ID:VEGFC_HUMAN DESCRIPTION: RecName: Full=Vascular endothelial growth factor C; Short=VEGF-C; AltName: Full=Flt4 ligand; Short=Flt4-L; AltName: Full=Vascular endothelial growth factor-related protein; Short=VRP; Flags: Precursor; FUNCTION: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. SUBUNIT: Homodimer; non-covalent and antiparallel. INTERACTION: P35916:FLT4; NbExp=2; IntAct=EBI-3405539, EBI-1005467; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. PTM: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49767
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ897733 - Synthetic construct Homo sapiens clone ccsbBroadEn_07127 VEGFC gene, encodes complete protein. LQ270820 - Sequence 148 from Patent WO2016071350. BC035212 - Homo sapiens vascular endothelial growth factor C, mRNA (cDNA clone MGC:24887 IMAGE:4753457), complete cds. X94216 - H.sapiens mRNA for VEGF-C protein. FW406920 - NUCLEIC ACID COMPOUNDS FOR INHIBITING VEGF FAMILY GENE EXPRESSION AND USES THEREOF. JA810033 - Sequence 1166 from Patent EP2468864. BC063685 - Homo sapiens vascular endothelial growth factor C, mRNA (cDNA clone MGC:74703 IMAGE:4513934), complete cds. U43142 - Human vascular endothelial growth factor related protein VRP mRNA, complete cds. U58111 - Human FLT4 ligand mRNA, complete cds. JD442088 - Sequence 423112 from Patent EP1572962. JD331253 - Sequence 312277 from Patent EP1572962. CR541897 - Homo sapiens full open reading frame cDNA clone RZPDo834C1033D for gene VEGFC, vascular endothelial growth factor C; complete cds, incl. stopcodon. AB590333 - Synthetic construct DNA, clone: pFN21AE1426, Homo sapiens VEGFC gene for vascular endothelial growth factor C, without stop codon, in Flexi system. DQ891162 - Synthetic construct clone IMAGE:100003792; FLH170840.01X; RZPDo839C03100D vascular endothelial growth factor C (VEGFC) gene, encodes complete protein. DQ893345 - Synthetic construct clone IMAGE:100005975; FLH196459.01X; RZPDo839D07156D vascular endothelial growth factor C (VEGFC) gene, encodes complete protein. DQ894481 - Synthetic construct Homo sapiens clone IMAGE:100008941; FLH170836.01L; RZPDo839C0399D vascular endothelial growth factor C (VEGFC) gene, encodes complete protein. DQ896666 - Synthetic construct Homo sapiens clone IMAGE:100011126; FLH196455.01L; RZPDo839D07155D vascular endothelial growth factor C (VEGFC) gene, encodes complete protein. AK313879 - Homo sapiens cDNA, FLJ94513, Homo sapiens vascular endothelial growth factor C (VEGFC), mRNA. JD395985 - Sequence 377009 from Patent EP1572962. JD471363 - Sequence 452387 from Patent EP1572962. JD191241 - Sequence 172265 from Patent EP1572962. JD128783 - Sequence 109807 from Patent EP1572962. JD547181 - Sequence 528205 from Patent EP1572962. JD056230 - Sequence 37254 from Patent EP1572962. JD406055 - Sequence 387079 from Patent EP1572962. JD271292 - Sequence 252316 from Patent EP1572962. JD458514 - Sequence 439538 from Patent EP1572962. JD057274 - Sequence 38298 from Patent EP1572962. JD406801 - Sequence 387825 from Patent EP1572962. JD461601 - Sequence 442625 from Patent EP1572962. JD056228 - Sequence 37252 from Patent EP1572962. JD458513 - Sequence 439537 from Patent EP1572962. JD458511 - Sequence 439535 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P49767 (Reactome details) participates in the following event(s):
R-HSA-195378 Homodimerization of VEGF proteins R-HSA-481007 Exocytosis of platelet alpha granule contents R-HSA-194308 VEGF-C,D bind to VEGFR3 leading to receptor dimerization R-HSA-194310 VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization R-HSA-194313 VEGF ligand-receptor interactions R-HSA-114608 Platelet degranulation R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization R-HSA-194138 Signaling by VEGF R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-162582 Signal Transduction R-HSA-109582 Hemostasis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
