Human Gene WFDC1 (ENST00000219454.10_4) from GENCODE V47lift37

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Description: WAP four-disulfide core domain 1, transcript variant 1 (from RefSeq NM_021197.4)
Gencode Transcript: ENST00000219454.10_4
Gencode Gene: ENSG00000103175.11_7
Transcript (Including UTRs)
Position: hg19 chr16:84,328,484-84,363,450 Size: 34,967 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr16:84,328,578-84,360,546 Size: 31,969 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr16:84,328,484-84,363,450)			mRNA (may differ from genome)		Protein (220 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: WFDC1_HUMAN DESCRIPTION: RecName: Full=WAP four-disulfide core domain protein 1; AltName: Full=Prostate stromal protein ps20; AltName: Full=ps20 growth inhibitor; Flags: Precursor; FUNCTION: Has growth inhibitory activity (By similarity). SUBCELLULAR LOCATION: Secreted (Potential). SIMILARITY: Contains 1 WAP domain. SEQUENCE CAUTION: Sequence=AAG15263.1; Type=Frameshift; Positions=166, 173; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/WFDC1ID424.html";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: WFDC1 Diseases sorted by gene-association score: corneal staphyloma (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate C006253 pirinixic acid C016104 sodium bichromate C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C009505 4,4'-diaminodiphenylmethane D015122 6-Mercaptopurine D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D000643 Ammonium Chloride D001564 Benzo(a)pyrene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 56.83 RPKM in Artery - Coronary Total median expression: 521.29 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-37.10	94	-0.395	Picture	PostScript	Text
3' UTR	-149.20	538	-0.277	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008197 - Whey_acidic_protein_4-diS_core

Pfam Domains:
PF00095 - WAP-type (Whey Acidic Protein) 'four-disulfide core'

SCOP Domains:
57256 - Elafin-like

ModBase Predicted Comparative 3D Structure on Q9HC57


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity Biological Process: GO:0001558 regulation of cell growth GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0030308 negative regulation of cell growth GO:0032355 response to estradiol GO:0042493 response to drug GO:0050680 negative regulation of epithelial cell proliferation GO:0050728 negative regulation of inflammatory response GO:0061045 negative regulation of wound healing Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space

Descriptions from all associated GenBank mRNAs


	AF302109 - Homo sapiens ps20 WAP-type four-disulfide core domain protein mRNA, complete cds. AF169631 - Homo sapiens prostate stromal protein ps20 (WFDC1) mRNA, complete cds. AK075061 - Homo sapiens cDNA FLJ90580 fis, clone PLACE1000231, highly similar to WAP four-disulfide core domain protein 1 precursor. JD517014 - Sequence 498038 from Patent EP1572962. JD068062 - Sequence 49086 from Patent EP1572962. JD271770 - Sequence 252794 from Patent EP1572962. BC029159 - Homo sapiens WAP four-disulfide core domain 1, mRNA (cDNA clone MGC:34235 IMAGE:5186156), complete cds. JD191533 - Sequence 172557 from Patent EP1572962. JD424846 - Sequence 405870 from Patent EP1572962. JD539404 - Sequence 520428 from Patent EP1572962. JD457583 - Sequence 438607 from Patent EP1572962. DQ896682 - Synthetic construct Homo sapiens clone IMAGE:100011142; FLH196625.01L; RZPDo839F12155D WAP four-disulfide core domain 1 (WFDC1) gene, encodes complete protein. DQ893365 - Synthetic construct clone IMAGE:100005995; FLH196629.01X; RZPDo839F12156D WAP four-disulfide core domain 1 (WFDC1) gene, encodes complete protein. AL713785 - Homo sapiens mRNA; cDNA DKFZp547I039 (from clone DKFZp547I039). AK128711 - Homo sapiens cDNA FLJ46878 fis, clone UTERU3014906. JD348058 - Sequence 329082 from Patent EP1572962. JD514504 - Sequence 495528 from Patent EP1572962. JD439540 - Sequence 420564 from Patent EP1572962. JD131238 - Sequence 112262 from Patent EP1572962. JD117325 - Sequence 98349 from Patent EP1572962. JD239617 - Sequence 220641 from Patent EP1572962. JD351259 - Sequence 332283 from Patent EP1572962. JD255663 - Sequence 236687 from Patent EP1572962. JD207445 - Sequence 188469 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: D3DUL7, ENST00000219454.1, ENST00000219454.2, ENST00000219454.3, ENST00000219454.4, ENST00000219454.5, ENST00000219454.6, ENST00000219454.7, ENST00000219454.8, ENST00000219454.9, NM_021197, PS20, Q8NC27, Q9HAU1, Q9HC57, uc317cxo.1, uc317cxo.2, WFDC1_HUMAN UCSC ID: ENST00000219454.10_4 RefSeq Accession: NM_021197.4 Protein: Q9HC57 (aka WFDC1_HUMAN or WFD1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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