Human Gene WDR44 (ENST00000254029.8_5) from GENCODE V47lift37
  Description: WD repeat domain 44, transcript variant 1 (from RefSeq NM_019045.5)
Gencode Transcript: ENST00000254029.8_5
Gencode Gene: ENSG00000131725.14_10
Transcript (Including UTRs)
   Position: hg19 chrX:117,480,069-117,583,924 Size: 103,856 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chrX:117,480,467-117,582,950 Size: 102,484 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:117,480,069-117,583,924)mRNA (may differ from genome)Protein (913 aa)
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-  Comments and Description Text from UniProtKB
  ID: WDR44_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 44; AltName: Full=Rabphilin-11;
FUNCTION: Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).
SUBUNIT: Interacts with the GTP-bound form of RAB11 when membrane- associated. Does not bind to other Rab and Rho small G proteins (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=BAA92015.1; Type=Frameshift; Positions=792; Sequence=BAC03799.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.34 RPKM in Artery - Tibial
Total median expression: 256.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -152.70398-0.384 Picture PostScript Text
3' UTR -216.00974-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q5JSH3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
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 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK127556 - Homo sapiens cDNA FLJ45649 fis, clone CTONG2009570, highly similar to Bos taurus rab11 binding protein.
BX537578 - Homo sapiens mRNA; cDNA DKFZp686L20145 (from clone DKFZp686L20145).
AL833605 - Homo sapiens mRNA; cDNA DKFZp686K0767 (from clone DKFZp686K0767).
BX538087 - Homo sapiens mRNA; cDNA DKFZp686F0572 (from clone DKFZp686F0572); complete cds.
AK299711 - Homo sapiens cDNA FLJ58278 complete cds, highly similar to Homo sapiens WD repeat domain 44 (WDR44), mRNA.
BX648150 - Homo sapiens mRNA; cDNA DKFZp686J0576 (from clone DKFZp686J0576).
BC028697 - Homo sapiens WD repeat domain 44, mRNA (cDNA clone MGC:26781 IMAGE:4837674), complete cds.
AM393332 - Synthetic construct Homo sapiens clone IMAGE:100002267 for hypothetical protein (WDR44 gene).
AM393787 - Synthetic construct Homo sapiens clone IMAGE:100002266 for hypothetical protein (WDR44 gene).
EU831942 - Synthetic construct Homo sapiens clone HAIB:100066971; DKFZo008D0723 WD repeat domain 44 protein (WDR44) gene, encodes complete protein.
EU832037 - Synthetic construct Homo sapiens clone HAIB:100067066; DKFZo004D0724 WD repeat domain 44 protein (WDR44) gene, encodes complete protein.
AK304432 - Homo sapiens cDNA FLJ61671 complete cds, highly similar to Homo sapiens WD repeat domain 44 (WDR44), mRNA.
AL834210 - Homo sapiens mRNA; cDNA DKFZp761M142 (from clone DKFZp761M142).
AK092077 - Homo sapiens cDNA FLJ34758 fis, clone NT2NE2001793, highly similar to Bos taurus rab11 binding protein mRNA.
KJ902658 - Synthetic construct Homo sapiens clone ccsbBroadEn_12052 WDR44 gene, encodes complete protein.
AK001978 - Homo sapiens cDNA FLJ11116 fis, clone PLACE1005966, weakly similar to TRANSCRIPTION INITIATION FACTOR TFIID 90 KD SUBUNIT.
AK023292 - Homo sapiens cDNA FLJ13230 fis, clone OVARC1000114.
JD386753 - Sequence 367777 from Patent EP1572962.
BC013924 - Homo sapiens WD repeat domain 44, mRNA (cDNA clone IMAGE:3680558), with apparent retained intron.
JD036799 - Sequence 17823 from Patent EP1572962.
JD564811 - Sequence 545835 from Patent EP1572962.
JD084464 - Sequence 65488 from Patent EP1572962.
JD080700 - Sequence 61724 from Patent EP1572962.
JD067369 - Sequence 48393 from Patent EP1572962.
JD504149 - Sequence 485173 from Patent EP1572962.
JD549738 - Sequence 530762 from Patent EP1572962.
JD044177 - Sequence 25201 from Patent EP1572962.
JD298123 - Sequence 279147 from Patent EP1572962.
JD090447 - Sequence 71471 from Patent EP1572962.
JD534194 - Sequence 515218 from Patent EP1572962.
JD490499 - Sequence 471523 from Patent EP1572962.
JD314795 - Sequence 295819 from Patent EP1572962.
JD553788 - Sequence 534812 from Patent EP1572962.
JD297321 - Sequence 278345 from Patent EP1572962.
JD566394 - Sequence 547418 from Patent EP1572962.
JD490726 - Sequence 471750 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DSE9, ENST00000254029.1, ENST00000254029.2, ENST00000254029.3, ENST00000254029.4, ENST00000254029.5, ENST00000254029.6, ENST00000254029.7, F8W913, NM_019045, Q0JS52, Q0JTF3, Q5JSH2, Q5JSH3, Q6ZSC1, Q7Z365, Q7Z3P6, Q8NAU8, Q8NHU5, Q9NUV4, RPH11, uc317fmw.1, uc317fmw.2, WDR44 , WDR44_HUMAN
UCSC ID: ENST00000254029.8_5
RefSeq Accession: NM_019045.5
Protein: Q5JSH3 (aka WDR44_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.