ID:WSB1_HUMAN DESCRIPTION: RecName: Full=WD repeat and SOCS box-containing protein 1; Short=WSB-1; AltName: Full=SOCS box-containing WD protein SWiP-1; FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Binds to HIPK2 through WD40 repeats. INTERACTION: Q9QZR5:Hipk2 (xeno); NbExp=5; IntAct=EBI-1171494, EBI-366905; DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Contains 1 SOCS box domain. SIMILARITY: Contains 6 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6I7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding
Biological Process: GO:0000209 protein polyubiquitination GO:0008150 biological_process GO:0016567 protein ubiquitination GO:0035556 intracellular signal transduction GO:0043687 post-translational protein modification
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
