Human Gene YPEL3 (ENST00000398841.6_7) from GENCODE V47lift37
  Description: yippee like 3, transcript variant 1 (from RefSeq NM_031477.5)
Gencode Transcript: ENST00000398841.6_7
Gencode Gene: ENSG00000090238.12_15
Transcript (Including UTRs)
   Position: hg19 chr16:30,103,635-30,107,534 Size: 3,900 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr16:30,104,031-30,106,803 Size: 2,773 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,103,635-30,107,534)mRNA (may differ from genome)Protein (157 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: YPEL3_HUMAN
DESCRIPTION: RecName: Full=Protein yippee-like 3;
FUNCTION: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Widely expressed.
PTM: Probably ubiquitinated leading to its degradation by the proteasome (By similarity).
SIMILARITY: Belongs to the yippee family.
SEQUENCE CAUTION: Sequence=EAW79925.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 127.56 RPKM in Whole Blood
Total median expression: 1916.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -311.00731-0.425 Picture PostScript Text
3' UTR -142.50396-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004910 - Yippee

Pfam Domains:
PF03226 - Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on P61236
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:2000774 positive regulation of cellular senescence

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  LF207899 - JP 2014500723-A/15402: Polycomb-Associated Non-Coding RNAs.
BC005009 - Homo sapiens yippee-like 3 (Drosophila), mRNA (cDNA clone MGC:10500 IMAGE:3639517), complete cds.
BC050664 - Homo sapiens yippee-like 3 (Drosophila), mRNA (cDNA clone MGC:60184 IMAGE:5748830), complete cds.
AB098737 - Homo sapiens YPEL3 mRNA for yippee-like 3, complete cds.
AF305622 - Homo sapiens DiGeorge syndrome-related protein FKSG5 mRNA, complete cds.
JD485319 - Sequence 466343 from Patent EP1572962.
JD565401 - Sequence 546425 from Patent EP1572962.
JD391537 - Sequence 372561 from Patent EP1572962.
JD149208 - Sequence 130232 from Patent EP1572962.
JD517140 - Sequence 498164 from Patent EP1572962.
JD057083 - Sequence 38107 from Patent EP1572962.
JD282857 - Sequence 263881 from Patent EP1572962.
JD125042 - Sequence 106066 from Patent EP1572962.
KJ906353 - Synthetic construct Homo sapiens clone ccsbBroadEn_16023 YPEL3 gene, encodes complete protein.
KJ903359 - Synthetic construct Homo sapiens clone ccsbBroadEn_12753 YPEL3 gene, encodes complete protein.
AK026047 - Homo sapiens cDNA: FLJ22394 fis, clone HRC07882.
AK022409 - Homo sapiens cDNA FLJ12347 fis, clone MAMMA1002298.
MA443476 - JP 2018138019-A/15402: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000398841.1, ENST00000398841.2, ENST00000398841.3, ENST00000398841.4, ENST00000398841.5, FKSG5, NM_031477, P61236, Q65Z99, Q86VK6, Q9BSJ4, Q9CQB6, uc318zzb.1, uc318zzb.2, YPEL3_HUMAN
UCSC ID: ENST00000398841.6_7
RefSeq Accession: NM_031477.5
Protein: P61236 (aka YPEL3_HUMAN or YPL3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.