ID:DBPA_HUMAN DESCRIPTION: RecName: Full=DNA-binding protein A; AltName: Full=Cold shock domain-containing protein A; AltName: Full=Single-strand DNA-binding protein NF-GMB; FUNCTION: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). SUBUNIT: Found in a mRNP complex with YBX2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Highly expressed in skeletal muscle and heart. SIMILARITY: Contains 1 CSD (cold-shock) domain. SEQUENCE CAUTION: Sequence=AAA35749.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16989
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003697 single-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0003723 RNA binding GO:0003730 mRNA 3'-UTR binding GO:0005515 protein binding GO:0017048 Rho GTPase binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001701 in utero embryonic development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007283 spermatogenesis GO:0008584 male gonad development GO:0009409 response to cold GO:0009566 fertilization GO:0043066 negative regulation of apoptotic process GO:0046622 positive regulation of organ growth GO:0048642 negative regulation of skeletal muscle tissue development GO:0060546 negative regulation of necroptotic process GO:0070935 3'-UTR-mediated mRNA stabilization GO:0071356 cellular response to tumor necrosis factor GO:0071474 cellular hyperosmotic response GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:2000767 positive regulation of cytoplasmic translation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
