Human Gene WNT5A (ENST00000264634.9_7) from GENCODE V47lift37
  Description: Wnt family member 5A, transcript variant 1 (from RefSeq NM_003392.7)
Gencode Transcript: ENST00000264634.9_7
Gencode Gene: ENSG00000114251.15_13
Transcript (Including UTRs)
   Position: hg19 chr3:55,499,743-55,521,334 Size: 21,592 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr3:55,504,120-55,521,013 Size: 16,894 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:55,499,743-55,521,334)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WNT5A_HUMAN
DESCRIPTION: RecName: Full=Protein Wnt-5a; Flags: Precursor;
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
SUBUNIT: Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
PTM: Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding (By similarity).
PTM: Glycosylation is necessary for secretion but not for activity (By similarity).
PTM: Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-104. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).
PTM: Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A (By similarity).
DISEASE: Defects in WNT5A are the cause of Robinow syndrome autosomal dominant (DRS) [MIM:180700]. A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
SIMILARITY: Belongs to the Wnt family.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/WNT5AID42825ch3p14.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: WNT5A
Diseases sorted by gene-association score: robinow syndrome, autosomal dominant 1* (1330), robinow syndrome* (456), autosomal dominant robinow syndrome* (379), zimmermann-laband syndrome (11), mayer-rokitansky-kuster-hauser syndrome (9), estrogen-receptor negative breast cancer (9), epstein-barr virus-associated gastric carcinoma (8), hallermann-streiff syndrome (5), breast cancer (3), colorectal cancer (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.51 RPKM in Cells - Cultured fibroblasts
Total median expression: 140.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -135.00321-0.421 Picture PostScript Text
3' UTR -1026.604377-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005817 - Wnt
IPR026538 - Wnt5a
IPR018161 - Wnt_CS

Pfam Domains:
PF00110 - wnt family

ModBase Predicted Comparative 3D Structure on P41221
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005115 receptor tyrosine kinase-like orphan receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0019904 protein domain specific binding
GO:0044212 transcription regulatory region DNA binding
GO:0048018 receptor agonist activity
GO:1902379 chemoattractant activity involved in axon guidance

Biological Process:
GO:0000187 activation of MAPK activity
GO:0001667 ameboidal-type cell migration
GO:0001736 establishment of planar polarity
GO:0001756 somitogenesis
GO:0001819 positive regulation of cytokine production
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0002009 morphogenesis of an epithelium
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0003323 type B pancreatic cell development
GO:0003344 pericardium morphogenesis
GO:0003401 axis elongation
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0003408 optic cup formation involved in camera-type eye development
GO:0006468 protein phosphorylation
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007275 multicellular organism development
GO:0007368 determination of left/right symmetry
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007442 hindgut morphogenesis
GO:0007494 midgut development
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0008595 anterior/posterior axis specification, embryo
GO:0009952 anterior/posterior pattern specification
GO:0010033 response to organic substance
GO:0010469 regulation of receptor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010820 positive regulation of T cell chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0021891 olfactory bulb interneuron development
GO:0021915 neural tube development
GO:0022008 neurogenesis
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030514 negative regulation of BMP signaling pathway
GO:0030825 positive regulation of cGMP metabolic process
GO:0030901 midbrain development
GO:0032092 positive regulation of protein binding
GO:0032148 activation of protein kinase B activity
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0032880 regulation of protein localization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035108 limb morphogenesis
GO:0035567 non-canonical Wnt signaling pathway
GO:0036342 post-anal tail morphogenesis
GO:0036517 chemoattraction of serotonergic neuron axon
GO:0036518 chemorepulsion of dopaminergic neuron axon
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042472 inner ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507 positive regulation of JUN kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045165 cell fate commitment
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045807 positive regulation of endocytosis
GO:0045836 positive regulation of meiotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046546 development of primary male sexual characteristics
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048341 paraxial mesoderm formation
GO:0048546 digestive tract morphogenesis
GO:0048570 notochord morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048806 genitalia development
GO:0048812 neuron projection morphogenesis
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048850 hypophysis morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050919 negative chemotaxis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0051885 positive regulation of anagen
GO:0051964 negative regulation of synapse assembly
GO:0060026 convergent extension
GO:0060028 convergent extension involved in axis elongation
GO:0060029 convergent extension involved in organogenesis
GO:0060065 uterus development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060157 urinary bladder development
GO:0060324 face development
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060606 tube closure
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060744 mammary gland branching involved in thelarche
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0060809 mesodermal to mesenchymal transition involved in gastrulation
GO:0060907 positive regulation of macrophage cytokine production
GO:0061024 membrane organization
GO:0061036 positive regulation of cartilage development
GO:0061053 somite development
GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071300 cellular response to retinoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071425 hematopoietic stem cell proliferation
GO:0071542 dopaminergic neuron differentiation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0090009 primitive streak formation
GO:0090037 positive regulation of protein kinase C signaling
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090630 activation of GTPase activity
GO:0097325 melanocyte proliferation
GO:0099054 presynapse assembly
GO:0099068 postsynapse assembly
GO:1900020 positive regulation of protein kinase C activity
GO:1901216 positive regulation of neuron death
GO:1902474 positive regulation of protein localization to synapse
GO:1903827 regulation of cellular protein localization
GO:1904469 positive regulation of tumor necrosis factor secretion
GO:1904861 excitatory synapse assembly
GO:1904862 inhibitory synapse assembly
GO:1904934 negative regulation of cell proliferation in midbrain
GO:1904938 planar cell polarity pathway involved in axon guidance
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1904955 planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000484 positive regulation of interleukin-8 secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0030665 clathrin-coated vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC064694 - Homo sapiens wingless-type MMTV integration site family, member 5A, mRNA (cDNA clone MGC:71588 IMAGE:30346200), complete cds.
GQ891372 - Homo sapiens clone HEL-S-160l epididymis secretory sperm binding protein mRNA, complete cds.
AK021503 - Homo sapiens cDNA FLJ11441 fis, clone HEMBA1001323.
LF209977 - JP 2014500723-A/17480: Polycomb-Associated Non-Coding RNAs.
AK090582 - Homo sapiens cDNA FLJ33263 fis, clone ASTRO2006732, highly similar to Protein Wnt-5a precursor.
LF333629 - JP 2014500723-A/141132: Polycomb-Associated Non-Coding RNAs.
L20861 - Homo sapiens proto-oncogene (Wnt-5a) mRNA, complete cds.
LF214006 - JP 2014500723-A/21509: Polycomb-Associated Non-Coding RNAs.
JD296414 - Sequence 277438 from Patent EP1572962.
JD044235 - Sequence 25259 from Patent EP1572962.
JD208412 - Sequence 189436 from Patent EP1572962.
JD251797 - Sequence 232821 from Patent EP1572962.
JD054974 - Sequence 35998 from Patent EP1572962.
JD513752 - Sequence 494776 from Patent EP1572962.
LF333628 - JP 2014500723-A/141131: Polycomb-Associated Non-Coding RNAs.
JD500245 - Sequence 481269 from Patent EP1572962.
JD256233 - Sequence 237257 from Patent EP1572962.
JD238841 - Sequence 219865 from Patent EP1572962.
JD316599 - Sequence 297623 from Patent EP1572962.
JD285007 - Sequence 266031 from Patent EP1572962.
JD402483 - Sequence 383507 from Patent EP1572962.
JD168187 - Sequence 149211 from Patent EP1572962.
LF333627 - JP 2014500723-A/141130: Polycomb-Associated Non-Coding RNAs.
JD112730 - Sequence 93754 from Patent EP1572962.
LF333626 - JP 2014500723-A/141129: Polycomb-Associated Non-Coding RNAs.
JD359960 - Sequence 340984 from Patent EP1572962.
JD512419 - Sequence 493443 from Patent EP1572962.
JD544748 - Sequence 525772 from Patent EP1572962.
JD557069 - Sequence 538093 from Patent EP1572962.
LF333625 - JP 2014500723-A/141128: Polycomb-Associated Non-Coding RNAs.
JD239842 - Sequence 220866 from Patent EP1572962.
LF333624 - JP 2014500723-A/141127: Polycomb-Associated Non-Coding RNAs.
AK290375 - Homo sapiens cDNA FLJ76090 complete cds, highly similar to Homo sapiens wingless-type MMTV integration site family, member 5A (WNT5A), mRNA.
AK290869 - Homo sapiens cDNA FLJ75164 complete cds, highly similar to Homo sapiens wingless-type MMTV integration site family, member 5A(WNT5A), mRNA.
EF028086 - Homo sapiens wingless-type MMTV integration site family member 5A precursor variant 2 (WNT5A) mRNA, complete cds.
BC074783 - Homo sapiens wingless-type MMTV integration site family, member 5A, mRNA (cDNA clone IMAGE:30915338), partial cds.
LF333622 - JP 2014500723-A/141125: Polycomb-Associated Non-Coding RNAs.
KJ892385 - Synthetic construct Homo sapiens clone ccsbBroadEn_01779 WNT5A gene, encodes complete protein.
JF432410 - Synthetic construct Homo sapiens clone IMAGE:100073613 wingless-type MMTV integration site family, member 5A (WNT5A) gene, encodes complete protein.
AB590996 - Synthetic construct DNA, clone: pFN21AE1861, Homo sapiens WNT5A gene for wingless-type MMTV integration site family, member 5A, without stop codon, in Flexi system.
CU687936 - Synthetic construct Homo sapiens gateway clone IMAGE:100021175 5' read WNT5A mRNA.
LF333621 - JP 2014500723-A/141124: Polycomb-Associated Non-Coding RNAs.
LF333620 - JP 2014500723-A/141123: Polycomb-Associated Non-Coding RNAs.
JD202292 - Sequence 183316 from Patent EP1572962.
JD244365 - Sequence 225389 from Patent EP1572962.
JD251760 - Sequence 232784 from Patent EP1572962.
JD102831 - Sequence 83855 from Patent EP1572962.
JD525158 - Sequence 506182 from Patent EP1572962.
JD519483 - Sequence 500507 from Patent EP1572962.
LF212562 - JP 2014500723-A/20065: Polycomb-Associated Non-Coding RNAs.
LF213338 - JP 2014500723-A/20841: Polycomb-Associated Non-Coding RNAs.
MA449583 - JP 2018138019-A/21509: Polycomb-Associated Non-Coding RNAs.
MA445554 - JP 2018138019-A/17480: Polycomb-Associated Non-Coding RNAs.
MA569206 - JP 2018138019-A/141132: Polycomb-Associated Non-Coding RNAs.
MA569205 - JP 2018138019-A/141131: Polycomb-Associated Non-Coding RNAs.
MA569204 - JP 2018138019-A/141130: Polycomb-Associated Non-Coding RNAs.
MA569203 - JP 2018138019-A/141129: Polycomb-Associated Non-Coding RNAs.
MA569202 - JP 2018138019-A/141128: Polycomb-Associated Non-Coding RNAs.
MA569201 - JP 2018138019-A/141127: Polycomb-Associated Non-Coding RNAs.
MA569199 - JP 2018138019-A/141125: Polycomb-Associated Non-Coding RNAs.
MA569198 - JP 2018138019-A/141124: Polycomb-Associated Non-Coding RNAs.
MA569197 - JP 2018138019-A/141123: Polycomb-Associated Non-Coding RNAs.
MA448139 - JP 2018138019-A/20065: Polycomb-Associated Non-Coding RNAs.
MA448915 - JP 2018138019-A/20841: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P41221 (Reactome details) participates in the following event(s):

R-HSA-4551555 RYK binds WNT5A and VANGL2
R-HSA-4551571 WNT5A binds ROR2 and VANGL2
R-HSA-5099886 WNT5A binding to FZD promotes PRICKLE1 degradation
R-HSA-5099899 WNT5A binds FZD4
R-HSA-5140741 WNT5A binds FZD and ROR receptors
R-HSA-201708 Frizzled receptors bind Wnts
R-HSA-3238694 PORCN palmitoleoylates N-glycosyl WNTs
R-HSA-4551570 VANGL2 is phosphorylated in response to WNT5A
R-HSA-3247843 secretion of WNT ligands
R-HSA-3769370 WIF1 binds WNTs
R-HSA-5323545 Canonical WNT signaling through the atypical receptor RYK
R-HSA-3858491 WNTs bind the FZD receptor to initiate PCP pathway
R-HSA-3965446 WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling
R-HSA-3247840 WLS binds WNT ligands in the Golgi
R-HSA-5138441 WNT5A-FZD4 recruits DVL2
R-HSA-3858482 DVL is recruited to the receptor
R-HSA-3858480 WNT-dependent phosphorylation of DVL
R-HSA-3965441 FZD recruits trimeric G-proteins
R-HSA-3965447 G-protein subunits dissociate from WNT:FZD complex
R-HSA-5138432 DVL2 is phosphorylated by PKC
R-HSA-5138433 p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
R-HSA-3965444 WNT:FZD complex promotes G-protein nucleotide exchange
R-HSA-8866269 ARRB bind GPCRs
R-HSA-8866283 ARBB recruits GPCRs into clathrin-coated pits
R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
R-HSA-8868071 Clathrin recruits PIK3C2A
R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission
R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P
R-HSA-8871194 RAB5 and GAPVD1 bind AP-2
R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle
R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit
R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery
R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
R-HSA-8868236 BAR domain proteins recruit dynamin
R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit
R-HSA-4086400 PCP/CE pathway
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4086398 Ca2+ pathway
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-500792 GPCR ligand binding
R-HSA-195721 Signaling by WNT
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4A4, ENST00000264634.1, ENST00000264634.2, ENST00000264634.3, ENST00000264634.4, ENST00000264634.5, ENST00000264634.6, ENST00000264634.7, ENST00000264634.8, NM_003392, P41221, Q6P278, uc317htr.1, uc317htr.2, WNT5A_HUMAN
UCSC ID: ENST00000264634.9_7
RefSeq Accession: NM_003392.7
Protein: P41221 (aka WNT5A_HUMAN or WN5A_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene WNT5A:
rob-ad (Autosomal Dominant Robinow Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.