Human Gene YWHAE (ENST00000264335.13_7) from GENCODE V47lift37
  Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon, transcript variant 1 (from RefSeq NM_006761.5)
Gencode Transcript: ENST00000264335.13_7
Gencode Gene: ENSG00000108953.17_13
Transcript (Including UTRs)
   Position: hg19 chr17:1,247,569-1,303,516 Size: 55,948 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr17:1,248,741-1,303,404 Size: 54,664 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:1,247,569-1,303,516)mRNA (may differ from genome)Protein (255 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: YWHAE
Diseases sorted by gene-association score: endometrial stromal sarcoma* (211), kidney clear cell sarcoma* (202), miller-dieker lissencephaly syndrome* (94), distal 17p13.3 microdeletion syndrome* (25), chromosome 17p13.3, centromeric, duplication syndrome* (23), endometrial stromal nodule (3), left ventricular noncompaction (3), juvenile astrocytoma (3), neuronal migration disorders (2), ohdo syndrome (2), tricuspid valve stenosis (1), mental retardation, x-linked syndromic, lubs type (1), retinitis pigmentosa (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C023514 2,6-dinitrotoluene
  • C496186 2-trans-4-trans-decadienal
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C119130 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D000643 Ammonium Chloride
  • D001151 Arsenic
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 291.11 RPKM in Brain - Amygdala
Total median expression: 7322.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.20112-0.332 Picture PostScript Text
3' UTR -273.001172-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Descriptions from all associated GenBank mRNAs
  BC000179 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, mRNA (cDNA clone MGC:5005 IMAGE:2900956), complete cds.
AY883089 - Homo sapiens 14-3-3 protein epsilon isoform transcript variant 1 (YWHAE) mRNA, complete cds, alternatively spliced.
AK128785 - Homo sapiens cDNA FLJ45465 fis, clone BRSTN2012174, highly similar to 14-3-3 protein epsilon (14-3-3E).
AX775995 - Sequence 265 from Patent WO03048202.
U43399 - Human 14-3-3 protein epsilon isoform mRNA, complete cds.
U43430 - Human epsilon isoform 14-3-3 protein mRNA, complete cds.
BC001440 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, mRNA (cDNA clone MGC:1250 IMAGE:3139004), complete cds.
EU794581 - Homo sapiens epididymis luminal protein 2 (HEL2) mRNA, complete cds.
U54778 - Human 14-3-3 epsilon mRNA, complete cds.
JD333901 - Sequence 314925 from Patent EP1572962.
JD032034 - Sequence 13058 from Patent EP1572962.
JD024580 - Sequence 5604 from Patent EP1572962.
JD151417 - Sequence 132441 from Patent EP1572962.
JD151416 - Sequence 132440 from Patent EP1572962.
JD413597 - Sequence 394621 from Patent EP1572962.
JD126728 - Sequence 107752 from Patent EP1572962.
JD554829 - Sequence 535853 from Patent EP1572962.
JD399036 - Sequence 380060 from Patent EP1572962.
JD240076 - Sequence 221100 from Patent EP1572962.
JD163625 - Sequence 144649 from Patent EP1572962.
L13388 - Homo sapiens (clone 8-1) Miller-Dieker lissencephaly protein (LIS1) mRNA.
JD354906 - Sequence 335930 from Patent EP1572962.
JD231677 - Sequence 212701 from Patent EP1572962.
AK316185 - Homo sapiens cDNA, FLJ79084 complete cds, highly similar to 14-3-3 protein epsilon (14-3-3E).
AK295260 - Homo sapiens cDNA FLJ51851 complete cds, highly similar to 14-3-3 protein epsilon (14-3-3E).
AK316201 - Homo sapiens cDNA, FLJ79100 complete cds, highly similar to 14-3-3 protein epsilon (14-3-3E).
JD235182 - Sequence 216206 from Patent EP1572962.
JD352165 - Sequence 333189 from Patent EP1572962.
JD454743 - Sequence 435767 from Patent EP1572962.
JD533973 - Sequence 514997 from Patent EP1572962.
JD551628 - Sequence 532652 from Patent EP1572962.
JD096332 - Sequence 77356 from Patent EP1572962.
JD387899 - Sequence 368923 from Patent EP1572962.
U20972 - Human 14-3-3 protein epsilon isoform mRNA, complete cds.
AK296050 - Homo sapiens cDNA FLJ51975 complete cds, moderately similar to 14-3-3 protein epsilon (14-3-3E).
AK295997 - Homo sapiens cDNA FLJ60092 complete cds, highly similar to 14-3-3 protein epsilon (14-3-3E).
JD110022 - Sequence 91046 from Patent EP1572962.
U28936 - Human epsilon 14-3-3 protein mRNA, complete cds.
CU674076 - Synthetic construct Homo sapiens gateway clone IMAGE:100018617 5' read YWHAE mRNA.
KJ904589 - Synthetic construct Homo sapiens clone ccsbBroadEn_13983 YWHAE-like gene, encodes complete protein.
BT007161 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide mRNA, complete cds.
EU176525 - Synthetic construct Homo sapiens clone IMAGE:100011640; FLH263998.01L; RZPDo839C09245D tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (YWHAE) gene, encodes complete protein.
AB590347 - Synthetic construct DNA, clone: pFN21AE2194, Homo sapiens YWHAE gene for tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, without stop codon, in Flexi system.
JN999698 - Homo sapiens YWHAE/FAM22A fusion protein (YWHAE/FAM22A fusion) mRNA, partial cds.
JN999699 - Homo sapiens YWHAE/FAM22B fusion protein (YWHAE/FAM22B fusion) mRNA, partial cds.
DL490421 - Novel nucleic acids.
AK296555 - Homo sapiens cDNA FLJ53559 complete cds.
DL492455 - Novel nucleic acids.
DL490933 - Novel nucleic acids.
JD163421 - Sequence 144445 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000264335.1, ENST00000264335.10, ENST00000264335.11, ENST00000264335.12, ENST00000264335.2, ENST00000264335.3, ENST00000264335.4, ENST00000264335.5, ENST00000264335.6, ENST00000264335.7, ENST00000264335.8, ENST00000264335.9, HEL2 , NM_006761, uc317hrj.1, uc317hrj.2, V9HW98, V9HW98_HUMAN
UCSC ID: ENST00000264335.13_7
RefSeq Accession: NM_006761.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.