ID:XRN2_HUMAN DESCRIPTION: RecName: Full=5'-3' exoribonuclease 2; EC=3.1.13.-; AltName: Full=DHM1-like protein; Short=DHP protein; FUNCTION: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. CATALYTIC ACTIVITY: Exonucleolytic cleavage in the 5'- to 3'- direction to yield nucleoside 5'-phosphates. SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. SIMILARITY: Contains 1 CCHC-type zinc finger. SEQUENCE CAUTION: Sequence=AAR24369.1; Type=Frameshift; Positions=73; Sequence=BAA90934.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0D6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9H0D6 (Reactome details) participates in the following event(s):
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-390466 Chaperonin-mediated protein folding R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-391251 Protein folding R-HSA-72312 rRNA processing R-HSA-392499 Metabolism of proteins R-HSA-8953854 Metabolism of RNA
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
