Human Gene WDR26 (ENST00000414423.9_10) from GENCODE V47lift37

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Description: WD repeat domain 26, transcript variant 3 (from RefSeq NM_001379403.1)
Gencode Transcript: ENST00000414423.9_10
Gencode Gene: ENSG00000162923.18_18
Transcript (Including UTRs)
Position: hg19 chr1:224,572,848-224,622,499 Size: 49,652 Total Exon Count: 14 Strand: -
Coding Region
Position: hg19 chr1:224,577,537-224,622,107 Size: 44,571 Coding Exon Count: 14

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:224,572,848-224,622,499)			mRNA (may differ from genome)		Protein (761 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: WDR26 Diseases sorted by gene-association score: skraban-deardorff syndrome* (900), klebsiella infection (17), chromosome 1q41-q42 deletion syndrome (10) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002994 Clofibrate C006253 pirinixic acid C495626 14-deoxy-11,12-didehydroandrographolide D000082 Acetaminophen D000638 Amiodarone D001151 Arsenic D001553 Benzbromarone D002794 Choline D003300 Copper D019327 Copper Sulfate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 29.57 RPKM in Skin - Sun Exposed (Lower leg) Total median expression: 861.84 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-168.60	392	-0.430	Picture	PostScript	Text
3' UTR	-1127.70	4689	-0.240	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Descriptions from all associated GenBank mRNAs


	AK023023 - Homo sapiens cDNA FLJ12961 fis, clone NT2RP2005645. AY221751 - Homo sapiens myocardial ischemic preconditioning upregulated protein 2 (MIP2) mRNA, complete cds. AB209887 - Homo sapiens mRNA for WD repeat domain 26 variant protein. BC041978 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:5303050). AK027236 - Homo sapiens cDNA: FLJ23583 fis, clone LNG13775. BC063817 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:6502986), partial cds. BC031471 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:3880754), partial cds. AY304473 - Homo sapiens WD40 repeat protein 26 (WDR26) mRNA, complete cds. JD385656 - Sequence 366680 from Patent EP1572962. JD344308 - Sequence 325332 from Patent EP1572962. JD171494 - Sequence 152518 from Patent EP1572962. JD309590 - Sequence 290614 from Patent EP1572962. JD391902 - Sequence 372926 from Patent EP1572962. JD243461 - Sequence 224485 from Patent EP1572962. JD273243 - Sequence 254267 from Patent EP1572962. JD427219 - Sequence 408243 from Patent EP1572962. JD331704 - Sequence 312728 from Patent EP1572962. JD248863 - Sequence 229887 from Patent EP1572962. JD565889 - Sequence 546913 from Patent EP1572962. JD284226 - Sequence 265250 from Patent EP1572962. JD299046 - Sequence 280070 from Patent EP1572962. JD303590 - Sequence 284614 from Patent EP1572962. JD052911 - Sequence 33935 from Patent EP1572962. JD363740 - Sequence 344764 from Patent EP1572962. JD502887 - Sequence 483911 from Patent EP1572962. EF011612 - Homo sapiens CDW2/WDR26 mRNA, complete cds. BC052301 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone MGC:59723 IMAGE:6420398), complete cds. BC034498 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:4831010), partial cds. AK024669 - Homo sapiens cDNA: FLJ21016 fis, clone CAE05735. AK225061 - Homo sapiens mRNA for WD repeat domain 26 variant, clone: CAE05735. AK299230 - Homo sapiens cDNA FLJ56418 complete cds, highly similar to WD repeat protein 26. JD538596 - Sequence 519620 from Patent EP1572962. JD484539 - Sequence 465563 from Patent EP1572962. JD314000 - Sequence 295024 from Patent EP1572962. AB385130 - Synthetic construct DNA, clone: pF1KB5596, Homo sapiens WDR26 gene for WD repeat protein 26, complete cds, without stop codon, in Flexi system. AK307909 - Homo sapiens cDNA, FLJ97857. AB586698 - Homo sapiens mRNA, IgA nephropathy-related cDNA 4. AF130049 - Homo sapiens clone FLB3411 PRO0852 mRNA, complete cds. JD458504 - Sequence 439528 from Patent EP1572962. JD458352 - Sequence 439376 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A499FIZ0, A0A499FIZ0_HUMAN, ENST00000414423.1, ENST00000414423.2, ENST00000414423.3, ENST00000414423.4, ENST00000414423.5, ENST00000414423.6, ENST00000414423.7, ENST00000414423.8, NM_001379403, uc319khi.1, uc319khi.2, WDR26 UCSC ID: ENST00000414423.9_10 RefSeq Accession: NM_001379403.1

GeneReviews for This Gene


	GeneReviews article(s) related to gene WDR26: wdr26-id (WDR26-Related Intellectual Disability)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.