ID:XBP1_HUMAN DESCRIPTION: RecName: Full=X-box-binding protein 1; Short=XBP-1; AltName: Full=Tax-responsive element-binding protein 5; FUNCTION: Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax- responsive element (TRE) of HTLV-I. SUBCELLULAR LOCATION: Nucleus. INDUCTION: Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. DISEASE: Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. SIMILARITY: Belongs to the bZIP family. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain
ModBase Predicted Comparative 3D Structure on P17861
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001047 core promoter binding GO:0001085 RNA polymerase II transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0002020 protease binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0019901 protein kinase binding GO:0030331 estrogen receptor binding GO:0031490 chromatin DNA binding GO:0031625 ubiquitin protein ligase binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001525 angiogenesis GO:0001889 liver development GO:0001934 positive regulation of protein phosphorylation GO:0001935 endothelial cell proliferation GO:0002070 epithelial cell maturation GO:0002639 positive regulation of immunoglobulin production GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006511 ubiquitin-dependent protein catabolic process GO:0006629 lipid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006914 autophagy GO:0006915 apoptotic process GO:0006955 immune response GO:0006986 response to unfolded protein GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0006996 organelle organization GO:0007275 multicellular organism development GO:0007517 muscle organ development GO:0008284 positive regulation of cell proliferation GO:0010506 regulation of autophagy GO:0010508 positive regulation of autophagy GO:0010832 negative regulation of myotube differentiation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0015031 protein transport GO:0016049 cell growth GO:0030154 cell differentiation GO:0030335 positive regulation of cell migration GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030968 endoplasmic reticulum unfolded protein response GO:0031017 exocrine pancreas development GO:0031062 positive regulation of histone methylation GO:0031647 regulation of protein stability GO:0031648 protein destabilization GO:0031670 cellular response to nutrient GO:0032008 positive regulation of TOR signaling GO:0032869 cellular response to insulin stimulus GO:0034599 cellular response to oxidative stress GO:0034976 response to endoplasmic reticulum stress GO:0035356 cellular triglyceride homeostasis GO:0035470 positive regulation of vascular wound healing GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0036498 IRE1-mediated unfolded protein response GO:0036500 ATF6-mediated unfolded protein response GO:0042149 cellular response to glucose starvation GO:0042307 positive regulation of protein import into nucleus GO:0042593 glucose homeostasis GO:0042632 cholesterol homeostasis GO:0043066 negative regulation of apoptotic process GO:0045348 positive regulation of MHC class II biosynthetic process GO:0045579 positive regulation of B cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045766 positive regulation of angiogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048666 neuron development GO:0051024 positive regulation of immunoglobulin secretion GO:0051897 positive regulation of protein kinase B signaling GO:0055089 fatty acid homeostasis GO:0055092 sterol homeostasis GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation GO:0060612 adipose tissue development GO:0060691 epithelial cell maturation involved in salivary gland development GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0071222 cellular response to lipopolysaccharide GO:0071230 cellular response to amino acid stimulus GO:0071332 cellular response to fructose stimulus GO:0071333 cellular response to glucose stimulus GO:0071353 cellular response to interleukin-4 GO:0071375 cellular response to peptide hormone stimulus GO:0071498 cellular response to fluid shear stress GO:0071499 cellular response to laminar fluid shear stress GO:1900100 positive regulation of plasma cell differentiation GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response GO:1900413 positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter GO:1901800 positive regulation of proteasomal protein catabolic process GO:1901985 positive regulation of protein acetylation GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903489 positive regulation of lactation GO:1904707 positive regulation of vascular smooth muscle cell proliferation GO:1904754 positive regulation of vascular associated smooth muscle cell migration GO:1990418 response to insulin-like growth factor stimulus GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990830 cellular response to leukemia inhibitory factor GO:2000347 positive regulation of hepatocyte proliferation GO:2000353 positive regulation of endothelial cell apoptotic process GO:2000778 positive regulation of interleukin-6 secretion
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Common Gene Haplotype Alleles 
