Human Gene VCL (ENST00000211998.10_10) from GENCODE V47lift37
Description: vinculin, transcript variant 1 (from RefSeq NM_014000.3)Gencode Transcript: ENST00000211998.10_10Gencode Gene: ENSG00000035403.18_11Transcript (Including UTRs) Position: hg19 chr10:75,757,874-75,879,927 Size: 122,054 Total Exon Count: 22 Strand: +Coding Region Position: hg19 chr10:75,757,966-75,877,927 Size: 119,962 Coding Exon Count: 22
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: VCL
Diseases sorted by gene-association score: cardiomyopathy, dilated, 1w * (1229), cardiomyopathy, hypertrophic, 15 * (1200), vcl-related dilated cardiomyopathy * (500), vcl-related familial hypertrophic cardiomyopathy * (500), familial isolated dilated cardiomyopathy * (94), dilated cardiomyopathy * (33), shigellosis (19), larynx verrucous carcinoma (16), pelvic varices (15), becker muscular dystrophy (14), cardiomyopathy (14), congestive heart failure (12), darier disease (9), grover's disease (9), butterfly-shaped pigment dystrophy (9), cerebrotendinous xanthomatosis (8), childhood kidney cell carcinoma (8), cardiomyopathy, familial hypertrophic (7), quebec platelet disorder (7), acute cor pulmonale (6), acute pulmonary heart disease (5), epidermolysis bullosa simplex with muscular dystrophy (5), duchenne muscular dystrophy (3)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D001151
Arsenic
D001564
Benzo(a)pyrene
D016572
Cyclosporine
D003993
Dibutyl Phthalate
D011692
Puromycin Aminonucleoside
D014635
Valproic Acid
C006253
pirinixic acid
C028474
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C024709
2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone
C023514
2,6-dinitrotoluene
C017906
3-dinitrobenzene
C009505
4,4'-diaminodiphenylmethane
C012606
4-vinyl-1-cyclohexene dioxide
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
D000082
Acetaminophen
D000643
Ammonium Chloride
D000968
Antimycin A
D001149
Arsenates
D001241
Aspirin
D001280
Atrazine
D019256
Cadmium Chloride
D002737
Chloroprene
D002945
Cisplatin
D003300
Copper
D019327
Copper Sulfate
D004041
Dietary Fats
D004051
Diethylhexyl Phthalate
D004958
Estradiol
D000431
Ethanol
D005472
Fluorouracil
D019833
Genistein
D006861
Hydrogen Peroxide
D008274
Magnesium
D015741
Metribolone
D018817
N-Methyl-3,4-methylenedioxyamphetamine
D009532
Nickel
D015242
Ofloxacin
D010100
Oxygen
C100442
PD 150606
D010795
Phthalic Acids
C513635
S-2-pentyl-4-pentynoic hydroxamic acid
D019821
Simvastatin
D012906
Smoke
D012999
Soman
D013749
Tetrachlorodibenzodioxin
D014212
Tretinoin
D014640
Vancomycin
C023650
aniline
C044887
beta-methylcholine
C074702
chromium hexavalent ion
C018021
cobaltous chloride
C056933
fumonisin B1
C005219
methyl cellosolve
C063855
microcystin RR
C017096
n-butoxyethanol
C031721
naphthalene
C041786
palm oil
C059514
resveratrol
C089032
rimonabant
C009277
sodium arsenate
C016104
sodium bichromate
C017947
sodium arsenite
C096900
thrombin receptor-activating peptide SFLLRNPNDKY
C012589
trichostatin A
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BX537994 - Homo sapiens mRNA; cDNA DKFZp686C1586 (from clone DKFZp686C1586); complete cds.LF209953 - JP 2014500723-A/17456: Polycomb-Associated Non-Coding RNAs.AK304823 - Homo sapiens cDNA FLJ59659 complete cds, highly similar to Vinculin.EU794673 - Homo sapiens epididymis luminal protein 114 (HEL114) mRNA, complete cds.LF384967 - JP 2014500723-A/192470: Polycomb-Associated Non-Coding RNAs.AK300280 - Homo sapiens cDNA FLJ53006 complete cds, highly similar to Vinculin.AK296509 - Homo sapiens cDNA FLJ55698 complete cds, highly similar to Vinculin.BC099919 - Homo sapiens cDNA clone IMAGE:4549190, **** WARNING: chimeric clone ****.BC039174 - Homo sapiens vinculin, mRNA (cDNA clone MGC:21734 IMAGE:4520338), complete cds.GQ900900 - Homo sapiens clone HEL-T-12 epididymis secretory sperm binding protein mRNA, complete cds.M33308 - Human vinculin mRNA, complete cds.AB385172 - Synthetic construct DNA, clone: pF1KB7006, Homo sapiens VCL gene for vinculin, complete cds, without stop codon, in Flexi system.DQ894680 - Synthetic construct Homo sapiens clone IMAGE:100009140; FLH177426.01L; RZPDo839H11123D vinculin (VCL) gene, encodes complete protein.AK126978 - Homo sapiens cDNA FLJ45031 fis, clone BRAWH3018548, highly similar to Vinculin.MA620544 - JP 2018138019-A/192470: Polycomb-Associated Non-Coding RNAs.MA445530 - JP 2018138019-A/17456: Polycomb-Associated Non-Coding RNAs.LF333168 - JP 2014500723-A/140671: Polycomb-Associated Non-Coding RNAs.MA568745 - JP 2018138019-A/140671: Polycomb-Associated Non-Coding RNAs.LF333189 - JP 2014500723-A/140692: Polycomb-Associated Non-Coding RNAs.LF333190 - JP 2014500723-A/140693: Polycomb-Associated Non-Coding RNAs.LF333193 - JP 2014500723-A/140696: Polycomb-Associated Non-Coding RNAs.LF333196 - JP 2014500723-A/140699: Polycomb-Associated Non-Coding RNAs.LF333197 - JP 2014500723-A/140700: Polycomb-Associated Non-Coding RNAs.AL832130 - Homo sapiens mRNA; cDNA DKFZp686H1210 (from clone DKFZp686H1210).LF333200 - JP 2014500723-A/140703: Polycomb-Associated Non-Coding RNAs.LF333201 - JP 2014500723-A/140704: Polycomb-Associated Non-Coding RNAs.LF333205 - JP 2014500723-A/140708: Polycomb-Associated Non-Coding RNAs.LF333206 - JP 2014500723-A/140709: Polycomb-Associated Non-Coding RNAs.LF333207 - JP 2014500723-A/140710: Polycomb-Associated Non-Coding RNAs.LF333209 - JP 2014500723-A/140712: Polycomb-Associated Non-Coding RNAs.LF333211 - JP 2014500723-A/140714: Polycomb-Associated Non-Coding RNAs.LF333216 - JP 2014500723-A/140719: Polycomb-Associated Non-Coding RNAs.LF333218 - JP 2014500723-A/140721: Polycomb-Associated Non-Coding RNAs.BC013847 - Homo sapiens vinculin, mRNA (cDNA clone IMAGE:4387297).LF333220 - JP 2014500723-A/140723: Polycomb-Associated Non-Coding RNAs.LF333225 - JP 2014500723-A/140728: Polycomb-Associated Non-Coding RNAs.JD225094 - Sequence 206118 from Patent EP1572962.LF333228 - JP 2014500723-A/140731: Polycomb-Associated Non-Coding RNAs.JD052412 - Sequence 33436 from Patent EP1572962.LF333229 - JP 2014500723-A/140732: Polycomb-Associated Non-Coding RNAs.JD074663 - Sequence 55687 from Patent EP1572962.JD060804 - Sequence 41828 from Patent EP1572962.JD163750 - Sequence 144774 from Patent EP1572962.JD092473 - Sequence 73497 from Patent EP1572962.LF333232 - JP 2014500723-A/140735: Polycomb-Associated Non-Coding RNAs.JD400750 - Sequence 381774 from Patent EP1572962.JD158428 - Sequence 139452 from Patent EP1572962.JD235546 - Sequence 216570 from Patent EP1572962.LF333234 - JP 2014500723-A/140737: Polycomb-Associated Non-Coding RNAs.JD392496 - Sequence 373520 from Patent EP1572962.JD037343 - Sequence 18367 from Patent EP1572962.JD399716 - Sequence 380740 from Patent EP1572962.JD419297 - Sequence 400321 from Patent EP1572962.JD369072 - Sequence 350096 from Patent EP1572962.JD455606 - Sequence 436630 from Patent EP1572962.LF333236 - JP 2014500723-A/140739: Polycomb-Associated Non-Coding RNAs.JD497329 - Sequence 478353 from Patent EP1572962.JD392710 - Sequence 373734 from Patent EP1572962.JD189691 - Sequence 170715 from Patent EP1572962.JD185484 - Sequence 166508 from Patent EP1572962.JD488425 - Sequence 469449 from Patent EP1572962.JD533278 - Sequence 514302 from Patent EP1572962.JD301068 - Sequence 282092 from Patent EP1572962.JD284299 - Sequence 265323 from Patent EP1572962.JD411091 - Sequence 392115 from Patent EP1572962.JD506483 - Sequence 487507 from Patent EP1572962.LF333238 - JP 2014500723-A/140741: Polycomb-Associated Non-Coding RNAs.JD236695 - Sequence 217719 from Patent EP1572962.JD293813 - Sequence 274837 from Patent EP1572962.LF333240 - JP 2014500723-A/140743: Polycomb-Associated Non-Coding RNAs.DL491440 - Novel nucleic acids.DL490061 - Novel nucleic acids.LF333241 - JP 2014500723-A/140744: Polycomb-Associated Non-Coding RNAs.MA568766 - JP 2018138019-A/140692: Polycomb-Associated Non-Coding RNAs.MA568767 - JP 2018138019-A/140693: Polycomb-Associated Non-Coding RNAs.MA568770 - JP 2018138019-A/140696: Polycomb-Associated Non-Coding RNAs.MA568773 - JP 2018138019-A/140699: Polycomb-Associated Non-Coding RNAs.MA568774 - JP 2018138019-A/140700: Polycomb-Associated Non-Coding RNAs.MA568777 - JP 2018138019-A/140703: Polycomb-Associated Non-Coding RNAs.MA568778 - JP 2018138019-A/140704: Polycomb-Associated Non-Coding RNAs.MA568782 - JP 2018138019-A/140708: Polycomb-Associated Non-Coding RNAs.MA568783 - JP 2018138019-A/140709: Polycomb-Associated Non-Coding RNAs.MA568784 - JP 2018138019-A/140710: Polycomb-Associated Non-Coding RNAs.MA568786 - JP 2018138019-A/140712: Polycomb-Associated Non-Coding RNAs.MA568788 - JP 2018138019-A/140714: Polycomb-Associated Non-Coding RNAs.MA568793 - JP 2018138019-A/140719: Polycomb-Associated Non-Coding RNAs.MA568795 - JP 2018138019-A/140721: Polycomb-Associated Non-Coding RNAs.MA568797 - JP 2018138019-A/140723: Polycomb-Associated Non-Coding RNAs.MA568802 - JP 2018138019-A/140728: Polycomb-Associated Non-Coding RNAs.MA568805 - JP 2018138019-A/140731: Polycomb-Associated Non-Coding RNAs.MA568806 - JP 2018138019-A/140732: Polycomb-Associated Non-Coding RNAs.MA568809 - JP 2018138019-A/140735: Polycomb-Associated Non-Coding RNAs.MA568811 - JP 2018138019-A/140737: Polycomb-Associated Non-Coding RNAs.MA568813 - JP 2018138019-A/140739: Polycomb-Associated Non-Coding RNAs.MA568815 - JP 2018138019-A/140741: Polycomb-Associated Non-Coding RNAs.MA568817 - JP 2018138019-A/140743: Polycomb-Associated Non-Coding RNAs.MA568818 - JP 2018138019-A/140744: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000211998.1, ENST00000211998.2, ENST00000211998.3, ENST00000211998.4, ENST00000211998.5, ENST00000211998.6, ENST00000211998.7, ENST00000211998.8, ENST00000211998.9, hCG_2024635 , HEL114 , NM_014000, uc317clk.1, uc317clk.2, V9HWK2, V9HWK2_HUMAN, VCL UCSC ID: ENST00000211998.10_10RefSeq Accession: NM_014000.3
GeneReviews for This Gene
GeneReviews article(s) related to gene VCL:dcm-ov hyper-card
Gene Model Information
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 