N6R5, Q9HC78, Q9Y410, uc329ztw.1, uc329ztw.2, ZBT20_HUMAN, ZNF288 UCSC ID: ENST00000675478.1_6 RefSeq Accession: NM_001348800.3 Protein: Q9HC78 (aka ZBT20_HUMAN or ZB20_HUMAN)

GeneReviews for This Gene


	GeneReviews article(s) related to gene ZBTB20: primrose (Primrose Syndrome)

Gene Model Information


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Methods, Credits, and Use Restrictions


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