ID:UVRAG_HUMAN DESCRIPTION: RecName: Full=UV radiation resistance-associated gene protein; AltName: Full=p63; SUBUNIT: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. SUBCELLULAR LOCATION: Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial. TISSUE SPECIFICITY: Highly expressed in brain, lung, kidney and liver. DISEASE: Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25). SIMILARITY: Contains 1 C2 domain. SEQUENCE CAUTION: Sequence=CAA67507.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2Y5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006914 autophagy GO:0006974 cellular response to DNA damage stimulus GO:0007051 spindle organization GO:0007059 chromosome segregation GO:0007098 centrosome cycle GO:0032465 regulation of cytokinesis GO:0032801 receptor catabolic process GO:0035493 SNARE complex assembly GO:0046718 viral entry into host cell GO:0051684 maintenance of Golgi location GO:0060627 regulation of vesicle-mediated transport GO:0071900 regulation of protein serine/threonine kinase activity GO:0071985 multivesicular body sorting pathway GO:0097680 double-strand break repair via classical nonhomologous end joining GO:1901098 positive regulation of autophagosome maturation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
