Human Gene WBP2 (ENST00000254806.8_13) from GENCODE V47lift37

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Description: WW domain binding protein 2, transcript variant 1 (from RefSeq NM_012478.4)
Gencode Transcript: ENST00000254806.8_13
Gencode Gene: ENSG00000132471.12_18
Transcript (Including UTRs)
Position: hg19 chr17:73,841,780-73,851,416 Size: 9,637 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr17:73,842,815-73,851,378 Size: 8,564 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:73,841,780-73,851,416)			mRNA (may differ from genome)		Protein (261 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: WBP2_HUMAN DESCRIPTION: RecName: Full=WW domain-binding protein 2; Short=WBP-2; SUBUNIT: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4 (By similarity). INTERACTION: Q9GZV5:WWTR1; NbExp=6; IntAct=EBI-727055, EBI-747743; TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The WW-binding 1 motif mediates interaction with NEDD4 (By similarity). SIMILARITY: Contains 1 GRAM domain. SEQUENCE CAUTION: Sequence=AAD10951.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: WBP2 Diseases sorted by gene-association score: deafness, autosomal recessive 107* (900) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C006780 bisphenol A C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D000643 Ammonium Chloride D001241 Aspirin D016572 Cyclosporine D004041 Dietary Fats D004997 Ethinyl Estradiol D018817 N-Methyl-3,4-methylenedioxyamphetamine D012643 Selenium more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 184.79 RPKM in Brain - Cortex Total median expression: 4283.29 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.30	38	-0.218	Picture	PostScript	Text
3' UTR	-373.80	1035	-0.361	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004182 - GRAM
IPR018826 - WW-domain-binding

Pfam Domains:
PF02893 - GRAM domain

SCOP Domains:
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q969T9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001105 RNA polymerase II transcription coactivator activity GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0030331 estrogen receptor binding GO:0031490 chromatin DNA binding Biological Process: GO:0006366 transcription from RNA polymerase II promoter GO:0032570 response to progesterone GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway GO:0043627 response to estrogen GO:0045184 establishment of protein localization GO:0045815 positive regulation of gene expression, epigenetic GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050847 progesterone receptor signaling pathway GO:0071391 cellular response to estrogen stimulus GO:0071442 positive regulation of histone H3-K14 acetylation Cellular Component: GO:0000790 nuclear chromatin GO:0005634 nucleus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AL049981 - Homo sapiens mRNA; cDNA DKFZp564D012 (from clone DKFZp564D012). BC010616 - Homo sapiens WW domain binding protein 2, mRNA (cDNA clone MGC:18269 IMAGE:4177319), complete cds. AK094458 - Homo sapiens cDNA FLJ37139 fis, clone BRACE2023727. BC007452 - Homo sapiens WW domain binding protein 2, mRNA (cDNA clone MGC:4586 IMAGE:3140484), complete cds. AK057881 - Homo sapiens cDNA FLJ25152 fis, clone CBR07790, highly similar to Human WW domain binding protein-2 mRNA. AK128407 - Homo sapiens cDNA FLJ46550 fis, clone THYMU3038603. JD562416 - Sequence 543440 from Patent EP1572962. JD551158 - Sequence 532182 from Patent EP1572962. U79458 - Human WW domain binding protein-2 mRNA, complete cds. JD395335 - Sequence 376359 from Patent EP1572962. JD258630 - Sequence 239654 from Patent EP1572962. JD556052 - Sequence 537076 from Patent EP1572962. JD537712 - Sequence 518736 from Patent EP1572962. JD069121 - Sequence 50145 from Patent EP1572962. JD487324 - Sequence 468348 from Patent EP1572962. JD116067 - Sequence 97091 from Patent EP1572962. JD535387 - Sequence 516411 from Patent EP1572962. JD519534 - Sequence 500558 from Patent EP1572962. JD413027 - Sequence 394051 from Patent EP1572962. JD392699 - Sequence 373723 from Patent EP1572962. JD223618 - Sequence 204642 from Patent EP1572962. DQ570783 - Homo sapiens piRNA piR-30895, complete sequence. AK293214 - Homo sapiens cDNA FLJ59459 complete cds, highly similar to WW domain-binding protein 2. JD459987 - Sequence 441011 from Patent EP1572962. JD158516 - Sequence 139540 from Patent EP1572962. AK294155 - Homo sapiens cDNA FLJ59865 complete cds, highly similar to WW domain-binding protein 2. JD416556 - Sequence 397580 from Patent EP1572962. JD174306 - Sequence 155330 from Patent EP1572962. AF087866 - Homo sapiens WW-domain binding protein 2 mRNA, complete cds. AK294082 - Homo sapiens cDNA FLJ57063 complete cds, highly similar to WW domain-binding protein 2. JD294549 - Sequence 275573 from Patent EP1572962. JD485240 - Sequence 466264 from Patent EP1572962. JD376475 - Sequence 357499 from Patent EP1572962. JD115978 - Sequence 97002 from Patent EP1572962. DQ891052 - Synthetic construct clone IMAGE:100003682; FLH168862.01X; RZPDo839D1294D WW domain binding protein 2 (WBP2) gene, encodes complete protein. KJ898510 - Synthetic construct Homo sapiens clone ccsbBroadEn_07904 WBP2 gene, encodes complete protein. DQ894231 - Synthetic construct Homo sapiens clone IMAGE:100008691; FLH168858.01L; RZPDo839D1293D WW domain binding protein 2 (WBP2) gene, encodes complete protein. AB464357 - Synthetic construct DNA, clone: pF1KB9016, Homo sapiens WBP2 gene for WW domain binding protein 2, without stop codon, in Flexi system. AK300875 - Homo sapiens cDNA FLJ59995 complete cds, highly similar to WW domain-binding protein 2. CU679759 - Synthetic construct Homo sapiens gateway clone IMAGE:100018656 5' read WBP2 mRNA. DL492332 - Novel nucleic acids. DL490821 - Novel nucleic acids.

Other Names for This Gene


	Alternate Gene Symbols: B4DFG2, ENST00000254806.1, ENST00000254806.2, ENST00000254806.3, ENST00000254806.4, ENST00000254806.5, ENST00000254806.6, ENST00000254806.7, NM_012478, O95638, Q969T9, uc317fpq.1, uc317fpq.2, WBP2_HUMAN UCSC ID: ENST00000254806.8_13 RefSeq Accession: NM_012478.4 Protein: Q969T9 (aka WBP2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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