ID:WBP11_HUMAN DESCRIPTION: RecName: Full=WW domain-binding protein 11; Short=WBP-11; AltName: Full=Npw38-binding protein; Short=NpwBP; AltName: Full=SH3 domain-binding protein SNP70; AltName: Full=Splicing factor that interacts with PQBP-1 and PP1; FUNCTION: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. SUBUNIT: Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts via the PGR motif with PQBP1 in the nucleus. Interacts with the WW domains of WBP4. INTERACTION: Q15365:PCBP1; NbExp=2; IntAct=EBI-714455, EBI-946095; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Co-localized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09429 - WW domain binding protein 11
ModBase Predicted Comparative 3D Structure on Q9Y2W2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC016441 - Homo sapiens WW domain binding protein 11, mRNA (cDNA clone IMAGE:3448162), partial cds. BC013095 - Homo sapiens WW domain binding protein 11, mRNA (cDNA clone IMAGE:3863933), **** WARNING: chimeric clone ****. BC023532 - Homo sapiens WW domain binding protein 11, mRNA (cDNA clone MGC:14187 IMAGE:4122697), complete cds. BC001621 - Homo sapiens WW domain binding protein 11, mRNA (cDNA clone MGC:1166 IMAGE:3357963), complete cds. AB029309 - Homo sapiens mRNA for Npw38-binding protein NpwBP, complete cds. AK302244 - Homo sapiens cDNA FLJ60194 complete cds, highly similar to WW domain-binding protein 11. AK297410 - Homo sapiens cDNA FLJ58174 complete cds, highly similar to WW domain-binding protein 11. AF118023 - Homo sapiens SH3 domain-binding protein SNP70 mRNA, complete cds. DQ892540 - Synthetic construct clone IMAGE:100005170; FLH187305.01X; RZPDo839F1172D WW domain binding protein 11 (WBP11) gene, encodes complete protein. DQ895751 - Synthetic construct Homo sapiens clone IMAGE:100010211; FLH187301.01L; RZPDo839F1162D WW domain binding protein 11 (WBP11) gene, encodes complete protein. KJ893981 - Synthetic construct Homo sapiens clone ccsbBroadEn_03375 WBP11 gene, encodes complete protein. AB384898 - Synthetic construct DNA, clone: pF1KB4107, Homo sapiens WBP11 gene for WW domain-binding protein 11, complete cds, without stop codon, in Flexi system. JD081089 - Sequence 62113 from Patent EP1572962. JD553743 - Sequence 534767 from Patent EP1572962. DQ571703 - Homo sapiens piRNA piR-31815, complete sequence. JD485429 - Sequence 466453 from Patent EP1572962. JD408966 - Sequence 389990 from Patent EP1572962. JD235786 - Sequence 216810 from Patent EP1572962. JD246324 - Sequence 227348 from Patent EP1572962. JD165115 - Sequence 146139 from Patent EP1572962. JD038070 - Sequence 19094 from Patent EP1572962. JD263519 - Sequence 244543 from Patent EP1572962. DQ597814 - Homo sapiens piRNA piR-35880, complete sequence. BX647347 - Homo sapiens mRNA; cDNA DKFZp779M1063 (from clone DKFZp779M1063). CU674790 - Synthetic construct Homo sapiens gateway clone IMAGE:100017752 5' read WBP11 mRNA. LF207444 - JP 2014500723-A/14947: Polycomb-Associated Non-Coding RNAs. LF366251 - JP 2014500723-A/173754: Polycomb-Associated Non-Coding RNAs. JD333110 - Sequence 314134 from Patent EP1572962. MA601828 - JP 2018138019-A/173754: Polycomb-Associated Non-Coding RNAs. MA443021 - JP 2018138019-A/14947: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y2W2 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
