Human Gene UTS2B (ENST00000340524.10_6) from GENCODE V47lift37
  Description: urotensin 2B (from RefSeq NM_198152.5)
Gencode Transcript: ENST00000340524.10_6
Gencode Gene: ENSG00000188958.10_12
Transcript (Including UTRs)
   Position: hg19 chr3:190,984,957-191,048,315 Size: 63,359 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr3:190,986,205-190,999,978 Size: 13,774 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:190,984,957-191,048,315)mRNA (may differ from genome)Protein (119 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UTS2B_HUMAN
DESCRIPTION: RecName: Full=Urotensin-2B; AltName: Full=Urotensin II-related peptide; AltName: Full=Urotensin IIB; Short=U-IIB; Short=UIIB; AltName: Full=Urotensin-2 domain-containing protein; Flags: Precursor;
FUNCTION: Potent vasoconstrictor (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the urotensin-2 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.24 RPKM in Testis
Total median expression: 5.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -206.90777-0.266 Picture PostScript Text
3' UTR -309.401248-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001483 - Urotensin_II

ModBase Predicted Comparative 3D Structure on Q765I0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0010469 regulation of receptor activity
GO:0097746 regulation of blood vessel diameter

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AK090630 - Homo sapiens cDNA FLJ33311 fis, clone BNGH42005235, highly similar to Urotensin-2B precursor.
AX746546 - Sequence 71 from Patent EP1308459.
AY321313 - Homo sapiens urotensin IIB precursor, mRNA, complete cds.
AB116021 - Homo sapiens URP mRNA for urotensin II-related peptide, complete cds.
BC112166 - Homo sapiens urotensin 2 domain containing, mRNA (cDNA clone MGC:138371 IMAGE:8327634), complete cds.
JD530887 - Sequence 511911 from Patent EP1572962.
JD503097 - Sequence 484121 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q765I0 (Reactome details) participates in the following event(s):

R-HSA-445113 Urotensin-2 receptor binds urotensin-2 and 2B
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQY8, D3DNW1, ENST00000340524.1, ENST00000340524.2, ENST00000340524.3, ENST00000340524.4, ENST00000340524.5, ENST00000340524.6, ENST00000340524.7, ENST00000340524.8, ENST00000340524.9, NM_198152, Q2M1Z2, Q765I0, uc317vru.1, uc317vru.2, URP, UTS2B_HUMAN, UTS2D
UCSC ID: ENST00000340524.10_6
RefSeq Accession: NM_198152.5
Protein: Q765I0 (aka UTS2B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.