ID:1433G_HUMAN DESCRIPTION: RecName: Full=14-3-3 protein gamma; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1; Contains: RecName: Full=14-3-3 protein gamma, N-terminally processed; FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. SUBUNIT: Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. INTERACTION: Q14678-2:KANK1; NbExp=3; IntAct=EBI-359832, EBI-6173812; Q7KZI7:MARK2; NbExp=2; IntAct=EBI-359832, EBI-516560; P27448:MARK3; NbExp=2; IntAct=EBI-359832, EBI-707595; P62258:YWHAE; NbExp=4; IntAct=EBI-359832, EBI-356498; SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Highly expressed in brain, skeletal muscle, and heart. PTM: Phosphorylated by various PKC isozymes. SIMILARITY: Belongs to the 14-3-3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61981
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003723 RNA binding GO:0005080 protein kinase C binding GO:0005159 insulin-like growth factor receptor binding GO:0005515 protein binding GO:0008426 protein kinase C inhibitor activity GO:0019904 protein domain specific binding GO:0030971 receptor tyrosine kinase binding GO:0042802 identical protein binding
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0006469 negative regulation of protein kinase activity GO:0006605 protein targeting GO:0009966 regulation of signal transduction GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0032869 cellular response to insulin stimulus GO:0045664 regulation of neuron differentiation GO:0048167 regulation of synaptic plasticity GO:0061024 membrane organization GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0097711 ciliary basal body docking GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
AB024334 - Homo sapiens mRNA for 14-3-3gamma, complete cds. BC020963 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, mRNA (cDNA clone MGC:8908 IMAGE:3915246), complete cds. AK024230 - Homo sapiens cDNA FLJ14168 fis, clone NT2RP2001440, highly similar to 14-3-3 protein gamma. JD377370 - Sequence 358394 from Patent EP1572962. JD375680 - Sequence 356704 from Patent EP1572962. JD087237 - Sequence 68261 from Patent EP1572962. JD100666 - Sequence 81690 from Patent EP1572962. JD357394 - Sequence 338418 from Patent EP1572962. JD540106 - Sequence 521130 from Patent EP1572962. JD244865 - Sequence 225889 from Patent EP1572962. JD166271 - Sequence 147295 from Patent EP1572962. JD510667 - Sequence 491691 from Patent EP1572962. JD073249 - Sequence 54273 from Patent EP1572962. JD239522 - Sequence 220546 from Patent EP1572962. JD139421 - Sequence 120445 from Patent EP1572962. JD419978 - Sequence 401002 from Patent EP1572962. JD224049 - Sequence 205073 from Patent EP1572962. JD232920 - Sequence 213944 from Patent EP1572962. JD518865 - Sequence 499889 from Patent EP1572962. JD039298 - Sequence 20322 from Patent EP1572962. JD245271 - Sequence 226295 from Patent EP1572962. JD239532 - Sequence 220556 from Patent EP1572962. JD415949 - Sequence 396973 from Patent EP1572962. JD062538 - Sequence 43562 from Patent EP1572962. JD057037 - Sequence 38061 from Patent EP1572962. JD394512 - Sequence 375536 from Patent EP1572962. JD530383 - Sequence 511407 from Patent EP1572962. JD440300 - Sequence 421324 from Patent EP1572962. JD344820 - Sequence 325844 from Patent EP1572962. JD350787 - Sequence 331811 from Patent EP1572962. JD279745 - Sequence 260769 from Patent EP1572962. AK295029 - Homo sapiens cDNA FLJ51843 complete cds, highly similar to 14-3-3 protein gamma. JD059190 - Sequence 40214 from Patent EP1572962. JD103527 - Sequence 84551 from Patent EP1572962. JD156635 - Sequence 137659 from Patent EP1572962. JD448925 - Sequence 429949 from Patent EP1572962. JD181848 - Sequence 162872 from Patent EP1572962. JD243609 - Sequence 224633 from Patent EP1572962. JD359780 - Sequence 340804 from Patent EP1572962. JD377603 - Sequence 358627 from Patent EP1572962. JD386437 - Sequence 367461 from Patent EP1572962. AK293505 - Homo sapiens cDNA FLJ52141 complete cds, highly similar to 14-3-3 protein gamma. CR541904 - Homo sapiens full open reading frame cDNA clone RZPDo834H0133D for gene YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; complete cds, incl. stopcodon. CU676788 - Synthetic construct Homo sapiens gateway clone IMAGE:100016886 5' read YWHAG mRNA. KJ897748 - Synthetic construct Homo sapiens clone ccsbBroadEn_07142 YWHAG gene, encodes complete protein. AB384983 - Synthetic construct DNA, clone: pF1KB4712, Homo sapiens YWHAG gene for 14-3-3 protein gamma, complete cds, without stop codon, in Flexi system. CR541925 - Homo sapiens full open reading frame cDNA clone RZPDo834F1133D for gene YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; complete cds, without stopcodon. AF142498 - Homo sapiens 14-3-3 gamma protein mRNA, complete cds. DQ600310 - Homo sapiens piRNA piR-38376, complete sequence. JD109287 - Sequence 90311 from Patent EP1572962. JD122376 - Sequence 103400 from Patent EP1572962. JD124055 - Sequence 105079 from Patent EP1572962. JD520542 - Sequence 501566 from Patent EP1572962. JD150419 - Sequence 131443 from Patent EP1572962. JD187551 - Sequence 168575 from Patent EP1572962. JD187215 - Sequence 168239 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P61981 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-75016 Association of p-S216-CDC25C with 14-3-3 proteins R-HSA-139899 Sequestration of BAD protein by 14-3-3 R-HSA-1445149 14-3-3 binds p-5S,T642-AS160 (TBC1D4) R-HSA-1454689 14-3-3 Binds p-S237-TBC1D1 R-HSA-5632732 p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 R-HSA-5632738 DDIT4 binds 14-3-3 dimer R-HSA-139906 Activation of BAD by calcineurin R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-5625740 RHO GTPases activate PKNs R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of GLUT4 to the plasma membrane R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-69473 G2/M DNA damage checkpoint R-HSA-195258 RHO GTPase Effectors R-HSA-114452 Activation of BH3-only proteins R-HSA-199991 Membrane Trafficking R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69481 G2/M Checkpoints R-HSA-194315 Signaling by Rho GTPases R-HSA-109606 Intrinsic Pathway for Apoptosis R-HSA-5653656 Vesicle-mediated transport R-HSA-212436 Generic Transcription Pathway R-HSA-69278 Cell Cycle (Mitotic) R-HSA-69620 Cell Cycle Checkpoints R-HSA-162582 Signal Transduction R-HSA-109581 Apoptosis R-HSA-73857 RNA Polymerase II Transcription R-HSA-1640170 Cell Cycle R-HSA-5357801 Programmed Cell Death R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
