Human Gene YPEL4 (ENST00000300022.8_7) from GENCODE V47lift37

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Description: yippee like 4, transcript variant 2 (from RefSeq NM_145008.3)
Gencode Transcript: ENST00000300022.8_7
Gencode Gene: ENSG00000166793.13_11
Transcript (Including UTRs)
Position: hg19 chr11:57,412,560-57,417,385 Size: 4,826 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr11:57,413,454-57,414,580 Size: 1,127 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:57,412,560-57,417,385)			mRNA (may differ from genome)		Protein (127 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: YPEL4_HUMAN DESCRIPTION: RecName: Full=Protein yippee-like 4; SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Widely expressed. Detected adult brain, lung, colon, small intestine and ovary, and in fetal brain, lung, liver and spleen. SIMILARITY: Belongs to the yippee family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C547126 AZM551248 D001564 Benzo(a)pyrene D002794 Choline D005492 Folic Acid D008715 Methionine D012999 Soman C069837 fullerene C60 C500085 muraglitazar C089730 rosiglitazone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 75.19 RPKM in Brain - Cerebellum Total median expression: 481.95 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-130.20	412	-0.316	Picture	PostScript	Text
3' UTR	-337.00	894	-0.377	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004910 - Yippee

Pfam Domains:
PF03226 - Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q96NS1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0046872 metal ion binding Cellular Component: GO:0005634 nucleus GO:0005730 nucleolus

Descriptions from all associated GenBank mRNAs


	BC111012 - Homo sapiens yippee-like 4 (Drosophila), mRNA (cDNA clone IMAGE:5767593), complete cds. BC064995 - Homo sapiens yippee-like 4 (Drosophila), mRNA (cDNA clone IMAGE:5722221). AB098738 - Homo sapiens YPEL4 mRNA for yippee-like 4, complete cds. AK054967 - Homo sapiens cDNA FLJ30405 fis, clone BRACE2008488, highly similar to Protein yippee-like 4. AK054775 - Homo sapiens cDNA FLJ30213 fis, clone BRACE2001673, highly similar to Mus musculus mdgl-1 mRNA. AK124577 - Homo sapiens cDNA FLJ42586 fis, clone BRACE3009297, highly similar to Protein yippee-like 4. BC029228 - Homo sapiens yippee-like 4 (Drosophila), mRNA (cDNA clone IMAGE:5172948), complete cds. JD433439 - Sequence 414463 from Patent EP1572962. JD479706 - Sequence 460730 from Patent EP1572962. JD166850 - Sequence 147874 from Patent EP1572962. BC104781 - Homo sapiens yippee-like 4 (Drosophila), mRNA (cDNA clone MGC:132441 IMAGE:8143784), complete cds. BC112119 - Homo sapiens yippee-like 4 (Drosophila), mRNA (cDNA clone MGC:138324 IMAGE:8327587), complete cds. JD237014 - Sequence 218038 from Patent EP1572962. JD407859 - Sequence 388883 from Patent EP1572962. JD319065 - Sequence 300089 from Patent EP1572962. JD369466 - Sequence 350490 from Patent EP1572962. JD378523 - Sequence 359547 from Patent EP1572962. JD148942 - Sequence 129966 from Patent EP1572962. JD343673 - Sequence 324697 from Patent EP1572962. JD561651 - Sequence 542675 from Patent EP1572962. JD079212 - Sequence 60236 from Patent EP1572962. JD068864 - Sequence 49888 from Patent EP1572962. JD527137 - Sequence 508161 from Patent EP1572962. JD390918 - Sequence 371942 from Patent EP1572962. JD390566 - Sequence 371590 from Patent EP1572962. JD417005 - Sequence 398029 from Patent EP1572962. KJ895830 - Synthetic construct Homo sapiens clone ccsbBroadEn_05224 YPEL4 gene, encodes complete protein. JD384161 - Sequence 365185 from Patent EP1572962. JD108618 - Sequence 89642 from Patent EP1572962. JD452351 - Sequence 433375 from Patent EP1572962. JD195915 - Sequence 176939 from Patent EP1572962. JD124328 - Sequence 105352 from Patent EP1572962. JD104499 - Sequence 85523 from Patent EP1572962. JD393206 - Sequence 374230 from Patent EP1572962. JD443954 - Sequence 424978 from Patent EP1572962. JD044433 - Sequence 25457 from Patent EP1572962. JD117956 - Sequence 98980 from Patent EP1572962. JD114930 - Sequence 95954 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B3KW92, ENST00000300022.1, ENST00000300022.2, ENST00000300022.3, ENST00000300022.4, ENST00000300022.5, ENST00000300022.6, ENST00000300022.7, NM_145008, Q2M3U7, Q65Z98, Q96NS1, uc317mmv.1, uc317mmv.2, YPEL4_HUMAN UCSC ID: ENST00000300022.8_7 RefSeq Accession: NM_145008.3 Protein: Q96NS1 (aka YPEL4_HUMAN or YPL4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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