ID:WDR44_HUMAN DESCRIPTION: RecName: Full=WD repeat-containing protein 44; AltName: Full=Rabphilin-11; FUNCTION: Downstream effector for RAB11. May be involved in vesicle recycling (By similarity). SUBUNIT: Interacts with the GTP-bound form of RAB11 when membrane- associated. Does not bind to other Rab and Rho small G proteins (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAA92015.1; Type=Frameshift; Positions=792; Sequence=BAC03799.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5JSH3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.